Q9ZED4 (FABZ_RICPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
EC=4.2.1.59

Alternative name(s):
(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase
Short name=(3R)-hydroxymyristoyl-ACP dehydrase
Beta-hydroxyacyl-ACP dehydratase

Gene names

Name:	fabZ
Ordered Locus Names:	RP008

Organism

Rickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]

Taxonomic identifier

272947 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group › Rickettsia prowazekii

Protein attributes

Sequence length	145 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs By similarity. HAMAP-Rule MF_00406
Catalytic activity	A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O. HAMAP-Rule MF_00406
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the thioester dehydratase family. FabZ subfamily.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid biosynthesis Lipid metabolism
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	fatty acid biosynthetic process Inferred from electronic annotation. Source: HAMAP lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 145	145	3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ HAMAP-Rule MF_00406		PRO_0000091721
Sites
	Active site	49	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ZED4 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 30EBB8604A6012B6	FASTA	145	16,425
	10 20 30 40 50 60 MIIAITEIMD LIPHRYPFLL VDRVLKIDPN KSIIGIKNVT VNEPQFTGHF PARPVMPGVL 70 80 90 100 110 120 MVESMAQLAA ILVAKSLDST KNKEVFLMSI ENTKFRRIVQ PGDTMHIHSV IDQQRANVWK 130 140 FSSKVMVECE IAAESKFTAM IKDKM

References

[1]

"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ235270 Genomic DNA. Translation: CAA14481.1.
PIR	B71708.
RefSeq	NP_220404.1. NC_000963.1.
3D structure databases
ProteinModelPortal	Q9ZED4.
ModBase	Search...
Protein-protein interaction databases
STRING	272947.RP008.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAA14481; CAA14481; CAA14481.
GeneID	883510.
KEGG	rpr:RP008.
PATRIC	17900744. VBIRicPro72556_0008.
Phylogenomic databases
eggNOG	COG0764.
HOGENOM	HOG000277829.
KO	K02372.
OMA	IVEMEPG.
ProtClustDB	PRK00006.
Family and domain databases
HAMAP	MF_00406. FabZ.
InterPro	IPR013114. FabA_FabZ. IPR010084. FabZ. [Graphical view]
Pfam	PF07977. FabA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01750. fabZ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FABZ_RICPR

Accession

Primary (citable) accession number: Q9ZED4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program