Q9ZE79 (PARC_RICPR) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 82.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: DNA topoisomerase 4 subunit A EC=5.99.1.3 Alternative name(s): Topoisomerase IV subunit A | ||||
| Gene names |
| ||||
| Organism | Rickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP] | ||||
| Taxonomic identifier | 272947 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group › ![]() |
Protein attributes
| Sequence length | 738 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule By similarity. HAMAP-Rule MF_00936 |
| Catalytic activity | ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP-Rule MF_00936 |
| Subunit structure | Heterotetramer composed of ParC and ParE By similarity. |
| Subcellular location | Cell membrane; Peripheral membrane protein By similarity HAMAP-Rule MF_00936. |
| Sequence similarities | Belongs to the topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane |
| Ligand | DNA-binding |
| Molecular function | Isomerase Topoisomerase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | DNA topological change Inferred from electronic annotation. Source: InterPro |
| Cellular_component | chromosome Inferred from electronic annotation. Source: InterPro plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | ATP binding Inferred from electronic annotation. Source: InterPro DNA topoisomerase type II (ATP-hydrolyzing) activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 738 | 738 | DNA topoisomerase 4 subunit A HAMAP-Rule MF_00936 | PRO_0000145406 | |||||
Sites | |||||||||
| Active site | 120 | 1 | O-(5'-phospho-DNA)-tyrosine intermediate By similarity | ||||||
| Site | 40 | 1 | Interaction with DNA By similarity | ||||||
| Site | 76 | 1 | Interaction with DNA By similarity | ||||||
| Site | 78 | 1 | Interaction with DNA By similarity | ||||||
| Site | 119 | 1 | Transition state stabilizer By similarity | ||||||
Sequences
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References
| [1] | "The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AJ235270 Genomic DNA. Translation: CAA14538.1. |
| PIR | C71715. |
| RefSeq | NP_220461.1. NC_000963.1. |
3D structure databases | |
| ProteinModelPortal | Q9ZE79. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 272947.RP067. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | CAA14538; CAA14538; CAA14538. |
| GeneID | 883632. |
| KEGG | rpr:RP067. |
| PATRIC | 17900868. VBIRicPro72556_0068. |
Phylogenomic databases | |
| eggNOG | COG0188. |
| HOGENOM | HOG000076277. |
| KO | K02621. |
| OMA | KYKDGGL. |
| ProtClustDB | PRK05561. |
Family and domain databases | |
| Gene3D | 3.30.1360.40. 1 hit. 3.90.199.10. 2 hits. |
| HAMAP | MF_00936. ParC_type1. |
| InterPro | IPR024946. Arg_repress_C-like. IPR006691. GyrA/parC_pinwhl. IPR002205. Topo_IIA_A/C. IPR013758. Topo_IIA_A/C_ab. IPR013760. Topo_IIA_like_dom. IPR005742. TopoIV_A_Gneg. [Graphical view] |
| Pfam | PF03989. DNA_gyraseA_C. 3 hits. PF00521. DNA_topoisoIV. 1 hit. [Graphical view] |
| SMART | SM00434. TOP4c. 1 hit. [Graphical view] |
| SUPFAM | SSF56719. Topo_IIA_cen. 1 hit. |
| TIGRFAMs | TIGR01062. parC_Gneg. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | PARC_RICPR | ||||||||
| Accession | Primary (citable) accession number: Q9ZE79 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Rickettsia prowazekii Rickettsia prowazekii (strain Madrid E): entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with
