Reviewed, UniProtKB/Swiss-Prot Q9ZEE0 (THIO_RICPR)

Names and origin

Protein names

Recommended name:
    Thioredoxin
      Short name=Trx

Gene names

Name:	trxA
Ordered Locus Names:	RP002

Organism

Rickettsia prowazekii [Complete proteome] [HAMAP]

Taxonomic identifier

782 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	105 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions By similarity.
Sequence similarities	Belongs to the thioredoxin family. Contains 1 thioredoxin domain.

Ontologies

Keywords
Biological process	Electron transport Transport
Domain	Redox-active center
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW glycerol ether metabolic process Inferred from electronic annotation. Source: InterPro transport Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 105	105	Thioredoxin		PRO_0000120124
Regions
	Domain	1 – 105	105	Thioredoxin
Amino acid modifications
	Disulfide bond	30 ↔ 33		Redox-active By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ZEE0-1 [UniParc]. Last modified January 23, 2002. Version 2. Checksum: C9B1AD3BC277395C	FASTA	105	12,057
	10 20 30 40 50 60 MVNNVTDSSF KNEVLESDLP VMVDFWAEWC GPCKMLIPII DEISKELQDK VKVLKMNIDE 70 80 90 100 NPKTPSEYGI RSIPTIMLFK NGEQKDTKIG LQQKNSLLDW INKSI

References

[1]

"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed: 9823893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ235270 Genomic DNA. Translation: CAA14475.1. Different initiation.
PIR	D71707.
RefSeq	NP_220398.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	883502.
GenomeReviews	Gene locus RP002 in contig AJ235269_GR.
KEGG	rpr:RP002.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9ZEE0.
Enzyme and pathway databases
BioCyc	RPRO272947:RP002-MON.
Family and domain databases
InterPro	IPR005746. Thioredoxin. IPR017936. Thioredoxin-like. IPR012336. Thioredoxin-like_fold. IPR006662. Thioredoxin-like_subdom. IPR015467. Thioredoxin_core. IPR017937. Thioredoxin_CS. IPR013766. Thioredoxin_domain. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHER	PTHR10438. Trx. 1 hit.
Pfam	PF00085. Thioredoxin. 1 hit. [Graphical view]
PRINTS	PR00421. THIOREDOXIN.
TIGRFAMs	TIGR01068. thioredoxin. 1 hit.
PROSITE	PS00194. THIOREDOXIN_1. 1 hit. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

THIO_RICPR

Accession

Primary (citable) accession number: Q9ZEE0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 23, 2002
Last modified:	November 24, 2009
This is version 53 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)