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Protein

DNA replication and repair protein RecF

Gene

recF

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi33 – 408ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. single-stranded DNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA repair Source: UniProtKB-HAMAP
  2. DNA replication Source: UniProtKB-HAMAP
  3. SOS response Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair, DNA replication, SOS response

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA replication and repair protein RecF
Gene namesi
Name:recF
Ordered Locus Names:RP029
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 360360DNA replication and repair protein RecFPRO_0000196450Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272947.RP029.

Structurei

3D structure databases

ProteinModelPortaliQ9ZEB6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RecF family.Curated

Phylogenomic databases

eggNOGiCOG1195.
HOGENOMiHOG000269558.
KOiK03629.
OMAiQCSTGEQ.
OrthoDBiEOG6HTP3X.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
HAMAPiMF_00365. RecF.
InterProiIPR001238. DNA-binding_RecF.
IPR018078. DNA-binding_RecF_CS.
IPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
[Graphical view]
PfamiPF02463. SMC_N. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00611. recf. 1 hit.
PROSITEiPS00617. RECF_1. 1 hit.
PS00618. RECF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZEB6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNIFLHSLT LENYRNFKNL ELKTDNTPII LTGENGSGKT NILEAISLFY
60 70 80 90 100
PGRGLRSSKL TDICKTSEDY CKVKTLLQSK LGLAELSTHI KRSSNRRITE
110 120 130 140 150
YNASKIANNE LSKFTNMVWL TPQMEGIFTS SSTDRRKFLD RIVYNFDTKH
160 170 180 190 200
AALLNKYEYY MHERNKILAE DIRDNNWLKI IEEKMADISN NIANNRLKTI
210 220 230 240 250
RFIQQAIDDI ENEFPKADLS IDGIIEQKIL NVEGDIVNFI ITELYKTRSK
260 270 280 290 300
DKLLGRTSFG IHKSDFLVKH QKKNILAKFC STGEQKAILI AIILAEINST
310 320 330 340 350
IKLTKITPIL LLDEIFVHLD DKRRQYLMGF FNALNIQLWV TATDLDGIEN
360
FANKAQLIKL
Length:360
Mass (Da):41,489
Last modified:May 1, 1999 - v1
Checksum:i500B37B88D77A16D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235270 Genomic DNA. Translation: CAA14500.1.
PIRiE71710.
RefSeqiNP_220423.1. NC_000963.1.

Genome annotation databases

GeneIDi883560.
KEGGirpr:RP029.
PATRICi17900790. VBIRicPro72556_0029.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235270 Genomic DNA. Translation: CAA14500.1.
PIRiE71710.
RefSeqiNP_220423.1. NC_000963.1.

3D structure databases

ProteinModelPortaliQ9ZEB6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272947.RP029.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi883560.
KEGGirpr:RP029.
PATRICi17900790. VBIRicPro72556_0029.

Phylogenomic databases

eggNOGiCOG1195.
HOGENOMiHOG000269558.
KOiK03629.
OMAiQCSTGEQ.
OrthoDBiEOG6HTP3X.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
HAMAPiMF_00365. RecF.
InterProiIPR001238. DNA-binding_RecF.
IPR018078. DNA-binding_RecF_CS.
IPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
[Graphical view]
PfamiPF02463. SMC_N. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00611. recf. 1 hit.
PROSITEiPS00617. RECF_1. 1 hit.
PS00618. RECF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiRECF_RICPR
AccessioniPrimary (citable) accession number: Q9ZEB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: April 1, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.