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Q9ZEA1 (SDHB_RICPR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Succinate dehydrogenase iron-sulfur subunit

EC=1.3.5.1
Gene names
Name:sdhB
Ordered Locus Names:RP044
OrganismRickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]
Taxonomic identifier272947 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Succinate + a quinone = fumarate + a quinol.

Cofactor

Binds 1 2Fe-2S cluster.

Binds 1 3Fe-4S cluster.

Binds 1 4Fe-4S cluster.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (bacterial route): step 1/1.

Subunit structure

Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and a hydrophobic anchor protein.

Sequence similarities

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

Contains 1 2Fe-2S ferredoxin-type domain.

Contains 1 4Fe-4S ferredoxin-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261Succinate dehydrogenase iron-sulfur subunit
PRO_0000158691

Regions

Domain28 – 119922Fe-2S ferredoxin-type
Domain161 – 191314Fe-4S ferredoxin-type

Sites

Metal binding801Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding851Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1001Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1711Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1741Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1771Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1811Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2281Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2341Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2381Iron-sulfur 2 (4Fe-4S) By similarity
Binding site1861Ubiquinone; shared with SdhD subunit By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ZEA1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: AFAB638FFF0F44A1

FASTA26129,572
        10         20         30         40         50         60 
MVELRLPSNS VVKKGREHKA QQKMLKPRKV KVYRYDPDLD ENPTIDSFEI DLSKTGPMVL 

        70         80         90        100        110        120 
DALIKIKNEI DSTLTFRRSC REGICGSCAM NIDGTNTLAC IKPIEDISGD IKIYPLPHMK 

       130        140        150        160        170        180 
VVKDLVPDMS HFYAQYESIE PWLKNDSPAP SNSERLQSIK DREKLDGLYE CILCACCSTS 

       190        200        210        220        230        240 
CPSYWWNGDK YLGPAILLQA YRWIADSRDD NTGARLEALE DPFKLYRCHT IMNCTKTCPK 

       250        260 
GLNPAKAIGR VKNLIAERHG V 

« Hide

References

[1]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ235270 Genomic DNA. Translation: CAA14515.1.
PIRD71712.
RefSeqNP_220438.1. NC_000963.1.

3D structure databases

ProteinModelPortalQ9ZEA1.
SMRQ9ZEA1. Positions 28-256.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272947.RP044.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAA14515; CAA14515; CAA14515.
GeneID883577.
KEGGrpr:RP044.
PATRIC17900822. VBIRicPro72556_0045.

Phylogenomic databases

eggNOGCOG0479.
HOGENOMHOG000160590.
KOK00240.
OMAQYEKIRP.
OrthoDBEOG6CK7MG.

Enzyme and pathway databases

UniPathwayUPA00223; UER01005.

Family and domain databases

Gene3D3.10.20.30. 1 hit.
InterProIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsTIGR00384. dhsB. 1 hit.
PROSITEPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSDHB_RICPR
AccessionPrimary (citable) accession number: Q9ZEA1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways