Reviewed, UniProtKB/Swiss-Prot Q9ZFL7 (UXUA_BACST)

Names and origin

Protein names

Recommended name:
    Mannonate dehydratase
    EC=4.2.1.8
Alternative name(s):
    D-mannonate hydrolase

Gene names

Name:

uxuA

Organism

Bacillus stearothermophilus (Geobacillus stearothermophilus)

Taxonomic identifier

1422 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Geobacillus

Protein attributes

Sequence length	371 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP MF_00106
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00106
Sequence similarities	Belongs to the mannonate dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	mannonate dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 371	371	Mannonate dehydratase HAMAP MF_00106		PRO_0000170663

Sequences

	Sequence		Length	Mass (Da)
	Q9ZFL7-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: DF82D85FACDAE944	FASTA	371	42,532
	10 20 30 40 50 60 MKMTFRWFGK EHDTVSLDHI RQIPGVEGIV GALYHIPVGE VWPLDDILEL KRQVNEKGFH 70 80 90 100 110 120 LEVIESVNVH EDIKLGLPSR DRYIENYKQT IRNLAKAGVK VICYNFMPIF DWTRSDLAKR 130 140 150 160 170 180 RPDGSTVLAY EKQKIEQIDP EEMIRRIESG ANGFLLPGWE PERLKTIKPL FSLYKGVTEE 190 200 210 220 230 240 DLFDHLRYFL EQIVPVAEEC GVRMALHPDD PPWSVFGLPR IATNKENLDR IVHMVNSPAN 250 260 270 280 290 300 GLTLCSGSLG ANPANDVPDI FRHFLRMGRV PFAHVRNVEI HANGDFEETS HRSCDGSLNI 310 320 330 340 350 360 CEIMKALHEA NFQGYIRPDH GRMIWGEQAR PGYGLYDRAL GIMYLLGIWD SLENEKKKQE 370 GEKTCSRSIQ V

References

[1]	"The glucuronic acid utilization gene cluster from Bacillus stearothermophilus T-6." Shulami S., Gat O., Sonenshein A.L., Shoham Y. J. Bacteriol. 181:3695-3704(1999) [PubMed: 10368143] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: T-6.

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ868502 Genomic DNA. Translation: ABI49946.1.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	4.2.1.8. 266715.
Family and domain databases
HAMAP	MF_00106. [Tree]
InterPro	IPR004628. Man_deHydtase. IPR013022. Xyl_isomerase-like_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
Pfam	PF03786. UxuA. 1 hit. [Graphical view]
PIRSF	PIRSF016049. Man_dehyd. 1 hit.
TIGRFAMs	TIGR00695. uxuA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UXUA_BACST

Accession

Primary (citable) accession number: Q9ZFL7
Secondary accession number(s): Q09LX9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	January 20, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)