Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutamate--tRNA ligase 1

Gene

gltX1

Organism
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei246ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 1UniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetase 1UniRule annotation
Short name:
GluRS 1UniRule annotation
Gene namesi
Name:gltX1UniRule annotation
Synonyms:gluS
Ordered Locus Names:RHOS4_05770
ORF Names:RSP_1995
OrganismiRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Taxonomic identifieri272943 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001196371 – 471Glutamate--tRNA ligase 1Add BLAST471

Proteomic databases

PRIDEiQ9ZFA3

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi272943.RSP_1995

Structurei

3D structure databases

ProteinModelPortaliQ9ZFA3
SMRiQ9ZFA3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi15 – 25"HIGH" regionUniRule annotationAdd BLAST11
Motifi243 – 247"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252722
KOiK01885
OMAiHYINTLP
OrthoDBiPOG091H021W
PhylomeDBiQ9ZFA3

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ZFA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAASDKPVV TRFAPSPTGY LHIGGGRTAL FNWLYARGRK GTFLLRIEDT
60 70 80 90 100
DRERSTPEAT DAILRGLTWL GLDWDGEVVS QFARKDRHAE VAREMLERGA
110 120 130 140 150
AYKCFSTQEE IEAFRESARA EGRSTLFRSP WRDADPTSHP DAPFVIRMKA
160 170 180 190 200
PRSGETVIED EVQGTVRFQN ETLDDMVVLR SDGTPTYMLA VVVDDHDMGV
210 220 230 240 250
THVIRGDDHL NNAARQTMVY EAMGWEVPVW AHIPLIHGPD GKKLSKRHGA
260 270 280 290 300
LGVEEYQAMG YPAAGMRNYL ARLGWSHGDD EFFTSEQAMD WFDLGGIGRS
310 320 330 340 350
PARLDFKKLE SVCGQHIAVM EDAELMREIA AYLAAARKPA LTDLQAARLE
360 370 380 390 400
KGLYALKDRA KTFPELLEKA RFALESRPIV ADDAAAKALD PVSRGILREL
410 420 430 440 450
TPMLQAASWS KQDLEAILTA FASEKGMGFG KLAAPLRTAL AGRTVTPSVY
460 470
DMMLVIGRDE TIARLEDAAA A
Length:471
Mass (Da):52,136
Last modified:May 1, 1999 - v1
Checksum:i044E8C102AB5FCB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF108766 Genomic DNA Translation: AAD09123.1
CP000143 Genomic DNA Translation: ABA78145.1
PIRiT46860
RefSeqiWP_011337143.1, NZ_AKVW01000001.1
YP_352046.1, NC_007493.2

Genome annotation databases

EnsemblBacteriaiABA78145; ABA78145; RSP_1995
GeneIDi3719328
KEGGirsp:RSP_1995
PATRICifig|272943.9.peg.884

Entry informationi

Entry nameiSYE1_RHOS4
AccessioniPrimary (citable) accession number: Q9ZFA3
Secondary accession number(s): Q3J4Y9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health