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Protein

Succinate dehydrogenase iron-sulfur subunit

Gene

sdhB

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

Protein has several cofactor binding sites:

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (bacterial route).
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase iron-sulfur subunit (sdhB), Succinate dehydrogenase flavoprotein subunit (sdhA)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (bacterial route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi80Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi85Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi100Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi171Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi174Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi177Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi181Iron-sulfur 3 (3Fe-4S)By similarity1
Binding sitei186Ubiquinone; shared with SdhD subunitBy similarity1
Metal bindingi228Iron-sulfur 3 (3Fe-4S)By similarity1
Metal bindingi234Iron-sulfur 3 (3Fe-4S)By similarity1
Metal bindingi238Iron-sulfur 2 (4Fe-4S)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport, Tricarboxylic acid cycle
Ligand2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciRPRO272947:G1GT0-44-MONOMER
UniPathwayiUPA00223; UER01005

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase iron-sulfur subunit (EC:1.3.5.1)
Gene namesi
Name:sdhB
Ordered Locus Names:RP044
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000002480 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001586911 – 261Succinate dehydrogenase iron-sulfur subunitAdd BLAST261

Interactioni

Subunit structurei

Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and a hydrophobic anchor protein.

Protein-protein interaction databases

STRINGi272947.RP044

Structurei

3D structure databases

ProteinModelPortaliQ9ZEA1
SMRiQ9ZEA1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 1192Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST92
Domaini161 – 1914Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd BLAST31

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105E33 Bacteria
COG0479 LUCA
HOGENOMiHOG000160590
KOiK00240
OMAiDGQYFGP

Family and domain databases

CDDicd00207 fer2, 1 hit
Gene3Di1.10.1060.101 hit
3.10.20.301 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR006058 2Fe2S_fd_BS
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR012675 Beta-grasp_dom_sf
IPR009051 Helical_ferredxn
IPR004489 Succ_DH/fum_Rdtase_Fe-S
IPR025192 Succ_DH/fum_Rdtase_N
PfamiView protein in Pfam
PF13085 Fer2_3, 1 hit
SUPFAMiSSF46548 SSF46548, 1 hit
SSF54292 SSF54292, 1 hit
TIGRFAMsiTIGR00384 dhsB, 1 hit
PROSITEiView protein in PROSITE
PS00197 2FE2S_FER_1, 1 hit
PS51085 2FE2S_FER_2, 1 hit
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ZEA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVELRLPSNS VVKKGREHKA QQKMLKPRKV KVYRYDPDLD ENPTIDSFEI
60 70 80 90 100
DLSKTGPMVL DALIKIKNEI DSTLTFRRSC REGICGSCAM NIDGTNTLAC
110 120 130 140 150
IKPIEDISGD IKIYPLPHMK VVKDLVPDMS HFYAQYESIE PWLKNDSPAP
160 170 180 190 200
SNSERLQSIK DREKLDGLYE CILCACCSTS CPSYWWNGDK YLGPAILLQA
210 220 230 240 250
YRWIADSRDD NTGARLEALE DPFKLYRCHT IMNCTKTCPK GLNPAKAIGR
260
VKNLIAERHG V
Length:261
Mass (Da):29,572
Last modified:May 1, 1999 - v1
Checksum:iAFAB638FFF0F44A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235270 Genomic DNA Translation: CAA14515.1
PIRiD71712
RefSeqiNP_220438.1, NC_000963.1
WP_004596634.1, NC_000963.1

Genome annotation databases

EnsemblBacteriaiCAA14515; CAA14515; CAA14515
GeneIDi883577
KEGGirpr:RP044
PATRICifig|272947.5.peg.45

Similar proteinsi

Entry informationi

Entry nameiSDHB_RICPR
AccessioniPrimary (citable) accession number: Q9ZEA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: February 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome