Reviewed, UniProtKB/Swiss-Prot Q9ZEQ8 (MSRA_DICD3)

Names and origin

Protein names

Recommended name:
    Peptide methionine sulfoxide reductase msrA
      Short name=Protein-methionine-S-oxide reductase
    EC=1.8.4.11
Alternative name(s):
    Peptide-methionine (S)-S-oxide reductase
      Short name=Peptide Met(O) reductase

Gene names

Name:

msrA

Organism

Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))

Taxonomic identifier

198628 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Dickeya

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity.
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-methionine (S)-S-oxide + thioredoxin. L-methionine + thioredoxin disulfide + H(2)O = L-methionine (S)-S-oxide + thioredoxin.
Sequence similarities	Belongs to the msrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW protein modification process Inferred from electronic annotation. Source: HAMAP
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 213	213	Peptide methionine sulfoxide reductase msrA		PRO_0000138549
Sites
	Active site	53	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ZEQ8-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 9EE0F02FE7428CB2	FASTA	213	23,701
	10 20 30 40 50 60 MIANFDKTQP IGQSDALPGR TTPMPVARLH VVNQHSMTHV PDHMEVAIFA MGCFWGVERL 70 80 90 100 110 120 FWQQPGVYST ASGYCGGYTP NPTYREVCTG KTGHAEAVRV VFDPAVVSYP QLLQLFWENH 130 140 150 160 170 180 NPAQGMRQGN DIGTQYRSAI YTLTTEQETA AKESYQRFQQ AMRDAGNDHD ITTEIQPAGP 190 200 210 FYYAEDEHQQ YLHKNPDGYC GLGGIGVCLP PQG

References

[1]

"The minimal gene set member msrA, encoding peptide methionine sulfoxide reductase, is a virulence determinant of the plant pathogen Erwinia chrysanthemi." Hassouni M.E., Chambost J.P., Expert D., Van Gijsegem F., Barras F. Proc. Natl. Acad. Sci. U.S.A. 96:887-892(1999) [PubMed: 9927663] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ012716 Genomic DNA. Translation: CAA10143.1.
3D structure databases
HSSP	HSSP built from PDB template 1FF3 based on UniProtKB P27110.
SMR	Q9ZEQ8. Positions 5-213.
ModBase	Search...
Family and domain databases
HAMAP	MF_01401. [Tree]
InterPro	IPR002569. MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
ProDom	PD003489. PMSR. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00401. msrA. 1 hit.
BLOCKS	Search...
ProtoNet	Search...

Entry information

Entry name

MSRA_DICD3

Accession

Primary (citable) accession number: Q9ZEQ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	May 1, 1999
Last modified:	November 4, 2008
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)