Reviewed, UniProtKB/Swiss-Prot Q9ZE84 (KDSA_RICPR)

Names and origin

Protein names

Recommended name:
    2-dehydro-3-deoxyphosphooctonate aldolase
    EC=2.5.1.55
Alternative name(s):
    Phospho-2-dehydro-3-deoxyoctonate aldolase
    3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase
    KDO-8-phosphate synthetase
      Short name=KDO 8-P synthase
      Short name=KDOPS

Gene names

Name:	kdsA
Ordered Locus Names:	RP062

Organism

Rickettsia prowazekii [Complete proteome] [HAMAP]

Taxonomic identifier

782 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	275 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate. HAMAP MF_00056
Pathway	Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 2/3. HAMAP MF_00056 Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP MF_00056
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the kdsA family.

Ontologies

Keywords
Biological process	Lipopolysaccharide biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-deoxy-8-phosphooctulonate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 275	275	2-dehydro-3-deoxyphosphooctonate aldolase HAMAP MF_00056		PRO_0000187160

Sequences

	Sequence		Length	Mass (Da)
	Q9ZE84-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 47F3D76B830746C1	FASTA	275	30,246
	10 20 30 40 50 60 MKKVVKLNNI KIGNDLQFVL IAGPCQIEGK DHALFMAEKL MKLTSKLSIP FIYKSSFDKA 70 80 90 100 110 120 NRTSINGIRG LGIEKGLEIL SKVKSEFDCP IITDVHSESQ CIETAKVVDI LQIPAFLCRQ 130 140 150 160 170 180 TDLLKAAAKT GKIVKVKKGQ FLAPWDMKNV QKKLEVFGAK DILFTERGSC FGYNNLVSDM 190 200 210 220 230 240 RSLAIMSELN VPVVFDATHS VQQPGGRGGS SGGERKYVEL LAKAAISVGI AGIYMEVHQD 250 260 270 PDNAPSDGPC MIKLDNLESI LIKLKKYDKI TKEIV

References

[1]

"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed: 9823893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ235270 Genomic DNA. Translation: CAA14533.1.
PIR	F71714.
RefSeq	NP_220456.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	883617.
GenomeReviews	Gene locus RP062 in contig AJ235269_GR.
KEGG	rpr:RP062.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9ZE84.
OMA	LAPWDMG
Enzyme and pathway databases
BioCyc	RPRO272947:RP062-MON.
BRENDA	2.5.1.55. 141977.
Family and domain databases
HAMAP	MF_00056. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR006218. DAHP1/KDSA. IPR006269. KDO8P_synthase. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR21057:SF2. KDO8P_synthase. 1 hit.
Pfam	PF00793. DAHP_synth_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR01362. KDO8P_synth. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KDSA_RICPR

Accession

Primary (citable) accession number: Q9ZE84

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	November 24, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)