Reviewed, UniProtKB/Swiss-Prot Q9ZER9 (TRPE_BUCPS)

Names and origin

Protein names

Recommended name:
    Anthranilate synthase component 1
    EC=4.1.3.27
Alternative name(s):
    Anthranilate synthase component I

Gene names

Name:

trpE

Encoded on

Plasmid pBPs2

Organism

Buchnera aphidicola subsp. Pemphigus spyrothecae

Taxonomic identifier

98799 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	520 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Technical term	Plasmid
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 520	520	Anthranilate synthase component 1		PRO_0000154084

Sequences

	Sequence		Length	Mass (Da)
	Q9ZER9-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 8637ABA7947D6135	FASTA	520	59,502
	10 20 30 40 50 60 MKNRRYEVEI LQIEGIYQSD PTTIFNQLCN KKKCTLLLES AEIDKKHALE SMIIIDSALR 70 80 90 100 110 120 ISSLDNIVTI EALTENGKSL LFKLDLLLPL TVKNVLFENS RRLIFPFINH EIDEDKKLRS 130 140 150 160 170 180 VSIFDTFRLL IKTMKIPKNL TKSMFFGGLF SYDLVNNFEK LPILNRNQKC PDLCFYLAET 190 200 210 220 230 240 LLILDHKKKN CIIQSSLFNR KSSEKNRLKK NLQEIKTKLT QNVPKIEHRK IDQISLKCNL 250 260 270 280 290 300 TDKEYIKIIK KMKQSIKKGD IFQVVPSRKF YLPCISSLSA YQRLKQSNPS PYMFFMQDSD 310 320 330 340 350 360 FTLFGASPES SLKYDSKSKK IEIYPIAGTR PRGKTENGLI DLDLDSKIEL EMRMNEKELS 370 380 390 400 410 420 EHLMLVDLAR NDLARICEPG SRYVASLTKV DRYSCVMHLV SKIVGRLKSN LDIFHAYCAC 430 440 450 460 470 480 MNMGTLTGAP KIKAMELISK FEKERRGSYG GSIGYFTESN NFDTCIIIRS AYVENNLATV 490 500 510 520 QAGAGIVLDS VPQEEANESR NKAQAVIQAI IYAHSSREVV

References

[1]	"Plasmid-encoded anthranilate synthase (TrpEG) in Buchnera aphidicola from aphids of the family pemphigidae." van Ham R.C.H.J., Martinez-Torres D., Moya A., Latorre A. Appl. Environ. Microbiol. 65:117-125(1999) [PubMed: 9872768] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ012334 Genomic DNA. Translation: CAA09996.1.
3D structure databases
HSSP	HSSP built from PDB template 1I1Q based on UniProtKB P00898.
ModBase	Search...
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR006805. Anth_synth_I_N. IPR019999. Anthranilate_synth_I_C. IPR015890. Chorismate-bd_C. IPR005257. TrpE_synth. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
PANTHER	PTHR11236. TRPE_1_chor_bd. 1 hit.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
ProDom	PD000779. Anth_synth_chor. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00565. trpE_proteo. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE_BUCPS

Accession

Primary (citable) accession number: Q9ZER9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	June 16, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)