Q9ZEU7 (ECTB_CHRSD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Diaminobutyrate--2-oxoglutarate transaminase
EC=2.6.1.76

Alternative name(s):
DABA aminotransferase
Diaminobutyrate--2-oxoglutarate aminotransferase
L-2,4-diaminobutyric acid transaminase

Gene names

Name:	ectB
Ordered Locus Names:	Csal_1877

Organism

Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768) [Complete proteome] [HAMAP]

Taxonomic identifier

290398 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Halomonadaceae › Chromohalobacter › Chromohalobacter salexigens

Protein attributes

Sequence length	423 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes reversively the conversion of L-aspartate beta-semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate By similarity.
Catalytic activity	L-2,4-diaminobutanoate + 2-oxoglutarate = L-aspartate 4-semialdehyde + L-glutamate.
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amine and polyamine biosynthesis; ectoine biosynthesis; L-ectoine from L-aspartate 4-semialdehyde: step 1/3.
Subunit structure	Homohexamer By similarity.
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	ectoine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	diaminobutyrate-2-oxoglutarate transaminase activity Inferred from electronic annotation. Source: EC diaminobutyrate-pyruvate transaminase activity Inferred from electronic annotation. Source: InterPro pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 423	423	Diaminobutyrate--2-oxoglutarate transaminase		PRO_0000120522
Amino acid modifications
	Modified residue	267	1	N6-(pyridoxal phosphate)lysine Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9ZEU7 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 735C6BCF5A88288C	FASTA	423	46,200
	10 20 30 40 50 60 MQTQILERME SEVRTYSRSF PTVFTEAKGA RLHAEDGNQY IDFLAGAGTL NYGHNHPKLK 70 80 90 100 110 120 QALADYIASD GIVHGLDMWS AAKRDYLETL EEVILKPRGL DYKVHLPGPT GTNAVEAAIR 130 140 150 160 170 180 LARNAKGRHN IVTFTNGFHG VTMGALATTG NRKFREATGG IPTQGASFMP FDGYMGEGVD 190 200 210 220 230 240 TLSYFEKLLG DNSGGLDVPA AVIIETVQGE GGINPAGIPW LQRLEKICRD HDMLLIVDDI 250 260 270 280 290 300 QAGCGRTGKF FSFEHAGITP DIVTNSKSLS GFGLPFAHVL MRPELDIWKP GQYNGTFRGF 310 320 330 340 350 360 NLAFVTAAAA MRHFWSDDTF ERDVQRKGRV VEDRFQKLAS FMTEKGHPAS ERGRGLMRGL 370 380 390 400 410 420 DVGDGDMADK ITAQAFKNGL IIETSGHSGQ VIKCLCPLTI TDEDLVGGLD ILEQSVKEVF GQA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the genes for the biosynthesis of the compatible solute ectoine in the moderately halophilic bacterium Halomonas elongata DSM 3043." Canovas D., Vargas C., Calderon M.I., Ventosa A., Nieto J.J. Syst. Appl. Microbiol. 21:487-497(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete sequence of Chromohalobacter salexigens DSM 3043." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Saunders E., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Csonka L.N., O'Conner K., Vreeland R.H., Oren A., Vargas C., Nieto J., Arahal D.R., Goodner B., Wheeler C., Hall P., Ewing A., Benson L., McBeath D., Canovas D., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 3043 / ATCC BAA-138 / NCIMB 13768.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ011103 Genomic DNA. Translation: CAA09484.1. CP000285 Genomic DNA. Translation: ABE59229.1.
RefSeq	YP_573928.1. NC_007963.1.
3D structure databases
ProteinModelPortal	Q9ZEU7.
ModBase	Search...
Protein-protein interaction databases
STRING	290398.Csal_1877.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABE59229; ABE59229; Csal_1877.
GeneID	4028240.
KEGG	csa:Csal_1877.
PATRIC	21447566. VBIChrSal113723_1889.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0160.
HOGENOM	HOG000020206.
KO	K00836.
OMA	YSRGWPV.
ProtClustDB	PRK09264.
Enzyme and pathway databases
BioCyc	MetaCyc:MONOMER-801.
UniPathway	UPA00067; UER00121.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 2 hits.
InterPro	IPR005814. Aminotrans_3. IPR004637. Dat. IPR012773. Ectoine_EctB. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
PANTHER	PTHR11986. PTHR11986. 1 hit. PTHR11986:SF7. PTHR11986:SF7. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR00709. dat. 1 hit. TIGR02407. ectoine_ectB. 1 hit.
PROSITE	PS00600. AA_TRANSFER_CLASS_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ECTB_CHRSD

Accession

Primary (citable) accession number: Q9ZEU7
Secondary accession number(s): Q1QWC9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program