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Q9ZE79

- PARC_RICPR

UniProt

Q9ZE79 - PARC_RICPR

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Protein

DNA topoisomerase 4 subunit A

Gene
parC, RP067
Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule By similarity.UniRule annotation

Catalytic activityi

ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei40 – 401Interaction with DNA By similarity
Sitei76 – 761Interaction with DNA By similarity
Sitei78 – 781Interaction with DNA By similarity
Sitei119 – 1191Transition state stabilizer By similarity
Active sitei120 – 1201O-(5'-phospho-DNA)-tyrosine intermediate By similarity

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. DNA binding Source: UniProtKB-HAMAP
  3. DNA topoisomerase type II (ATP-hydrolyzing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. chromosome segregation Source: UniProtKB-HAMAP
  2. DNA topological change Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Topoisomerase

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA topoisomerase 4 subunit A (EC:5.99.1.3)
Alternative name(s):
Topoisomerase IV subunit A
Gene namesi
Name:parC
Ordered Locus Names:RP067
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. chromosome Source: InterPro
  2. extrinsic component of plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 738738DNA topoisomerase 4 subunit AUniRule annotationPRO_0000145406Add
BLAST

Interactioni

Subunit structurei

Heterotetramer composed of ParC and ParE By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi272947.RP067.

Structurei

3D structure databases

ProteinModelPortaliQ9ZE79.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0188.
HOGENOMiHOG000076277.
KOiK02621.
OMAiGCDPQIV.
OrthoDBiEOG661H5V.

Family and domain databases

Gene3Di3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPiMF_00936. ParC_type1.
InterProiIPR024946. Arg_repress_C-like.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
IPR005742. TopoIV_A_Gneg.
[Graphical view]
PfamiPF03989. DNA_gyraseA_C. 3 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTiSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMiSSF56719. SSF56719. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZE79-1 [UniParc]FASTAAdd to Basket

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MKEAKIENID FGNALSERYL AYALSTIMSR SLPDVRDGLK PVHRRLLYAM    50
LQLRLEPNSG YKKCARVVGD VIGKYHPHGD VAVYDTLVRL AQHFSLRYPL 100
IDGQGNFGSI DGDNAAAMRY TESRMTEICM LLMEDIDKDT VDFRSTYDDS 150
DLEPVIMPAS FPNLLANGSE GIAVGMATNI PPHNLHELCD ALLYLIDNPQ 200
AGINDIMNFI KGPDFPTGGI IIDKAEVINA AYTTGRGSFR VRSRWEKEEL 250
SYGTYQIVVT EIPYQIQKSK LIEQIAILLK DKKIPLISSI RDESTDIIRV 300
VIEPRDRSCD PQIVMESLFK LTNLESRIQL NMNVIGSNNV PRVMNILEIL 350
QEFLVHRKNI IIRRSTYLLN KIKQRLEILK VLRIVYLNLD EIIEIIREED 400
EPKTIIMERF KISAIQVEVI LNTRLRSLQK LEEHAIIDEH SNLQKQQAIL 450
EKILKNHKEL WQIVKKEIKA VQTKFGLNTI IGARRTSFEE VDLTNQVVDI 500
TAFITKEPIT IICSKMGWVR SLKGHNTDLS TIKYKEGDTE KFIIEAYTTD 550
KILIISSKGR FFTLLADNIS KGKGTGGVSI KLLVDIGNND ITNILVYKPN 600
QLLLLASSIG KGFLVNSNEV IAQTKTGKQI MNIPEGYSCI ACLPVNGDSI 650
ACIGESRRLL VFNIDEIPEM KKGQGVVLQR FKNAKLLDIK IFNKQDGLSW 700
NDGTKIQLEK NIVAFLGKRG GFGTFPPIGF PKNNRFSP 738
Length:738
Mass (Da):83,348
Last modified:May 1, 1999 - v1
Checksum:i166B9B88C76E52A8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235270 Genomic DNA. Translation: CAA14538.1.
PIRiC71715.
RefSeqiNP_220461.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA14538; CAA14538; CAA14538.
GeneIDi883632.
KEGGirpr:RP067.
PATRICi17900868. VBIRicPro72556_0068.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235270 Genomic DNA. Translation: CAA14538.1 .
PIRi C71715.
RefSeqi NP_220461.1. NC_000963.1.

3D structure databases

ProteinModelPortali Q9ZE79.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272947.RP067.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAA14538 ; CAA14538 ; CAA14538 .
GeneIDi 883632.
KEGGi rpr:RP067.
PATRICi 17900868. VBIRicPro72556_0068.

Phylogenomic databases

eggNOGi COG0188.
HOGENOMi HOG000076277.
KOi K02621.
OMAi GCDPQIV.
OrthoDBi EOG661H5V.

Family and domain databases

Gene3Di 3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPi MF_00936. ParC_type1.
InterProi IPR024946. Arg_repress_C-like.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
IPR005742. TopoIV_A_Gneg.
[Graphical view ]
Pfami PF03989. DNA_gyraseA_C. 3 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view ]
SMARTi SM00434. TOP4c. 1 hit.
[Graphical view ]
SUPFAMi SSF56719. SSF56719. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiPARC_RICPR
AccessioniPrimary (citable) accession number: Q9ZE79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi