Reviewed, UniProtKB/Swiss-Prot Q9ZES2 (TRPE_BUCTC)

Names and origin

Protein names

Recommended name:
    Anthranilate synthase component 1
    EC=4.1.3.27
Alternative name(s):
    Anthranilate synthase component I

Gene names

Name:

trpE

Encoded on

Plasmid pBTc2

Organism

Buchnera aphidicola subsp. Tetraneura caerulescens

Taxonomic identifier

118111 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	526 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Technical term	Plasmid
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 526	526	Anthranilate synthase component 1		PRO_0000154088

Sequences

	Sequence		Length	Mass (Da)
	Q9ZES2-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 9A924CA0AC96471D	FASTA	526	60,469
	10 20 30 40 50 60 MYYRSIKSEI IQTICTYHEE PSLIFNKICR TKTETLLLES ATVHGKKNIE SMLIIDTAIK 70 80 90 100 110 120 ISCFKNIVEI EAISNNGLFL LNTIDLKILK KKSTKIKKKK SNVLEIHFPI FNYFTDEDKK 130 140 150 160 170 180 LFLTSVFDAL RIIKKSIKNP EKSKMGVFFG GILSYDLISS FEPIPRVFNS KYNHPDFCFY 190 200 210 220 230 240 LSENLLIFDH KKKKCKLQTN IFTDNEEEKL NILKRIKIIY NQIKEINSKK KNNRINTFND 250 260 270 280 290 300 FKTKNKKWVD CKNDSKVYKN KVKKMKQMIL NGEVFQIVIS RKFFLPCPYP LESYIFLKKN 310 320 330 340 350 360 NPSPYMFFMQ DRHFVLFGAS PESSLKFSSI TRKIEIHPIA GTRPRAFSSI KKIDINEDNK 370 380 390 400 410 420 MELAMRINSK ELAEHCMLVD LARNDLSRIC LPGSRVVSDL MKVVKYSHVM HLVSKVEGVL 430 440 450 460 470 480 RNDLDIFHAY QCCMNMGTLT GAPKIRAMQI IAEEGEIREC YGGAIGYFTG KGDLDTCIVI 490 500 510 520 RSAYVRNGIA CVQAGAGIVL DSIADEENEE CKNKAMAVIN AINKTL

References

[1]	"Plasmid-encoded anthranilate synthase (TrpEG) in Buchnera aphidicola from aphids of the family pemphigidae." van Ham R.C.H.J., Martinez-Torres D., Moya A., Latorre A. Appl. Environ. Microbiol. 65:117-125(1999) [PubMed: 9872768] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ012333 Genomic DNA. Translation: CAA09993.1.
3D structure databases
SMR	Q9ZES2. Positions 9-523.
ModBase	Search...
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR006805. Anth_synth_I_N. IPR019999. Anthranilate_synth_I_C. IPR015890. Chorismate-bd_C. IPR005257. TrpE_synth. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
PANTHER	PTHR11236. TRPE_1_chor_bd. 1 hit.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
TIGRFAMs	TIGR00565. trpE_proteo. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE_BUCTC

Accession

Primary (citable) accession number: Q9ZES2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	February 9, 2010
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)