Reviewed, UniProtKB/Swiss-Prot Q9ZED4 (FABZ_RICPR)

Names and origin

Protein names

Recommended name:
    (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase
      Short name=(3R)-hydroxymyristoyl ACP dehydrase
    EC=4.2.1.-

Gene names

Name:	fabZ
Ordered Locus Names:	RP008

Organism

Rickettsia prowazekii [Complete proteome] [HAMAP]

Taxonomic identifier

782 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	145 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in saturated fatty acids biosynthesis. HAMAP MF_00406
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the thioester dehydratase family. FabZ subfamily.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid synthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: InterPro lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hydro-lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 145	145	(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase HAMAP MF_00406		PRO_0000091721
Sites
	Active site	49	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ZED4-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 30EBB8604A6012B6	FASTA	145	16,425
	10 20 30 40 50 60 MIIAITEIMD LIPHRYPFLL VDRVLKIDPN KSIIGIKNVT VNEPQFTGHF PARPVMPGVL 70 80 90 100 110 120 MVESMAQLAA ILVAKSLDST KNKEVFLMSI ENTKFRRIVQ PGDTMHIHSV IDQQRANVWK 130 140 FSSKVMVECE IAAESKFTAM IKDKM

References

[1]

"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed: 9823893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ235270 Genomic DNA. Translation: CAA14481.1.
PIR	B71708.
RefSeq	NP_220404.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	883510.
GenomeReviews	Gene locus RP008 in contig AJ235269_GR.
KEGG	rpr:RP008.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG433282.
OMA	EFIKERR.
Enzyme and pathway databases
BioCyc	RPRO272947:RP008-MON.
Family and domain databases
HAMAP	MF_00406. [Tree]
InterPro	IPR013114. FabA_FabZ. IPR010084. FabZ. [Graphical view]
Pfam	PF07977. FabA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FABZ_RICPR

Accession

Primary (citable) accession number: Q9ZED4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	December 15, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)