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Q9ZEA1

- SDHB_RICPR

UniProt

Q9ZEA1 - SDHB_RICPR

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Protein

Succinate dehydrogenase iron-sulfur subunit

Gene
sdhB, RP044
Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

Binds 1 2Fe-2S cluster.
Binds 1 3Fe-4S cluster.
Binds 1 4Fe-4S cluster.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi80 – 801Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi85 – 851Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi100 – 1001Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi171 – 1711Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi174 – 1741Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi177 – 1771Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi181 – 1811Iron-sulfur 3 (3Fe-4S) By similarity
Binding sitei186 – 1861Ubiquinone; shared with SdhD subunit By similarity
Metal bindingi228 – 2281Iron-sulfur 3 (3Fe-4S) By similarity
Metal bindingi234 – 2341Iron-sulfur 3 (3Fe-4S) By similarity
Metal bindingi238 – 2381Iron-sulfur 2 (4Fe-4S) By similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. 3 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  3. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  4. electron carrier activity Source: InterPro
  5. metal ion binding Source: UniProtKB-KW
  6. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00223; UER01005.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase iron-sulfur subunit (EC:1.3.5.1)
Gene namesi
Name:sdhB
Ordered Locus Names:RP044
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Succinate dehydrogenase iron-sulfur subunitPRO_0000158691Add
BLAST

Interactioni

Subunit structurei

Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and a hydrophobic anchor protein.

Protein-protein interaction databases

STRINGi272947.RP044.

Structurei

3D structure databases

ProteinModelPortaliQ9ZEA1.
SMRiQ9ZEA1. Positions 28-256.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 119922Fe-2S ferredoxin-typeAdd
BLAST
Domaini161 – 191314Fe-4S ferredoxin-typeAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0479.
HOGENOMiHOG000160590.
KOiK00240.
OMAiQYEKIRP.
OrthoDBiEOG6CK7MG.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamiPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZEA1-1 [UniParc]FASTAAdd to Basket

« Hide

MVELRLPSNS VVKKGREHKA QQKMLKPRKV KVYRYDPDLD ENPTIDSFEI    50
DLSKTGPMVL DALIKIKNEI DSTLTFRRSC REGICGSCAM NIDGTNTLAC 100
IKPIEDISGD IKIYPLPHMK VVKDLVPDMS HFYAQYESIE PWLKNDSPAP 150
SNSERLQSIK DREKLDGLYE CILCACCSTS CPSYWWNGDK YLGPAILLQA 200
YRWIADSRDD NTGARLEALE DPFKLYRCHT IMNCTKTCPK GLNPAKAIGR 250
VKNLIAERHG V 261
Length:261
Mass (Da):29,572
Last modified:May 1, 1999 - v1
Checksum:iAFAB638FFF0F44A1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235270 Genomic DNA. Translation: CAA14515.1.
PIRiD71712.
RefSeqiNP_220438.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA14515; CAA14515; CAA14515.
GeneIDi883577.
KEGGirpr:RP044.
PATRICi17900822. VBIRicPro72556_0045.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235270 Genomic DNA. Translation: CAA14515.1 .
PIRi D71712.
RefSeqi NP_220438.1. NC_000963.1.

3D structure databases

ProteinModelPortali Q9ZEA1.
SMRi Q9ZEA1. Positions 28-256.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272947.RP044.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAA14515 ; CAA14515 ; CAA14515 .
GeneIDi 883577.
KEGGi rpr:RP044.
PATRICi 17900822. VBIRicPro72556_0045.

Phylogenomic databases

eggNOGi COG0479.
HOGENOMi HOG000160590.
KOi K00240.
OMAi QYEKIRP.
OrthoDBi EOG6CK7MG.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01005 .

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view ]
Pfami PF13085. Fer2_3. 1 hit.
[Graphical view ]
SUPFAMi SSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsi TIGR00384. dhsB. 1 hit.
PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiSDHB_RICPR
AccessioniPrimary (citable) accession number: Q9ZEA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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