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Reviewed, UniProtKB/Swiss-Prot Q9ZE70 (SAM_RICPR)

Last modified December 15, 2009. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    S-adenosylmethionine uptake transporter
Gene names
Name: sam
Ordered Locus Names: RP076
OrganismRickettsia prowazekii [Complete proteome] [HAMAP]
Taxonomic identifier782 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

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Protein attributes

Sequence length294 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Transports S-adenosylmethionine.

Enzyme regulation

Transport is inhibited by S-adenosylethionine and to a lesser extent by S-adenosylhomocysteine. Unlike eukaryotic transporters is not inhibited by sinfungin. Also inhibited by 2.4-dinitrophenol, suggesting transport is an energy-dependent process.

Subcellular location

Cell inner membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the drug/metabolite transporter (DMT) superfamily. 10 TMS drug/metabolite exporter (TC 2.A.7.3) family. [View classification]

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Ontologies

Keywords
   Biological processAmino-acid transport
Transport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processamino acid transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 294294S-adenosylmethionine uptake transporter
PRO_0000280997

Regions

Transmembrane4 – 2421 Potential
Transmembrane41 – 6121 Potential
Transmembrane74 – 9118 Potential
Transmembrane98 – 11821 Potential
Transmembrane121 – 14121 Potential
Transmembrane148 – 16821 Potential
Transmembrane178 – 19821 Potential
Transmembrane207 – 22721 Potential
Transmembrane237 – 25721 Potential
Transmembrane260 – 28021 Potential

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Sequences

Sequence LengthMass (Da)Tools
Q9ZE70-1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 3DE6527258466AB1

FASTA29433,092
        10         20         30         40         50         60 
MNDALKTYLN GICWFLLSLV TSSINDVMSK YLGTRLHSFE VAFFRFFFSS IVLLPFVVYY 

        70         80         90        100        110        120 
GKNALKTSRP FVHVLRGLLL FFGMTSWTYG LTIAPVTTAT VVSFAIPLFT LILAVFILNE 

       130        140        150        160        170        180 
NIIWQRWVVT VVGFIGLVVM LKPHTKDFNP EILYLILAAI SFAMLDIINK KFVVKESMLS 

       190        200        210        220        230        240 
MLFYSAIVTA MVSLPVAMQY WITPSSFELA LLFVLGSSGS FILFFLLKAF SIVDATATAP 

       250        260        270        280        290 
YRYLELVISA IAAYFIFNEF PDKSTVHGAV IIIPATLFII YSEKKSMSSK HESQ

« Hide

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References

« Hide 'large scale' references
[1]"S-adenosylmethionine transport in Rickettsia prowazekii."
Tucker A.M., Winkler H.H., Driskell L.O., Wood D.O.
J. Bacteriol. 185:3031-3035(2003) [PubMed: 12730161] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
Strain: Madrid E.
[2]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed: 9823893] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.

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Cross-references

Sequence databases

AJ235270 Genomic DNA. Translation: CAA14547.1.
PIRD71716.
RefSeqNP_220470.1.

3D structure databases

ModBaseSearch...

Protein family/group databases

TCDB2.A.7.3.7. drug/metabolite transporter (DMT) superfamily.

Genome annotation databases

GeneID883647.
GenomeReviewsGene locus RP076 in contig AJ235269_GR.
KEGGrpr:RP076.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG559298.
OMAPVASQYW.

Enzyme and pathway databases

BioCycRPRO272947:RP076-MON.

Family and domain databases

InterProIPR000620. DUF6_TM.
[Graphical view]
PfamPF00892. DUF6. 2 hits.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameSAM_RICPR
AccessionPrimary (citable) accession number: Q9ZE70
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 1, 1999
Last modified: December 15, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents