Q9ZEQ8 (MSRA_DICD3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA
Short name=Protein-methionine-S-oxide reductase
EC=1.8.4.11

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase
Short name=Peptide Met(O) reductase

Gene names

Name:	msrA
Ordered Locus Names:	Dda3937_00164

Organism

Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937)) [Complete proteome] [HAMAP]

Taxonomic identifier

198628 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Dickeya

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 213	213	Peptide methionine sulfoxide reductase MsrA HAMAP MF_01401		PRO_0000138549
Sites
	Active site	53	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ZEQ8 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 9EE0F02FE7428CB2	FASTA	213	23,701
	10 20 30 40 50 60 MIANFDKTQP IGQSDALPGR TTPMPVARLH VVNQHSMTHV PDHMEVAIFA MGCFWGVERL 70 80 90 100 110 120 FWQQPGVYST ASGYCGGYTP NPTYREVCTG KTGHAEAVRV VFDPAVVSYP QLLQLFWENH 130 140 150 160 170 180 NPAQGMRQGN DIGTQYRSAI YTLTTEQETA AKESYQRFQQ AMRDAGNDHD ITTEIQPAGP 190 200 210 FYYAEDEHQQ YLHKNPDGYC GLGGIGVCLP PQG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The minimal gene set member msrA, encoding peptide methionine sulfoxide reductase, is a virulence determinant of the plant pathogen Erwinia chrysanthemi." Hassouni M.E., Chambost J.P., Expert D., Van Gijsegem F., Barras F. Proc. Natl. Acad. Sci. U.S.A. 96:887-892(1999) [PubMed: 9927663] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 3937.
[2]	"Complete genome sequence of Dickeya dadantii 3937." International Erwinia Consortium Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 3937.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ012716 Genomic DNA. Translation: CAA10143.1. CP002038 Genomic DNA. Translation: ADM99860.1.
RefSeq	YP_003884417.1. NC_014500.1.
3D structure databases
ProteinModelPortal	Q9ZEQ8.
SMR	Q9ZEQ8. Positions 5-213.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9735138.
GenomeReviews	Gene locus Dda3937_00164 in contig CP002038_GR.
KEGG	ddd:Dda3937_00164.
PATRIC	42319639. VBIDicDad25310_3608.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_01401. MsrA. [Tree]
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
KO	K07304.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. MsrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA_DICD3

Accession

Primary (citable) accession number: Q9ZEQ8
Secondary accession number(s): E0SEC6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program