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Q9ZED4

- FABZ_RICPR

UniProt

Q9ZED4 - FABZ_RICPR

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Protein

3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

Gene
fabZ, RP008
Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs By similarity.UniRule annotation

Catalytic activityi

A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei49 – 491 By similarity

GO - Molecular functioni

  1. 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity Source: UniProtKB-EC

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-HAMAP
  2. lipid A biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ (EC:4.2.1.59)
Alternative name(s):
(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase
Short name:
(3R)-hydroxymyristoyl-ACP dehydrase
Beta-hydroxyacyl-ACP dehydratase
Gene namesi
Name:fabZ
Ordered Locus Names:RP008
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1451453-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZUniRule annotationPRO_0000091721Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272947.RP008.

Structurei

3D structure databases

ProteinModelPortaliQ9ZED4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0764.
HOGENOMiHOG000277829.
KOiK02372.
OMAiAQASMFC.
OrthoDBiEOG6JTCGM.

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
HAMAPiMF_00406. FabZ.
InterProiIPR013114. FabA_FabZ.
IPR010084. FabZ.
IPR029069. HotDog_dom.
[Graphical view]
PfamiPF07977. FabA. 1 hit.
[Graphical view]
SUPFAMiSSF54637. SSF54637. 1 hit.
TIGRFAMsiTIGR01750. fabZ. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZED4-1 [UniParc]FASTAAdd to Basket

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MIIAITEIMD LIPHRYPFLL VDRVLKIDPN KSIIGIKNVT VNEPQFTGHF    50
PARPVMPGVL MVESMAQLAA ILVAKSLDST KNKEVFLMSI ENTKFRRIVQ 100
PGDTMHIHSV IDQQRANVWK FSSKVMVECE IAAESKFTAM IKDKM 145
Length:145
Mass (Da):16,425
Last modified:May 1, 1999 - v1
Checksum:i30EBB8604A6012B6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235270 Genomic DNA. Translation: CAA14481.1.
PIRiB71708.
RefSeqiNP_220404.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA14481; CAA14481; CAA14481.
GeneIDi883510.
KEGGirpr:RP008.
PATRICi17900744. VBIRicPro72556_0008.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235270 Genomic DNA. Translation: CAA14481.1 .
PIRi B71708.
RefSeqi NP_220404.1. NC_000963.1.

3D structure databases

ProteinModelPortali Q9ZED4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272947.RP008.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAA14481 ; CAA14481 ; CAA14481 .
GeneIDi 883510.
KEGGi rpr:RP008.
PATRICi 17900744. VBIRicPro72556_0008.

Phylogenomic databases

eggNOGi COG0764.
HOGENOMi HOG000277829.
KOi K02372.
OMAi AQASMFC.
OrthoDBi EOG6JTCGM.

Family and domain databases

Gene3Di 3.10.129.10. 1 hit.
HAMAPi MF_00406. FabZ.
InterProi IPR013114. FabA_FabZ.
IPR010084. FabZ.
IPR029069. HotDog_dom.
[Graphical view ]
Pfami PF07977. FabA. 1 hit.
[Graphical view ]
SUPFAMi SSF54637. SSF54637. 1 hit.
TIGRFAMsi TIGR01750. fabZ. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiFABZ_RICPR
AccessioniPrimary (citable) accession number: Q9ZED4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi