Q9ZE52 (ALR_RICPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alanine racemase
EC=5.1.1.1

Gene names

Name:	alr
Ordered Locus Names:	RP095

Organism

Rickettsia prowazekii (strain Madrid E)

Taxonomic identifier

272947 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	404 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Provides the D-alanine required for cell wall biosynthesis By similarity. HAMAP MF_01201
Catalytic activity	L-alanine = D-alanine. HAMAP MF_01201
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01201
Pathway	Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP MF_01201 Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_01201
Sequence similarities	Belongs to the alanine racemase family. Contains 1 RPE1 insert domain.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	alanine metabolic process Inferred from electronic annotation. Source: InterPro cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alanine racemase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 404	404	Alanine racemase HAMAP MF_01201		PRO_0000114557
Regions
	Domain	226 – 273	48	RPE1 insert
Sites
	Active site	34	1	Proton acceptor; specific for D-alanine By similarity
	Active site	298	1	Proton acceptor; specific for L-alanine By similarity
Amino acid modifications
	Modified residue	34	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ZE52 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: FEA23D86698256DA	FASTA	404	44,730
	10 20 30 40 50 60 MSLCTLEINL SAIKNNYRLL QDICKTALVG AVVKANGYGL GAMQIAKALI KENCQYFFVA 70 80 90 100 110 120 TSEEGINLRK VLNNDITILV LNGVFTHDAL ELIQYNLTPV LNNLSQIEIW QKFSNLKGKI 130 140 150 160 170 180 LPCYLHFNTG LNRFGLNSDE IEQLINDRDL LKGLDLQYII SHLAASEETG NPYNLIQLNR 190 200 210 220 230 240 FKVYLEYFPN VKASFANSGG IFLGQDYHFD LARPGAALYG LNSLIEVSSN LSYTEEFESN 250 260 270 280 290 300 TAALTTTACI NKCPDVSVRL TPKLPLKGSY TVRLQNPVTL KAPIIDLQNL TLDSHIGYNM 310 320 330 340 350 360 TFTTKRDSVI ATLPLGYADG FSRNFSSQGE VFINSCSVPI VGRVSMDLIN IDVTDLPPSE 370 380 390 400 VFLGQEAEII GNYCTPDKIA SIIGTIGYEV LTSLGSRYKR KYIS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed: 9823893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.
[2]	"Selfish DNA in protein-coding genes of Rickettsia." Ogata H., Audic S., Barbe V., Artiguenave F., Fournier P.-E., Raoult D., Claverie J.-M. Science 290:347-350(2000) [PubMed: 11030655] [Abstract] Cited for: DOMAIN RPE1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ235270 Genomic DNA. Translation: CAA14565.1.
PIR	F71718.
RefSeq	NP_220488.1. NC_000963.1.
3D structure databases
ProteinModelPortal	Q9ZE52.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	883682.
GenomeReviews	Gene locus RP095 in contig AJ235269_GR.
KEGG	rpr:RP095.
PATRIC	17900924. VBIRicPro72556_0095.
Phylogenomic databases
HOGENOM	HBG712172.
OMA	YCTPDKI.
ProtClustDB	PRK00053.
Enzyme and pathway databases
BioCyc	RPRO272947:RP095-MONOMER.
Family and domain databases
HAMAP	MF_01201. Ala_racemase. Divergent sequence. [Tree]
InterPro	IPR000821. Ala_racemase. IPR009006. Ala_racemase/Decarboxylase_C. IPR011079. Ala_racemase_C. IPR001608. Ala_racemase_N. IPR020622. Ala_racemase_pyridoxalP-BS. IPR005728. Rickett_RPE. [Graphical view]
Gene3D	G3DSA:2.40.37.10. Ala_racemase/Decarboxylase_C. 2 hits.
KO	K01775.
Pfam	PF00842. Ala_racemase_C. 1 hit. PF01168. Ala_racemase_N. 1 hit. [Graphical view]
PRINTS	PR00992. ALARACEMASE.
SMART	SM01005. Ala_racemase_C. 1 hit. [Graphical view]
SUPFAM	SSF50621. Racem_decarbox_C. 1 hit.
TIGRFAMs	TIGR01045. RPE1. 1 hit.
PROSITE	PS00395. ALANINE_RACEMASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALR_RICPR

Accession

Primary (citable) accession number: Q9ZE52

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program