Q9ZE38 (ACKA_RICPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetate kinase
EC=2.7.2.1

Alternative name(s):
Acetokinase

Gene names

Name:	ackA
Ordered Locus Names:	RP110

Organism

Rickettsia prowazekii (strain Madrid E)

Taxonomic identifier

272947 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	385 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm By similarity HAMAP MF_00020.
Sequence similarities	Belongs to the acetokinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 385	385	Acetate kinase HAMAP MF_00020		PRO_0000107605

Sequences

	Sequence		Length	Mass (Da)
	Q9ZE38 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: C683723AF67BF0FD	FASTA	385	43,361
	10 20 30 40 50 60 MKDVILIANA GSSSLKISIF AIQNKRVNDK IYNIFLEKNN NKILFYINQQ KESTTSIKDD 70 80 90 100 110 120 PIEMMINLFE EWWKKQSALN LIATGHRIVH GGKNFNKPVV VNKKVIKELR VLIPLSPLHQ 130 140 150 160 170 180 PYNLQVLDLF FQKYKAISHI ICFDTSFHCT NSPITKAFGL PKQYYDKGIM RYGFHGLSYQ 190 200 210 220 230 240 YVSSHFKEIT MEDLPPKAII AHLGSGSSLC AIKNGLSLTS SMGFSVLDGV MMATRPGNLD 250 260 270 280 290 300 PGVVLYLINN EKMTINEITE LLYKKSGLLG MSGESSDMRT LIASNSHDSK FAVDLFVYRI 310 320 330 340 350 360 VLEIGKLIAA LEGIDCLIFT AGVGQNSPVI REMISKKLSW LGIKIDYEKN QKNEHRISTK 370 380 GSKIKVFVVP TNEELIIAEE VMKFL

References

[1]	"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed: 9823893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ235270 Genomic DNA. Translation: CAA14579.1.
PIR	D71720.
RefSeq	NP_220502.1. NC_000963.1.
3D structure databases
ProteinModelPortal	Q9ZE38.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	883724.
GenomeReviews	Gene locus RP110 in contig AJ235269_GR.
KEGG	rpr:RP110.
PATRIC	17900960. VBIRicPro72556_0112.
Phylogenomic databases
HOGENOM	HBG285863.
OMA	SAVIREM.
ProtClustDB	CLSK870749.
Enzyme and pathway databases
BioCyc	RPRO272947:RP110-MONOMER.
Family and domain databases
HAMAP	MF_00020. Acetate_kinase. [Tree]
InterPro	IPR004372. Ac/Proprionate_kinase. IPR000890. Aliphatic_acid_kin_short-chain. IPR023865. Aliphatic_acid_kinase_CS. [Graphical view]
KO	K00925.
PANTHER	PTHR21060. Acetate_kin. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. AckA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACKA_RICPR

Accession

Primary (citable) accession number: Q9ZE38

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program