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Q9ZE58

- KDTA_RICPR

UniProt

Q9ZE58 - KDTA_RICPR

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Protein

3-deoxy-D-manno-octulosonic acid transferase

Gene
waaA, kdtA, RP089
Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A By similarity.

Catalytic activityi

Lipid IV(A) + CMP-alpha-Kdo = alpha-Kdo-(2->6)-lipid IV(A) + CMP.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei102 – 1021Proton acceptor By similarity
Sitei172 – 1721Transition state stabilizer By similarity
Sitei247 – 2471Transition state stabilizer By similarity

GO - Molecular functioni

  1. transferase activity Source: UniProtKB-KW

GO - Biological processi

  1. lipopolysaccharide core region biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00958.

Protein family/group databases

CAZyiGT30. Glycosyltransferase Family 30.

Names & Taxonomyi

Protein namesi
Recommended name:
3-deoxy-D-manno-octulosonic acid transferase (EC:2.4.99.12)
Short name:
Kdo transferase
Alternative name(s):
Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase
Gene namesi
Name:waaA
Synonyms:kdtA
Ordered Locus Names:RP089
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2221Helical; Signal-anchor; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4614613-deoxy-D-manno-octulosonic acid transferasePRO_0000080290Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272947.RP089.

Structurei

3D structure databases

ProteinModelPortaliQ9ZE58.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 8842RPE1 insertAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni306 – 3072CMP-Kdo binding By similarity
Regioni347 – 3493CMP-Kdo binding By similarity
Regioni372 – 3754CMP-Kdo binding By similarity

Sequence similaritiesi

Contains 1 RPE1 insert domain.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1519.
HOGENOMiHOG000010628.
KOiK02527.
OMAiLPYDLPC.
OrthoDBiEOG6H7FNN.

Family and domain databases

InterProiIPR007507. Glycos_transf_N.
[Graphical view]
PfamiPF04413. Glycos_transf_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZE58-1 [UniParc]FASTAAdd to Basket

« Hide

MMLLYYTLSF ILLPVYFIII FIRLLIGKED IRRIQERFAI GKQRQNSALD    50
FIQMSVNKEG FTDHKTTSYV DMHRNASLMY KLSLERSYAH SLVWIHAASV 100
GEVMTALTLI HNISKLAPNV RFLITSWTNA SAKILSTKLP KIATHQFLPI 150
DNVIFTRKFL RNWQPDLGIF IESELWPCTI NEGAKYCKLL LINARISNKS 200
FKAWLKRKRF FQLIIKNFSK IIVQSERDLQ KFNALGISDA MNLGNIKFAN 250
EKLLVNQEKL SKLILHLDNR RVLVFASTHP EDEEVILPII NNLKEQFIDC 300
YIILIPRHPE RIKSIINNCK LHHLSATAKS QNDLPVLNND LYIVDRFGEM 350
GLFFSVATIS FIGGSFKQGG HNILEAAYFS NCIIFGPDMS KNTDIAKGIL 400
QNNAAIQIKN GKDLLNTLTS LLNANNALKL KTYRENALKF VENNQKKILD 450
EYLQIIKQFL P 461
Length:461
Mass (Da):52,976
Last modified:May 1, 1999 - v1
Checksum:iBE027A7C2D34AC28
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235270 Genomic DNA. Translation: CAA14559.1.
PIRiH71717.
RefSeqiNP_220482.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA14559; CAA14559; CAA14559.
GeneIDi883675.
KEGGirpr:RP089.
PATRICi17900912. VBIRicPro72556_0089.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235270 Genomic DNA. Translation: CAA14559.1 .
PIRi H71717.
RefSeqi NP_220482.1. NC_000963.1.

3D structure databases

ProteinModelPortali Q9ZE58.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272947.RP089.

Protein family/group databases

CAZyi GT30. Glycosyltransferase Family 30.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAA14559 ; CAA14559 ; CAA14559 .
GeneIDi 883675.
KEGGi rpr:RP089.
PATRICi 17900912. VBIRicPro72556_0089.

Phylogenomic databases

eggNOGi COG1519.
HOGENOMi HOG000010628.
KOi K02527.
OMAi LPYDLPC.
OrthoDBi EOG6H7FNN.

Enzyme and pathway databases

UniPathwayi UPA00958 .

Family and domain databases

InterProi IPR007507. Glycos_transf_N.
[Graphical view ]
Pfami PF04413. Glycos_transf_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.
  2. Cited for: DOMAIN RPE1.

Entry informationi

Entry nameiKDTA_RICPR
AccessioniPrimary (citable) accession number: Q9ZE58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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