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Q9ZE79 (PARC_RICPR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA topoisomerase 4 subunit A

EC=5.99.1.3
Alternative name(s):
Topoisomerase IV subunit A
Gene names
Name:parC
Ordered Locus Names:RP067
OrganismRickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]
Taxonomic identifier272947 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length738 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule By similarity. HAMAP-Rule MF_00936

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP-Rule MF_00936

Subunit structure

Heterotetramer composed of ParC and ParE By similarity. HAMAP-Rule MF_00936

Subcellular location

Cell membrane; Peripheral membrane protein By similarity HAMAP-Rule MF_00936.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 738738DNA topoisomerase 4 subunit A HAMAP-Rule MF_00936
PRO_0000145406

Sites

Active site1201O-(5'-phospho-DNA)-tyrosine intermediate By similarity
Site401Interaction with DNA By similarity
Site761Interaction with DNA By similarity
Site781Interaction with DNA By similarity
Site1191Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ZE79 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 166B9B88C76E52A8

FASTA73883,348
        10         20         30         40         50         60 
MKEAKIENID FGNALSERYL AYALSTIMSR SLPDVRDGLK PVHRRLLYAM LQLRLEPNSG 

        70         80         90        100        110        120 
YKKCARVVGD VIGKYHPHGD VAVYDTLVRL AQHFSLRYPL IDGQGNFGSI DGDNAAAMRY 

       130        140        150        160        170        180 
TESRMTEICM LLMEDIDKDT VDFRSTYDDS DLEPVIMPAS FPNLLANGSE GIAVGMATNI 

       190        200        210        220        230        240 
PPHNLHELCD ALLYLIDNPQ AGINDIMNFI KGPDFPTGGI IIDKAEVINA AYTTGRGSFR 

       250        260        270        280        290        300 
VRSRWEKEEL SYGTYQIVVT EIPYQIQKSK LIEQIAILLK DKKIPLISSI RDESTDIIRV 

       310        320        330        340        350        360 
VIEPRDRSCD PQIVMESLFK LTNLESRIQL NMNVIGSNNV PRVMNILEIL QEFLVHRKNI 

       370        380        390        400        410        420 
IIRRSTYLLN KIKQRLEILK VLRIVYLNLD EIIEIIREED EPKTIIMERF KISAIQVEVI 

       430        440        450        460        470        480 
LNTRLRSLQK LEEHAIIDEH SNLQKQQAIL EKILKNHKEL WQIVKKEIKA VQTKFGLNTI 

       490        500        510        520        530        540 
IGARRTSFEE VDLTNQVVDI TAFITKEPIT IICSKMGWVR SLKGHNTDLS TIKYKEGDTE 

       550        560        570        580        590        600 
KFIIEAYTTD KILIISSKGR FFTLLADNIS KGKGTGGVSI KLLVDIGNND ITNILVYKPN 

       610        620        630        640        650        660 
QLLLLASSIG KGFLVNSNEV IAQTKTGKQI MNIPEGYSCI ACLPVNGDSI ACIGESRRLL 

       670        680        690        700        710        720 
VFNIDEIPEM KKGQGVVLQR FKNAKLLDIK IFNKQDGLSW NDGTKIQLEK NIVAFLGKRG 

       730 
GFGTFPPIGF PKNNRFSP 

« Hide

References

[1]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ235270 Genomic DNA. Translation: CAA14538.1.
PIRC71715.
RefSeqNP_220461.1. NC_000963.1.

3D structure databases

ProteinModelPortalQ9ZE79.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272947.RP067.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAA14538; CAA14538; CAA14538.
GeneID883632.
KEGGrpr:RP067.
PATRIC17900868. VBIRicPro72556_0068.

Phylogenomic databases

eggNOGCOG0188.
HOGENOMHOG000076277.
KOK02621.
OMAGCDPQIV.
OrthoDBEOG661H5V.

Family and domain databases

Gene3D3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPMF_00936. ParC_type1.
InterProIPR024946. Arg_repress_C-like.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
IPR005742. TopoIV_A_Gneg.
[Graphical view]
PfamPF03989. DNA_gyraseA_C. 3 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. SSF56719. 1 hit.
ProtoNetSearch...

Entry information

Entry namePARC_RICPR
AccessionPrimary (citable) accession number: Q9ZE79
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names