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Protein

DNA topoisomerase 4 subunit A

Gene

parC

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.UniRule annotation

Catalytic activityi

ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei40 – 401Interaction with DNAUniRule annotation
Sitei76 – 761Interaction with DNAUniRule annotation
Sitei78 – 781Interaction with DNAUniRule annotation
Sitei119 – 1191Transition state stabilizerUniRule annotation
Active sitei120 – 1201O-(5'-phospho-DNA)-tyrosine intermediateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Topoisomerase

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA topoisomerase 4 subunit AUniRule annotation (EC:5.99.1.3UniRule annotation)
Alternative name(s):
Topoisomerase IV subunit AUniRule annotation
Gene namesi
Name:parCUniRule annotation
Ordered Locus Names:RP067
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 738738DNA topoisomerase 4 subunit APRO_0000145406Add
BLAST

Interactioni

Subunit structurei

Heterotetramer composed of ParC and ParE.UniRule annotation

Protein-protein interaction databases

STRINGi272947.RP067.

Structurei

3D structure databases

ProteinModelPortaliQ9ZE79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0188.
HOGENOMiHOG000076277.
KOiK02621.
OMAiGCDPQIV.
OrthoDBiEOG661H5V.

Family and domain databases

Gene3Di3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPiMF_00936. ParC_type1.
InterProiIPR024946. Arg_repress_C-like.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
IPR005742. TopoIV_A_Gneg.
[Graphical view]
PfamiPF03989. DNA_gyraseA_C. 3 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTiSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMiSSF56719. SSF56719. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZE79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEAKIENID FGNALSERYL AYALSTIMSR SLPDVRDGLK PVHRRLLYAM
60 70 80 90 100
LQLRLEPNSG YKKCARVVGD VIGKYHPHGD VAVYDTLVRL AQHFSLRYPL
110 120 130 140 150
IDGQGNFGSI DGDNAAAMRY TESRMTEICM LLMEDIDKDT VDFRSTYDDS
160 170 180 190 200
DLEPVIMPAS FPNLLANGSE GIAVGMATNI PPHNLHELCD ALLYLIDNPQ
210 220 230 240 250
AGINDIMNFI KGPDFPTGGI IIDKAEVINA AYTTGRGSFR VRSRWEKEEL
260 270 280 290 300
SYGTYQIVVT EIPYQIQKSK LIEQIAILLK DKKIPLISSI RDESTDIIRV
310 320 330 340 350
VIEPRDRSCD PQIVMESLFK LTNLESRIQL NMNVIGSNNV PRVMNILEIL
360 370 380 390 400
QEFLVHRKNI IIRRSTYLLN KIKQRLEILK VLRIVYLNLD EIIEIIREED
410 420 430 440 450
EPKTIIMERF KISAIQVEVI LNTRLRSLQK LEEHAIIDEH SNLQKQQAIL
460 470 480 490 500
EKILKNHKEL WQIVKKEIKA VQTKFGLNTI IGARRTSFEE VDLTNQVVDI
510 520 530 540 550
TAFITKEPIT IICSKMGWVR SLKGHNTDLS TIKYKEGDTE KFIIEAYTTD
560 570 580 590 600
KILIISSKGR FFTLLADNIS KGKGTGGVSI KLLVDIGNND ITNILVYKPN
610 620 630 640 650
QLLLLASSIG KGFLVNSNEV IAQTKTGKQI MNIPEGYSCI ACLPVNGDSI
660 670 680 690 700
ACIGESRRLL VFNIDEIPEM KKGQGVVLQR FKNAKLLDIK IFNKQDGLSW
710 720 730
NDGTKIQLEK NIVAFLGKRG GFGTFPPIGF PKNNRFSP
Length:738
Mass (Da):83,348
Last modified:May 1, 1999 - v1
Checksum:i166B9B88C76E52A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235270 Genomic DNA. Translation: CAA14538.1.
PIRiC71715.
RefSeqiNP_220461.1. NC_000963.1.
WP_004599725.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA14538; CAA14538; CAA14538.
GeneIDi883632.
KEGGirpr:RP067.
PATRICi17900868. VBIRicPro72556_0068.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235270 Genomic DNA. Translation: CAA14538.1.
PIRiC71715.
RefSeqiNP_220461.1. NC_000963.1.
WP_004599725.1. NC_000963.1.

3D structure databases

ProteinModelPortaliQ9ZE79.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272947.RP067.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAA14538; CAA14538; CAA14538.
GeneIDi883632.
KEGGirpr:RP067.
PATRICi17900868. VBIRicPro72556_0068.

Phylogenomic databases

eggNOGiCOG0188.
HOGENOMiHOG000076277.
KOiK02621.
OMAiGCDPQIV.
OrthoDBiEOG661H5V.

Family and domain databases

Gene3Di3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPiMF_00936. ParC_type1.
InterProiIPR024946. Arg_repress_C-like.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
IPR005742. TopoIV_A_Gneg.
[Graphical view]
PfamiPF03989. DNA_gyraseA_C. 3 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTiSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMiSSF56719. SSF56719. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiPARC_RICPR
AccessioniPrimary (citable) accession number: Q9ZE79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 27, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.