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Q9ZEA1

- SDHB_RICPR

UniProt

Q9ZEA1 - SDHB_RICPR

Protein

Succinate dehydrogenase iron-sulfur subunit

Gene

sdhB

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Succinate + a quinone = fumarate + a quinol.

    Cofactori

    Binds 1 2Fe-2S cluster.
    Binds 1 3Fe-4S cluster.
    Binds 1 4Fe-4S cluster.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi80 – 801Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi85 – 851Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi100 – 1001Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi171 – 1711Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi174 – 1741Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi177 – 1771Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi181 – 1811Iron-sulfur 3 (3Fe-4S)By similarity
    Binding sitei186 – 1861Ubiquinone; shared with SdhD subunitBy similarity
    Metal bindingi228 – 2281Iron-sulfur 3 (3Fe-4S)By similarity
    Metal bindingi234 – 2341Iron-sulfur 3 (3Fe-4S)By similarity
    Metal bindingi238 – 2381Iron-sulfur 2 (4Fe-4S)By similarity

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
    2. 3 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    3. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    4. electron carrier activity Source: InterPro
    5. metal ion binding Source: UniProtKB-KW
    6. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    GO - Biological processi

    1. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport, Tricarboxylic acid cycle

    Keywords - Ligandi

    2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00223; UER01005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinate dehydrogenase iron-sulfur subunit (EC:1.3.5.1)
    Gene namesi
    Name:sdhB
    Ordered Locus Names:RP044
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 261261Succinate dehydrogenase iron-sulfur subunitPRO_0000158691Add
    BLAST

    Interactioni

    Subunit structurei

    Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and a hydrophobic anchor protein.

    Protein-protein interaction databases

    STRINGi272947.RP044.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZEA1.
    SMRiQ9ZEA1. Positions 28-256.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 119922Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini161 – 191314Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
    Contains 1 4Fe-4S ferredoxin-type domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0479.
    HOGENOMiHOG000160590.
    KOiK00240.
    OMAiQYEKIRP.
    OrthoDBiEOG6CK7MG.

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    InterProiIPR001041. 2Fe-2S_ferredoxin-type.
    IPR006058. 2Fe2S_fd_BS.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR012675. Beta-grasp_dom.
    IPR009051. Helical_ferredxn.
    IPR004489. Succ_DH/fum_Rdtase_Fe-S.
    IPR025192. Succ_DH/fum_Rdtase_N.
    [Graphical view]
    PfamiPF13085. Fer2_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF46548. SSF46548. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsiTIGR00384. dhsB. 1 hit.
    PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
    PS51085. 2FE2S_FER_2. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZEA1-1 [UniParc]FASTAAdd to Basket

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    MVELRLPSNS VVKKGREHKA QQKMLKPRKV KVYRYDPDLD ENPTIDSFEI    50
    DLSKTGPMVL DALIKIKNEI DSTLTFRRSC REGICGSCAM NIDGTNTLAC 100
    IKPIEDISGD IKIYPLPHMK VVKDLVPDMS HFYAQYESIE PWLKNDSPAP 150
    SNSERLQSIK DREKLDGLYE CILCACCSTS CPSYWWNGDK YLGPAILLQA 200
    YRWIADSRDD NTGARLEALE DPFKLYRCHT IMNCTKTCPK GLNPAKAIGR 250
    VKNLIAERHG V 261
    Length:261
    Mass (Da):29,572
    Last modified:May 1, 1999 - v1
    Checksum:iAFAB638FFF0F44A1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235270 Genomic DNA. Translation: CAA14515.1.
    PIRiD71712.
    RefSeqiNP_220438.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA14515; CAA14515; CAA14515.
    GeneIDi883577.
    KEGGirpr:RP044.
    PATRICi17900822. VBIRicPro72556_0045.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235270 Genomic DNA. Translation: CAA14515.1 .
    PIRi D71712.
    RefSeqi NP_220438.1. NC_000963.1.

    3D structure databases

    ProteinModelPortali Q9ZEA1.
    SMRi Q9ZEA1. Positions 28-256.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP044.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA14515 ; CAA14515 ; CAA14515 .
    GeneIDi 883577.
    KEGGi rpr:RP044.
    PATRICi 17900822. VBIRicPro72556_0045.

    Phylogenomic databases

    eggNOGi COG0479.
    HOGENOMi HOG000160590.
    KOi K00240.
    OMAi QYEKIRP.
    OrthoDBi EOG6CK7MG.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER01005 .

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    InterProi IPR001041. 2Fe-2S_ferredoxin-type.
    IPR006058. 2Fe2S_fd_BS.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR012675. Beta-grasp_dom.
    IPR009051. Helical_ferredxn.
    IPR004489. Succ_DH/fum_Rdtase_Fe-S.
    IPR025192. Succ_DH/fum_Rdtase_N.
    [Graphical view ]
    Pfami PF13085. Fer2_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46548. SSF46548. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsi TIGR00384. dhsB. 1 hit.
    PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
    PS51085. 2FE2S_FER_2. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.

    Entry informationi

    Entry nameiSDHB_RICPR
    AccessioniPrimary (citable) accession number: Q9ZEA1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3