Succinate dehydrogenase iron-sulfur subunit - Rickettsia prowazekii

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Reviewed, UniProtKB/Swiss-Prot Q9ZEA1 (DHSB_RICPR)

Last modified November 3, 2009. Version 62. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
Succinate dehydrogenase iron-sulfur subunit
EC=1.3.99.1

Gene names

Name:	sdhB
Ordered Locus Names:	RP044

Organism

Rickettsia prowazekii [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Succinate + acceptor = fumarate + reduced acceptor.
Cofactor	Binds 1 2Fe-2S cluster. Binds 1 3Fe-4S cluster. Binds 1 4Fe-4S cluster.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle.
Subunit structure	Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and an hydrophobic anchor protein.
Sequence similarities	Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. Contains 1 2Fe-2S ferredoxin-type domain. Contains 1 4Fe-4S ferredoxin-type domain.

Ontologies

Keywords
Biological process	Electron transport Transport Tricarboxylic acid cycle
Ligand	2Fe-2S 3Fe-4S 4Fe-4S Iron Iron-sulfur Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	2 iron, 2 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW 3 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW 4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW electron carrier activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW succinate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

261

Succinate dehydrogenase iron-sulfur subunit

PRO_0000158691

Regions

Domain

92

2Fe-2S ferredoxin-type

Domain

31

4Fe-4S ferredoxin-type

Sites

Metal binding

1

Iron-sulfur 1 (2Fe-2S) By similarity

Metal binding

1

Iron-sulfur 1 (2Fe-2S) By similarity

Metal binding

1

Iron-sulfur 1 (2Fe-2S) By similarity

Metal binding

1

Iron-sulfur 1 (2Fe-2S) By similarity

Metal binding

1

Iron-sulfur 2 (4Fe-4S) By similarity

Metal binding

1

Iron-sulfur 2 (4Fe-4S) By similarity

Metal binding

1

Iron-sulfur 2 (4Fe-4S) By similarity

Metal binding

1

Iron-sulfur 3 (3Fe-4S) By similarity

Metal binding

1

Iron-sulfur 3 (3Fe-4S) By similarity

Metal binding

1

Iron-sulfur 3 (3Fe-4S) By similarity

Metal binding

1

Iron-sulfur 2 (4Fe-4S) By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q9ZEA1-1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: AFAB638FFF0F44A1
Show »

261

29,572

        10         20         30         40         50         60 
MVELRLPSNS VVKKGREHKA QQKMLKPRKV KVYRYDPDLD ENPTIDSFEI DLSKTGPMVL 

        70         80         90        100        110        120 
DALIKIKNEI DSTLTFRRSC REGICGSCAM NIDGTNTLAC IKPIEDISGD IKIYPLPHMK 

       130        140        150        160        170        180 
VVKDLVPDMS HFYAQYESIE PWLKNDSPAP SNSERLQSIK DREKLDGLYE CILCACCSTS 

       190        200        210        220        230        240 
CPSYWWNGDK YLGPAILLQA YRWIADSRDD NTGARLEALE DPFKLYRCHT IMNCTKTCPK 

       250        260 
GLNPAKAIGR VKNLIAERHG V

References

[1]

"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed: 9823893] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.

Cross-references

Sequence databases
	AJ235270 Genomic DNA. Translation: CAA14515.1.
PIR	D71712.
RefSeq	NP_220438.1.
3D structure databases
HSSP	HSSP built from PDB template 1NEK based on UniProtKB P07014.
ModBase	Search...
Genome annotation databases
GeneID	883577.
GenomeReviews	Gene locus RP044 in contig AJ235269_GR.
KEGG	rpr:RP044.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9ZEA1.
OMA	ADSRDDN.
Enzyme and pathway databases
BioCyc	RPRO272947:RP044-MON.
BRENDA	1.3.99.1. 141977.
Family and domain databases
InterPro	IPR006058. 2Fe2S_fd_BS. IPR017896. 4Fe4S_Fe-S-bd. IPR017900. 4Fe4S_Fe_S_CS. IPR012675. b-grasp_ferredoxin-like. IPR001041. Ferredoxin. IPR012285. Fum_reductase_C. IPR004489. Succ_DH/fum_Rdtase_Fe-S. [Graphical view]
Gene3D	G3DSA:3.10.20.30. Ferredoxin_fold. 1 hit. G3DSA:1.10.1060.10. Fum_reductase_C. 1 hit.
TIGRFAMs	TIGR00384. dhsB. 1 hit.
PROSITE	PS00197. 2FE2S_FER_1. 1 hit. PS51085. 2FE2S_FER_2. 1 hit. PS00198. 4FE4S_FER_1. 1 hit. PS51379. 4FE4S_FER_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHSB_RICPR

Accession

Primary (citable) accession number: Q9ZEA1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	November 3, 2009
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents