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Protein

Peptide methionine sulfoxide reductase MsrA

Gene

msrA

Organism
Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).By similarity

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.
L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei53By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrA (EC:1.8.4.11)
Short name:
Protein-methionine-S-oxide reductase
Alternative name(s):
Peptide-methionine (S)-S-oxide reductase
Short name:
Peptide Met(O) reductase
Gene namesi
Name:msrA
Ordered Locus Names:Dda3937_00164
OrganismiDickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Taxonomic identifieri198628 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesPectobacteriaceaeDickeya
Proteomesi
  • UP000006859 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001385491 – 213Peptide methionine sulfoxide reductase MsrAAdd BLAST213

Interactioni

Protein-protein interaction databases

STRINGi198628.Dda3937_00164.

Structurei

3D structure databases

ProteinModelPortaliQ9ZEQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108HW8. Bacteria.
COG0225. LUCA.
HOGENOMiHOG000263862.
KOiK07304.
OMAiMVLRSEI.
OrthoDBiPOG091H059H.

Family and domain databases

Gene3Di3.30.1060.10. 1 hit.
HAMAPiMF_01401. MsrA. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMiSSF55068. SSF55068. 1 hit.
TIGRFAMsiTIGR00401. msrA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZEQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIANFDKTQP IGQSDALPGR TTPMPVARLH VVNQHSMTHV PDHMEVAIFA
60 70 80 90 100
MGCFWGVERL FWQQPGVYST ASGYCGGYTP NPTYREVCTG KTGHAEAVRV
110 120 130 140 150
VFDPAVVSYP QLLQLFWENH NPAQGMRQGN DIGTQYRSAI YTLTTEQETA
160 170 180 190 200
AKESYQRFQQ AMRDAGNDHD ITTEIQPAGP FYYAEDEHQQ YLHKNPDGYC
210
GLGGIGVCLP PQG
Length:213
Mass (Da):23,701
Last modified:May 1, 1999 - v1
Checksum:i9EE0F02FE7428CB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ012716 Genomic DNA. Translation: CAA10143.1.
CP002038 Genomic DNA. Translation: ADM99860.1.
RefSeqiWP_013319285.1. NC_014500.1.

Genome annotation databases

EnsemblBacteriaiADM99860; ADM99860; Dda3937_00164.
GeneIDi9735138.
KEGGiddd:Dda3937_00164.
PATRICi42319639. VBIDicDad25310_3608.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ012716 Genomic DNA. Translation: CAA10143.1.
CP002038 Genomic DNA. Translation: ADM99860.1.
RefSeqiWP_013319285.1. NC_014500.1.

3D structure databases

ProteinModelPortaliQ9ZEQ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198628.Dda3937_00164.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADM99860; ADM99860; Dda3937_00164.
GeneIDi9735138.
KEGGiddd:Dda3937_00164.
PATRICi42319639. VBIDicDad25310_3608.

Phylogenomic databases

eggNOGiENOG4108HW8. Bacteria.
COG0225. LUCA.
HOGENOMiHOG000263862.
KOiK07304.
OMAiMVLRSEI.
OrthoDBiPOG091H059H.

Family and domain databases

Gene3Di3.30.1060.10. 1 hit.
HAMAPiMF_01401. MsrA. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMiSSF55068. SSF55068. 1 hit.
TIGRFAMsiTIGR00401. msrA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMSRA_DICD3
AccessioniPrimary (citable) accession number: Q9ZEQ8
Secondary accession number(s): E0SEC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.