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Q9ZE58

- KDTA_RICPR

UniProt

Q9ZE58 - KDTA_RICPR

Protein

3-deoxy-D-manno-octulosonic acid transferase

Gene

waaA

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A By similarity.By similarity

    Catalytic activityi

    Lipid IV(A) + CMP-alpha-Kdo = alpha-Kdo-(2->6)-lipid IV(A) + CMP.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei102 – 1021Proton acceptorBy similarity
    Sitei172 – 1721Transition state stabilizerBy similarity
    Sitei247 – 2471Transition state stabilizerBy similarity

    GO - Molecular functioni

    1. transferase activity Source: UniProtKB-KW

    GO - Biological processi

    1. lipopolysaccharide core region biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Lipopolysaccharide biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00958.

    Protein family/group databases

    CAZyiGT30. Glycosyltransferase Family 30.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-deoxy-D-manno-octulosonic acid transferase (EC:2.4.99.12)
    Short name:
    Kdo transferase
    Alternative name(s):
    Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase
    Gene namesi
    Name:waaA
    Synonyms:kdtA
    Ordered Locus Names:RP089
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    Subcellular locationi

    Cell inner membrane By similarity; Single-pass membrane protein By similarity; Cytoplasmic side By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4614613-deoxy-D-manno-octulosonic acid transferasePRO_0000080290Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272947.RP089.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZE58.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei2 – 2221Helical; Signal-anchorSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini47 – 8842RPE1 insertAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni306 – 3072CMP-Kdo bindingBy similarity
    Regioni347 – 3493CMP-Kdo bindingBy similarity
    Regioni372 – 3754CMP-Kdo bindingBy similarity

    Sequence similaritiesi

    Contains 1 RPE1 insert domain.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1519.
    HOGENOMiHOG000010628.
    KOiK02527.
    OMAiLPYDLPC.
    OrthoDBiEOG6H7FNN.

    Family and domain databases

    InterProiIPR007507. Glycos_transf_N.
    [Graphical view]
    PfamiPF04413. Glycos_transf_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZE58-1 [UniParc]FASTAAdd to Basket

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    MMLLYYTLSF ILLPVYFIII FIRLLIGKED IRRIQERFAI GKQRQNSALD    50
    FIQMSVNKEG FTDHKTTSYV DMHRNASLMY KLSLERSYAH SLVWIHAASV 100
    GEVMTALTLI HNISKLAPNV RFLITSWTNA SAKILSTKLP KIATHQFLPI 150
    DNVIFTRKFL RNWQPDLGIF IESELWPCTI NEGAKYCKLL LINARISNKS 200
    FKAWLKRKRF FQLIIKNFSK IIVQSERDLQ KFNALGISDA MNLGNIKFAN 250
    EKLLVNQEKL SKLILHLDNR RVLVFASTHP EDEEVILPII NNLKEQFIDC 300
    YIILIPRHPE RIKSIINNCK LHHLSATAKS QNDLPVLNND LYIVDRFGEM 350
    GLFFSVATIS FIGGSFKQGG HNILEAAYFS NCIIFGPDMS KNTDIAKGIL 400
    QNNAAIQIKN GKDLLNTLTS LLNANNALKL KTYRENALKF VENNQKKILD 450
    EYLQIIKQFL P 461
    Length:461
    Mass (Da):52,976
    Last modified:May 1, 1999 - v1
    Checksum:iBE027A7C2D34AC28
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235270 Genomic DNA. Translation: CAA14559.1.
    PIRiH71717.
    RefSeqiNP_220482.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA14559; CAA14559; CAA14559.
    GeneIDi883675.
    KEGGirpr:RP089.
    PATRICi17900912. VBIRicPro72556_0089.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235270 Genomic DNA. Translation: CAA14559.1 .
    PIRi H71717.
    RefSeqi NP_220482.1. NC_000963.1.

    3D structure databases

    ProteinModelPortali Q9ZE58.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP089.

    Protein family/group databases

    CAZyi GT30. Glycosyltransferase Family 30.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA14559 ; CAA14559 ; CAA14559 .
    GeneIDi 883675.
    KEGGi rpr:RP089.
    PATRICi 17900912. VBIRicPro72556_0089.

    Phylogenomic databases

    eggNOGi COG1519.
    HOGENOMi HOG000010628.
    KOi K02527.
    OMAi LPYDLPC.
    OrthoDBi EOG6H7FNN.

    Enzyme and pathway databases

    UniPathwayi UPA00958 .

    Family and domain databases

    InterProi IPR007507. Glycos_transf_N.
    [Graphical view ]
    Pfami PF04413. Glycos_transf_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.
    2. Cited for: DOMAIN RPE1.

    Entry informationi

    Entry nameiKDTA_RICPR
    AccessioniPrimary (citable) accession number: Q9ZE58
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3