Reviewed, UniProtKB/Swiss-Prot Q9ZEC1 (ATP6_RICPR)

Names and origin

Protein names

Recommended name:
    ATP synthase subunit a
Alternative name(s):
    F-ATPase subunit 6
    ATP synthase F0 sector subunit a

Gene names

Name:	atpB
Ordered Locus Names:	RP023

Organism

Rickettsia prowazekii [Complete proteome] [HAMAP]

Taxonomic identifier

782 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	242 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane By similarity.
Subunit structure	F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the ATPase A chain family.

Ontologies

Keywords
Biological process	ATP synthesis Hydrogen ion transport Ion transport Transport
Cellular component	CF(0) Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	plasma membrane ATP synthesis coupled proton transport Inferred from electronic annotation. Source: HAMAP
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW proton-transporting ATP synthase complex, coupling factor F(o) Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	hydrogen ion transporting ATP synthase activity, rotational mechanism Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 242	242	ATP synthase subunit a HAMAP MF_01393		PRO_0000082069
Regions
	Transmembrane	29 – 49	21	Potential
	Transmembrane	84 – 104	21	Potential
	Transmembrane	114 – 134	21	Potential
	Transmembrane	140 – 160	21	Potential
	Transmembrane	189 – 209	21	Potential
	Transmembrane	210 – 230	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9ZEC1-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 488EE81DE6088613	FASTA	242	27,378
	10 20 30 40 50 60 MTHSPLIQFN IKKLIDIKMF GFDVSFTNSS IYMLLATTLS LTYLYLAFYN RKLIPSRLQV 70 80 90 100 110 120 SAEIVYNLVA DMLNQNIGIK GRKFIPLVFS LFIFILFCNL LGMTPYSFTA TSHIIVTFTL 130 140 150 160 170 180 ALLIFLTVTI VGFIKHGVSF LTLFLPHGTP VWLAPLMIVI ELFTYLARPV SLSLRLAANM 190 200 210 220 230 240 MAGHVLLKVI ASFTVSLMIY LKFLPIPLMV ILIGFEIFIA ILQAYIFTIL SCMYLNDAIN LH

References

[1]

"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed: 9823893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ235270 Genomic DNA. Translation: CAA14494.1.
PIR	G71709.
RefSeq	NP_220417.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	883548.
GenomeReviews	Gene locus RP023 in contig AJ235269_GR.
KEGG	rpr:RP023.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9ZEC1.
OMA	AFYNRKL
Enzyme and pathway databases
BioCyc	RPRO272947:RP023-MON.
BRENDA	3.6.3.14. 141977.
Family and domain databases
HAMAP	MF_01393. [Tree]
InterPro	IPR000568. ATPase_F0-cplx_asu. [Graphical view]
Gene3D	G3DSA:1.20.120.220. ATPase_F0_A. 1 hit.
PANTHER	PTHR11410. ATPase_F0_A. 1 hit.
Pfam	PF00119. ATP-synt_A. 1 hit. [Graphical view]
PRINTS	PR00123. ATPASEA.
TIGRFAMs	TIGR01131. ATP_synt_6_or_A. 1 hit.
PROSITE	PS00449. ATPASE_A. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATP6_RICPR

Accession

Primary (citable) accession number: Q9ZEC1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	November 24, 2009
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)