Reviewed, UniProtKB/Swiss-Prot Q9ZEB9 (DSB_RICPR)

Names and origin

Protein names

Recommended name:
    Putative protein-disulfide oxidoreductase RP025
    EC=1.8.-.-

Gene names

Ordered Locus Names:

RP025

Organism

Rickettsia prowazekii [Complete proteome] [HAMAP]

Taxonomic identifier

782 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	May be required for disulfide bond formation in some proteins By similarity.
Subcellular location	Periplasm By similarity.
Sequence similarities	Belongs to the thioredoxin family. DsbA subfamily. Contains 1 thioredoxin domain.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Redox-active center Signal
Molecular function	Oxidoreductase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	periplasmic space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 272	251	Putative protein-disulfide oxidoreductase RP025		PRO_0000259991
Regions
	Domain	74 – 263	190	Thioredoxin
Amino acid modifications
	Disulfide bond	116 ↔ 119		Redox-active Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9ZEB9-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 97FA84184D217E6D	FASTA	272	31,142
	10 20 30 40 50 60 MRNIFIVLIF LFLSNCSEVK AQDKKYEGKQ IIVQEPLQNN KTPQETNQES INSATKSVVH 70 80 90 100 110 120 NNDNNQTEEV LIHDSREQKK PEIRPTKVTF KIDDNDMVLG NKKSNVIVVE YFSPTCPHCA 130 140 150 160 170 180 YYHQTIFPEL KKKYIDTNKI AYVIREFIAT KQDLDAAILA RCKGDINSFI QFHNIILQQQ 190 200 210 220 230 240 DKWAYSNKYR ELLTDIGQLG GIPPEEYKQC LNSDKITATL IANTNLVAKA PKFIGTPSFF 250 260 270 VNGVQTENYS IDNISKAVDK ALDDETKKQI NF

References

[1]

"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed: 9823893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ235270 Genomic DNA. Translation: CAA14496.1.
PIR	A71710.
RefSeq	NP_220419.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	883554.
GenomeReviews	Gene locus RP025 in contig AJ235269_GR.
KEGG	rpr:RP025.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9ZEB9.
OMA	TLIANTN
Enzyme and pathway databases
BioCyc	RPRO272947:RP025-MON.
Family and domain databases
InterPro	IPR017936. Thioredoxin-like. IPR012336. Thioredoxin-like_fold. IPR017937. Thioredoxin_CS. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PROSITE	PS00194. THIOREDOXIN_1. 1 hit. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DSB_RICPR

Accession

Primary (citable) accession number: Q9ZEB9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	May 1, 1999
Last modified:	November 24, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)