Q9ZE97 (YIDC_RICPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Membrane protein insertase YidC

Alternative name(s):
Foldase YidC
Membrane integrase YidC
Membrane protein YidC

Gene names

Name:	yidC
Ordered Locus Names:	RP048

Organism

Rickettsia prowazekii (strain Madrid E)

Taxonomic identifier

272947 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	560 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins By similarity.
Subunit structure	Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_01810.
Sequence similarities	Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Chaperone
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein insertion into membrane Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 560	560	Membrane protein insertase YidC		PRO_0000124750
Regions
	Transmembrane	5 – 25	21	Helical; Potential
	Transmembrane	334 – 354	21	Helical; Potential
	Transmembrane	357 – 377	21	Helical; Potential
	Transmembrane	431 – 451	21	Helical; Potential
	Transmembrane	476 – 496	21	Helical; Potential
	Transmembrane	522 – 542	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9ZE97 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 80D96C066A78DEA8	FASTA	560	64,433
	10 20 30 40 50 60 MNNNIINLIA AVVLSLSIIF GWQYFFVKPE QKKQQQRIAM HKSENLNKQK LKALAEPASD 70 80 90 100 110 120 IAVQEASQVQ RIKIESESLT GSIALKGLRF DDLILKKYKQ DLSQNSPAVR LFSPANTENA 130 140 150 160 170 180 YFAEIGLVSN LNSVKLPNSN TVWNSDSEVL SPEKPVNLFW INEDGIKFLV TITVDKNYLF 190 200 210 220 230 240 TIEQTIINNS DKELPVQSYG LINRKYISLE KAVNILHQGP IGCIDENLKE YSYDDIKDKK 250 260 270 280 290 300 STKFALSKVD WIGITDKYWL SSLIPDKSSR YSSNFNYALK QGTERYQVDF ISPVQVIKPG 310 320 330 340 350 360 ENLSIKSRIF AGAKKVDLLD EYEKSYDIKL FDRAIDFGWF YIITKPVFYA MNFFYGYVGN 370 380 390 400 410 420 FGISILIVTV IIKLLMFTLA NKSYRSMKKM KNLQPEIDRI KNLYNNDKAR LNQEIMALYK 430 440 450 460 470 480 KEKVNPVAGC LPILVQIPVF FSIYKVLYVT IEMRQAPFFG WIKDLSSPDP TTIFNLFGLL 490 500 510 520 530 540 PFAPPSFLMI GAWPILMAIT MFLHQKMSPE LADPIQAQVM KFMPLIFLFM FSSFPVGLLI 550 560 YWSWNNILSI IQQYYINKFN

References

[1]

"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed: 9823893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ235270 Genomic DNA. Translation: CAA14519.1.
PIR	H71712.
RefSeq	NP_220442.1. NC_000963.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	883587.
GenomeReviews	Gene locus RP048 in contig AJ235269_GR.
KEGG	rpr:RP048.
PATRIC	17900830. VBIRicPro72556_0049.
Phylogenomic databases
HOGENOM	HBG507812.
OMA	FVTIEMR.
ProtClustDB	PRK01318.
Enzyme and pathway databases
BioCyc	RPRO272947:RP048-MONOMER.
Family and domain databases
HAMAP	MF_01810. YidC_type1. [Tree]
InterPro	IPR019998. Membr_insert_OxaA/YidC_bac. IPR001708. Membrane_insertion_OxaA/YidC. [Graphical view]
KO	K03217.
PANTHER	PTHR12428. Innermemb_insert. 1 hit.
Pfam	PF02096. 60KD_IMP. 1 hit. [Graphical view]
PRINTS	PR00701. 60KDINNERMP. PR01900. YIDCPROTEIN.
TIGRFAMs	TIGR03593. YidC_nterm. 1 hit. TIGR03592. YidC_oxa1_C. 1 hit.
ProtoNet	Search...

Entry information

Entry name

YIDC_RICPR

Accession

Primary (citable) accession number: Q9ZE97

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 21, 2003
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program