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Protein

DNA topoisomerase 4 subunit A

Gene

parC

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.UniRule annotation

Catalytic activityi

ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei119Transition state stabilizerUniRule annotation1
Active sitei120O-(5'-phospho-DNA)-tyrosine intermediateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Isomerase, Topoisomerase

Enzyme and pathway databases

BioCyciRPRO272947:G1GT0-68-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA topoisomerase 4 subunit AUniRule annotation (EC:5.99.1.3UniRule annotation)
Alternative name(s):
Topoisomerase IV subunit AUniRule annotation
Gene namesi
Name:parCUniRule annotation
Ordered Locus Names:RP067
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000002480 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001454061 – 738DNA topoisomerase 4 subunit AAdd BLAST738

Proteomic databases

PRIDEiQ9ZE79

Interactioni

Subunit structurei

Heterotetramer composed of ParC and ParE.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei40Interaction with DNAUniRule annotation1
Sitei76Interaction with DNAUniRule annotation1
Sitei78Interaction with DNAUniRule annotation1

Protein-protein interaction databases

STRINGi272947.RP067

Structurei

3D structure databases

ProteinModelPortaliQ9ZE79
SMRiQ9ZE79
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C24 Bacteria
COG0188 LUCA
HOGENOMiHOG000076277
KOiK02621
OMAiPRSNRID

Family and domain databases

Gene3Di1.10.268.10, 1 hit
2.120.10.90, 1 hit
3.90.199.10, 3 hits
HAMAPiMF_00936 ParC_type1, 1 hit
InterProiView protein in InterPro
IPR006691 GyrA/parC_rep
IPR035516 Gyrase/topoIV_suA_C
IPR013760 Topo_IIA-like_dom_sf
IPR002205 Topo_IIA_A/C
IPR013758 Topo_IIA_A/C_ab
IPR013757 Topo_IIA_A_a_sf
IPR005742 TopoIV_A_Gneg
PfamiView protein in Pfam
PF03989 DNA_gyraseA_C, 3 hits
PF00521 DNA_topoisoIV, 1 hit
SMARTiView protein in SMART
SM00434 TOP4c, 1 hit
SUPFAMiSSF101904 SSF101904, 1 hit
SSF56719 SSF56719, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ZE79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEAKIENID FGNALSERYL AYALSTIMSR SLPDVRDGLK PVHRRLLYAM
60 70 80 90 100
LQLRLEPNSG YKKCARVVGD VIGKYHPHGD VAVYDTLVRL AQHFSLRYPL
110 120 130 140 150
IDGQGNFGSI DGDNAAAMRY TESRMTEICM LLMEDIDKDT VDFRSTYDDS
160 170 180 190 200
DLEPVIMPAS FPNLLANGSE GIAVGMATNI PPHNLHELCD ALLYLIDNPQ
210 220 230 240 250
AGINDIMNFI KGPDFPTGGI IIDKAEVINA AYTTGRGSFR VRSRWEKEEL
260 270 280 290 300
SYGTYQIVVT EIPYQIQKSK LIEQIAILLK DKKIPLISSI RDESTDIIRV
310 320 330 340 350
VIEPRDRSCD PQIVMESLFK LTNLESRIQL NMNVIGSNNV PRVMNILEIL
360 370 380 390 400
QEFLVHRKNI IIRRSTYLLN KIKQRLEILK VLRIVYLNLD EIIEIIREED
410 420 430 440 450
EPKTIIMERF KISAIQVEVI LNTRLRSLQK LEEHAIIDEH SNLQKQQAIL
460 470 480 490 500
EKILKNHKEL WQIVKKEIKA VQTKFGLNTI IGARRTSFEE VDLTNQVVDI
510 520 530 540 550
TAFITKEPIT IICSKMGWVR SLKGHNTDLS TIKYKEGDTE KFIIEAYTTD
560 570 580 590 600
KILIISSKGR FFTLLADNIS KGKGTGGVSI KLLVDIGNND ITNILVYKPN
610 620 630 640 650
QLLLLASSIG KGFLVNSNEV IAQTKTGKQI MNIPEGYSCI ACLPVNGDSI
660 670 680 690 700
ACIGESRRLL VFNIDEIPEM KKGQGVVLQR FKNAKLLDIK IFNKQDGLSW
710 720 730
NDGTKIQLEK NIVAFLGKRG GFGTFPPIGF PKNNRFSP
Length:738
Mass (Da):83,348
Last modified:May 1, 1999 - v1
Checksum:i166B9B88C76E52A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235270 Genomic DNA Translation: CAA14538.1
PIRiC71715
RefSeqiNP_220461.1, NC_000963.1
WP_004599725.1, NC_000963.1

Genome annotation databases

EnsemblBacteriaiCAA14538; CAA14538; CAA14538
GeneIDi883632
KEGGirpr:RP067
PATRICifig|272947.5.peg.68

Similar proteinsi

Entry informationi

Entry nameiPARC_RICPR
AccessioniPrimary (citable) accession number: Q9ZE79
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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