Reviewed, UniProtKB/Swiss-Prot Q9ZEP3 (CSEC_STRCO)

Names and origin

Protein names

Recommended name:
    Sensor protein cseC
    EC=2.7.13.3

Gene names

Name:	cseC
Ordered Locus Names:	SCO3359
ORF Names:	SCE94.10

Organism

Streptomyces coelicolor [Complete proteome] [HAMAP]

Taxonomic identifier

1902 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	507 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Member of the two-component regulatory system cseB/cseC involved in the stability of the cell envelope, through activation of transcription of RNA polymerase sigma-E factor. CseC functions as a membrane-associated protein kinase that phosphorylates cseB in response to changes in the cell envelope. Ref.1
Catalytic activity	ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Contains 1 HAMP domain. Contains 1 histidine kinase domain.

Ontologies

Keywords
Biological process	Two-component regulatory system
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	peptidyl-histidine phosphorylation Inferred from electronic annotation. Source: InterPro two-component signal transduction system (phosphorelay) Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW two-component sensor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 507	507	Sensor protein cseC		PRO_0000314483
Regions
	Transmembrane	60 – 80	21	Potential
	Transmembrane	183 – 203	21	Potential
	Domain	204 – 260	57	HAMP
	Domain	268 – 470	203	Histidine kinase
Amino acid modifications
	Modified residue	271	1	Phosphohistidine; by autocatalysis By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ZEP3-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: B59A28BF828207EA	FASTA	507	54,266
	10 20 30 40 50 60 MRGFFRQRRS VSPPGHPYDR TGPGEHAGPG ARTGPGGRPR VLGVRGLRAR GIRTGLRWKL 70 80 90 100 110 120 SAAIALVGAL VAIALSLVVH NAARVSMLDN ARDLADDRVL IAQRNYELSG RQNFPNAQID 130 140 150 160 170 180 DPALPPELRR KIDAGRRATY VSERPDGVTD IWAAVPLKDG HVMSLHSGFT DRSADILSDL 190 200 210 220 230 240 DQALVIGSIA VVLGGSALGV LIGGQLSRRL REAAAAANRV ASGEPDVRVR DAIGGVVRDE 250 260 270 280 290 300 TDDVARAVDA MADALQQRIE AERRVTADIA HELRTPVTGL LTAAELLPPG RPTELVLDRA 310 320 330 340 350 360 KAMRTLVEDV LEVARLDGAS ERAELQDIML GDFVSRRVAA KDPAVEVRVI HESEVTTDPR 370 380 390 400 410 420 RLERVLFNLL ANAARHGRSP VEVSVEGRVI RVRDHGPGFP EDLLAEGPSR FRTGSTDRAG 430 440 450 460 470 480 RGHGLGLTIA AGQARVLGAR LTFRNVRPAG APAHIPAEGA VAVLWLPEHA PTNTGSYPML 490 500 PDRSKSGASS SARDMSREAS QGMSRKP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A putative two-component signal transduction system regulates sigE, a sigma factor required for normal cell wall integrity in Streptomyces coelicolor A3(2)." Paget M.S.B., Leibowitz E., Buttner M.J. Mol. Microbiol. 33:97-107(1999) [PubMed: 10411727] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION IN TRANSCRIPTIONAL ACTIVATION OF SIGMA E. Strain: A3(2) / M600.
[2]	"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ131213 Genomic DNA. Translation: CAA10326.1. AL939116 Genomic DNA. Translation: CAB40859.1.
PIR	T36370.
RefSeq	NP_627567.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1098796.
GenomeReviews	Gene locus SCO3359 in contig AL645882_GR.
KEGG	sco:SCO3359.
NMPDR	fig|100226.1.peg.3319.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9ZEP3.
OMA	ERRVTAD.
Enzyme and pathway databases
BioCyc	SCOE100226:SCO3359-MON.
BRENDA	2.7.13.3. 1084.
Family and domain databases
InterPro	IPR003594. ATP_bd_ATPase. IPR003660. HAMP_linker_domain. IPR003661. Sig_transdc_His_kin_sub1_dim/P. IPR005467. Sig_transdc_His_kinase_core. [Graphical view]
Gene3D	G3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit.
Pfam	PF00672. HAMP. 1 hit. PF02518. HATPase_c. 1 hit. PF00512. HisKA. 1 hit. [Graphical view]
SMART	SM00304. HAMP. 1 hit. SM00387. HATPase_c. 1 hit. SM00388. HisKA. 1 hit. [Graphical view]
PROSITE	PS50885. HAMP. 1 hit. PS50109. HIS_KIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CSEC_STRCO

Accession

Primary (citable) accession number: Q9ZEP3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 1, 1999
Last modified:	November 3, 2009
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)