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Q9ZE79

- PARC_RICPR

UniProt

Q9ZE79 - PARC_RICPR

Protein

DNA topoisomerase 4 subunit A

Gene

parC

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.UniRule annotation

    Catalytic activityi

    ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei40 – 401Interaction with DNAUniRule annotation
    Sitei76 – 761Interaction with DNAUniRule annotation
    Sitei78 – 781Interaction with DNAUniRule annotation
    Sitei119 – 1191Transition state stabilizerUniRule annotation
    Active sitei120 – 1201O-(5'-phospho-DNA)-tyrosine intermediateUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. DNA binding Source: UniProtKB-HAMAP
    3. DNA topoisomerase type II (ATP-hydrolyzing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. chromosome segregation Source: UniProtKB-HAMAP
    2. DNA topological change Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase, Topoisomerase

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA topoisomerase 4 subunit AUniRule annotation (EC:5.99.1.3UniRule annotation)
    Alternative name(s):
    Topoisomerase IV subunit AUniRule annotation
    Gene namesi
    Name:parCUniRule annotation
    Ordered Locus Names:RP067
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

    GO - Cellular componenti

    1. chromosome Source: InterPro
    2. extrinsic component of plasma membrane Source: UniProtKB-HAMAP

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 738738DNA topoisomerase 4 subunit APRO_0000145406Add
    BLAST

    Interactioni

    Subunit structurei

    Heterotetramer composed of ParC and ParE.UniRule annotation

    Protein-protein interaction databases

    STRINGi272947.RP067.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZE79.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0188.
    HOGENOMiHOG000076277.
    KOiK02621.
    OMAiGCDPQIV.
    OrthoDBiEOG661H5V.

    Family and domain databases

    Gene3Di3.30.1360.40. 1 hit.
    3.90.199.10. 2 hits.
    HAMAPiMF_00936. ParC_type1.
    InterProiIPR024946. Arg_repress_C-like.
    IPR006691. GyrA/parC_pinwhl.
    IPR002205. Topo_IIA_A/C.
    IPR013758. Topo_IIA_A/C_ab.
    IPR013760. Topo_IIA_like_dom.
    IPR005742. TopoIV_A_Gneg.
    [Graphical view]
    PfamiPF03989. DNA_gyraseA_C. 3 hits.
    PF00521. DNA_topoisoIV. 1 hit.
    [Graphical view]
    SMARTiSM00434. TOP4c. 1 hit.
    [Graphical view]
    SUPFAMiSSF56719. SSF56719. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9ZE79-1 [UniParc]FASTAAdd to Basket

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    MKEAKIENID FGNALSERYL AYALSTIMSR SLPDVRDGLK PVHRRLLYAM    50
    LQLRLEPNSG YKKCARVVGD VIGKYHPHGD VAVYDTLVRL AQHFSLRYPL 100
    IDGQGNFGSI DGDNAAAMRY TESRMTEICM LLMEDIDKDT VDFRSTYDDS 150
    DLEPVIMPAS FPNLLANGSE GIAVGMATNI PPHNLHELCD ALLYLIDNPQ 200
    AGINDIMNFI KGPDFPTGGI IIDKAEVINA AYTTGRGSFR VRSRWEKEEL 250
    SYGTYQIVVT EIPYQIQKSK LIEQIAILLK DKKIPLISSI RDESTDIIRV 300
    VIEPRDRSCD PQIVMESLFK LTNLESRIQL NMNVIGSNNV PRVMNILEIL 350
    QEFLVHRKNI IIRRSTYLLN KIKQRLEILK VLRIVYLNLD EIIEIIREED 400
    EPKTIIMERF KISAIQVEVI LNTRLRSLQK LEEHAIIDEH SNLQKQQAIL 450
    EKILKNHKEL WQIVKKEIKA VQTKFGLNTI IGARRTSFEE VDLTNQVVDI 500
    TAFITKEPIT IICSKMGWVR SLKGHNTDLS TIKYKEGDTE KFIIEAYTTD 550
    KILIISSKGR FFTLLADNIS KGKGTGGVSI KLLVDIGNND ITNILVYKPN 600
    QLLLLASSIG KGFLVNSNEV IAQTKTGKQI MNIPEGYSCI ACLPVNGDSI 650
    ACIGESRRLL VFNIDEIPEM KKGQGVVLQR FKNAKLLDIK IFNKQDGLSW 700
    NDGTKIQLEK NIVAFLGKRG GFGTFPPIGF PKNNRFSP 738
    Length:738
    Mass (Da):83,348
    Last modified:May 1, 1999 - v1
    Checksum:i166B9B88C76E52A8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235270 Genomic DNA. Translation: CAA14538.1.
    PIRiC71715.
    RefSeqiNP_220461.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA14538; CAA14538; CAA14538.
    GeneIDi883632.
    KEGGirpr:RP067.
    PATRICi17900868. VBIRicPro72556_0068.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235270 Genomic DNA. Translation: CAA14538.1 .
    PIRi C71715.
    RefSeqi NP_220461.1. NC_000963.1.

    3D structure databases

    ProteinModelPortali Q9ZE79.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP067.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA14538 ; CAA14538 ; CAA14538 .
    GeneIDi 883632.
    KEGGi rpr:RP067.
    PATRICi 17900868. VBIRicPro72556_0068.

    Phylogenomic databases

    eggNOGi COG0188.
    HOGENOMi HOG000076277.
    KOi K02621.
    OMAi GCDPQIV.
    OrthoDBi EOG661H5V.

    Family and domain databases

    Gene3Di 3.30.1360.40. 1 hit.
    3.90.199.10. 2 hits.
    HAMAPi MF_00936. ParC_type1.
    InterProi IPR024946. Arg_repress_C-like.
    IPR006691. GyrA/parC_pinwhl.
    IPR002205. Topo_IIA_A/C.
    IPR013758. Topo_IIA_A/C_ab.
    IPR013760. Topo_IIA_like_dom.
    IPR005742. TopoIV_A_Gneg.
    [Graphical view ]
    Pfami PF03989. DNA_gyraseA_C. 3 hits.
    PF00521. DNA_topoisoIV. 1 hit.
    [Graphical view ]
    SMARTi SM00434. TOP4c. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56719. SSF56719. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.

    Entry informationi

    Entry nameiPARC_RICPR
    AccessioniPrimary (citable) accession number: Q9ZE79
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3