Reviewed, UniProtKB/Swiss-Prot Q9ZE97 (OXAA_RICPR)

Names and origin

Protein names

Recommended name:
    Inner membrane protein oxaA

Gene names

Name:	oxaA
Ordered Locus Names:	RP048

Organism

Rickettsia prowazekii [Complete proteome] [HAMAP]

Taxonomic identifier

782 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	560 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Required for the insertion of integral membrane proteins into the membrane. Probably plays an essential role in the integration of proteins of the respiratory chain complexes. Involved in integration of membrane proteins that insert dependently and independently of the Sec translocase complex By similarity.
Subunit structure	Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the OXA1/oxaA family. Type 1 subfamily.

Ontologies

Keywords
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein insertion into membrane Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 560	560	Inner membrane protein oxaA HAMAP MF_01810		PRO_0000124750
Regions
	Transmembrane	5 – 27	23	Potential
	Transmembrane	337 – 359	23	Potential
	Transmembrane	363 – 380	18	Potential
	Transmembrane	429 – 451	23	Potential
	Transmembrane	482 – 504	23	Potential
	Transmembrane	525 – 544	20	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9ZE97-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 80D96C066A78DEA8	FASTA	560	64,433
	10 20 30 40 50 60 MNNNIINLIA AVVLSLSIIF GWQYFFVKPE QKKQQQRIAM HKSENLNKQK LKALAEPASD 70 80 90 100 110 120 IAVQEASQVQ RIKIESESLT GSIALKGLRF DDLILKKYKQ DLSQNSPAVR LFSPANTENA 130 140 150 160 170 180 YFAEIGLVSN LNSVKLPNSN TVWNSDSEVL SPEKPVNLFW INEDGIKFLV TITVDKNYLF 190 200 210 220 230 240 TIEQTIINNS DKELPVQSYG LINRKYISLE KAVNILHQGP IGCIDENLKE YSYDDIKDKK 250 260 270 280 290 300 STKFALSKVD WIGITDKYWL SSLIPDKSSR YSSNFNYALK QGTERYQVDF ISPVQVIKPG 310 320 330 340 350 360 ENLSIKSRIF AGAKKVDLLD EYEKSYDIKL FDRAIDFGWF YIITKPVFYA MNFFYGYVGN 370 380 390 400 410 420 FGISILIVTV IIKLLMFTLA NKSYRSMKKM KNLQPEIDRI KNLYNNDKAR LNQEIMALYK 430 440 450 460 470 480 KEKVNPVAGC LPILVQIPVF FSIYKVLYVT IEMRQAPFFG WIKDLSSPDP TTIFNLFGLL 490 500 510 520 530 540 PFAPPSFLMI GAWPILMAIT MFLHQKMSPE LADPIQAQVM KFMPLIFLFM FSSFPVGLLI 550 560 YWSWNNILSI IQQYYINKFN

References

[1]

"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed: 9823893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ235270 Genomic DNA. Translation: CAA14519.1.
PIR	H71712.
RefSeq	NP_220442.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	883587.
GenomeReviews	Gene locus RP048 in contig AJ235269_GR.
KEGG	rpr:RP048.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9ZE97.
OMA	FVTIEMR
Enzyme and pathway databases
BioCyc	RPRO272947:RP048-MON.
Family and domain databases
HAMAP	MF_01810. [Tree]
InterPro	IPR020001. Membrane_insert_OxaA/YidC_core. IPR001708. Membrane_insertion_OxaA/YidC. IPR013308. Membrane_insertion_YidC. IPR019998. Membrane_insertion_YidC/OxoA_N. [Graphical view]
PANTHER	PTHR12428. Innermemb_insert. 1 hit.
Pfam	PF02096. 60KD_IMP. 1 hit. [Graphical view]
PRINTS	PR00701. 60KDINNERMP. PR01900. YIDCPROTEIN.
TIGRFAMs	TIGR03593. YidC_nterm. 1 hit. TIGR03592. YidC_oxa1_C. 1 hit.
ProtoNet	Search...

Entry information

Entry name

OXAA_RICPR

Accession

Primary (citable) accession number: Q9ZE97

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 21, 2003
Last sequence update:	May 1, 1999
Last modified:	November 3, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)