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Q9ZE81 (SYR_RICPR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase
EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:RP065
OrganismRickettsia prowazekii (strain Madrid E)
Taxonomic identifier272947 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length576 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP MF_00123

Subunit structure

Monomer By similarity. HAMAP MF_00123

Subcellular location

Cytoplasm HAMAP MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 576576Arginine--tRNA ligase HAMAP MF_00123
PRO_0000151600

Regions

Motif126 – 13611"HIGH" region HAMAP MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q9ZE81 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: ECBAEB63C456F1BF

FASTA57665,204
        10         20         30         40         50         60 
MNIFNQLKQD IIAASQKLYN NKEIANTATI ETPKDSFNGD LSSNIAMIIA SKESIAPREV 

        70         80         90        100        110        120 
ALKFKEVLVT LPYIASIEIA GPGFINFTIK AESWQAAIKD ILQHEEKFFE IDIDKNSNIN 

       130        140        150        160        170        180 
IEYVSANPTG PMHIGHARGA VYGDVLARIL QKVGYSVTKE YYVNDAGSQI NDLVSTVLLR 

       190        200        210        220        230        240 
YKEALGEPIT IPVGLYPGEY LIPLGEILSK EYGNKLLTMN DVERFKIIKS FAVEKMLDLN 

       250        260        270        280        290        300 
RKDLADLGIK HDVFFSEQSL YDKGEIEKTV KLLERMGLIY EGTLPAPKGK VHEDWEYRVQ 

       310        320        330        340        350        360 
KLFKSTNYGD SQDRPIEKAD GSWSYFASDL AYAKDKIDRG ANHLIYVLGA DHSGYVKRIE 

       370        380        390        400        410        420 
AIVKALGQEK VKVDVKICQL VNFVENGVPI KMSKRLGSFA SVQDVNKEVG KDIIRFMMLT 

       430        440        450        460        470        480 
RQNDKPLDFD LVKVKEQSRE NPIFYVQYAH VRTKSILSKA RELMPEAYNS FKEGKYNLSL 

       490        500        510        520        530        540 
LSSEEEIEII KLLAAWTKTL EASVKYFEPH RIAFYLINLA SKFHSMWNFG KENSDYRFII 

       550        560        570 
ENNKELTLAR LALASVIQKI IASGLEVIGV EPMVTM

« Hide

References

[1]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed: 9823893] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ235270 Genomic DNA. Translation: CAA14536.1.
PIRA71715.
RefSeqNP_220459.1. NC_000963.1.

3D structure databases

ProteinModelPortalQ9ZE81.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID883631.
GenomeReviewsGene locus RP065 in contig AJ235269_GR.
KEGGrpr:RP065.
PATRIC17900864. VBIRicPro72556_0066.

Phylogenomic databases

HOGENOMHBG695395.
OMARMKAAMK.
ProtClustDBPRK01611.

Enzyme and pathway databases

BioCycRPRO272947:RP065-MONOMER.

Family and domain databases

HAMAPMF_00123. Arg_tRNA_synth.
[Tree]
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-synth_Ia.
IPR015945. Arg-tRNA-synth_Ia_core.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
Gene3DG3DSA:3.30.1360.70. Arg-tRNA-synth_Ic_N. 1 hit.
G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KOK01887.
PANTHERPTHR11956. Arg_tRNA-synt_1c. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF55190. Arg-tRNA-synth_Ic_N. 1 hit.
SSF47323. tRNAsyn_1a_bind. 1 hit.
TIGRFAMsTIGR00456. ArgS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_RICPR
AccessionPrimary (citable) accession number: Q9ZE81
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names

SIMILARITY comments

Index of protein domains and families

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