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Q9ZE33 (NUOF_RICPR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
NADH-quinone oxidoreductase subunit F

EC=1.6.99.5
Alternative name(s):
NADH dehydrogenase I subunit F
NDH-1 subunit F
Gene names
Name:nuoF
Ordered Locus Names:RP115
OrganismRickettsia prowazekii (strain Madrid E)
Taxonomic identifier272947 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length421 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.

Catalytic activity

NADH + quinone = NAD+ + quinol.

Cofactor

Binds 1 FMN Potential.

Binds 1 4Fe-4S cluster Potential.

Sequence similarities

Belongs to the complex I 51 kDa subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 421421NADH-quinone oxidoreductase subunit F
PRO_0000118580

Regions

Nucleotide binding54 – 6310NAD By similarity
Nucleotide binding166 – 21348FMN By similarity

Sites

Metal binding3441Iron-sulfur (4Fe-4S) Potential
Metal binding3471Iron-sulfur (4Fe-4S) Potential
Metal binding3501Iron-sulfur (4Fe-4S) Potential
Metal binding3901Iron-sulfur (4Fe-4S) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9ZE33 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 67BF420E31638A63

FASTA42146,291
        10         20         30         40         50         60 
MLKEEDKIFT NLYGQQSYDL KSSQKRGDWY NTKALIDKGR DFIIDEVKKS GLRGRGGAGF 

        70         80         90        100        110        120 
STGMKWSFMP KNSEKPCYLV VNADESEPGT CKDRDILRFE PHKLIEGCLI ASFAIGANTC 

       130        140        150        160        170        180 
YIYIRGEFYN EASNMQRALD EAYKEGLIGK NACGSGFDCN IYLHRGAGAY ICGEETALLE 

       190        200        210        220        230        240 
SLEGKKGMPR LKPPFPAGFG LYGCPTTINN VESIAVVPTI LRRGASWFAA IGKPNNTGTK 

       250        260        270        280        290        300 
VFCISGHVNK PCNIEEVMGV PLKELIEKYA GGVRGGWNNL KAIIPGGASV PLLPKSLCEV 

       310        320        330        340        350        360 
EMDFDSLRTV GSGLGTGGII VMDKSTDIIY AIARLSKFYM HESCGQCTPC REGTGWMWRV 

       370        380        390        400        410        420 
MMRLVNGNAK KNEIDTLLNV TKEIEGHTIC ALGDAAAWPI QGLIRHFRDE IEQRIKSFGI 


A 

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References

[1]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed: 9823893] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ235270 Genomic DNA. Translation: CAA14584.1.
PIRA71721.
RefSeqNP_220507.1. NC_000963.1.

3D structure databases

ProteinModelPortalQ9ZE33.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID883736.
GenomeReviewsGene locus RP115 in contig AJ235269_GR.
KEGGrpr:RP115.
PATRIC17900970. VBIRicPro72556_0117.

Phylogenomic databases

HOGENOMHBG669338.
OMAKHAGGVT.
ProtClustDBPRK13596.

Enzyme and pathway databases

BioCycRPRO272947:RP115-MONOMER.

Family and domain databases

InterProIPR001949. NADH-UbQ_OxRdtase_51kDa_CS.
IPR019575. NADH-UbQ_OxRdtase_Fsu_4Fe4S-bd.
IPR011537. NADH-UbQ_OxRdtase_suF.
IPR011538. NADH_UbQ_OxRdtase_51kDa_su.
IPR019554. Soluble_ligand-bd.
[Graphical view]
KOK00335.
PfamPF01512. Complex1_51K. 1 hit.
PF10589. NADH_4Fe-4S. 1 hit.
PF10531. SLBB. 1 hit.
[Graphical view]
SMARTSM00928. NADH_4Fe-4S. 1 hit.
[Graphical view]
TIGRFAMsTIGR01959. NuoF_fam. 1 hit.
PROSITEPS00644. COMPLEX1_51K_1. 1 hit.
PS00645. COMPLEX1_51K_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNUOF_RICPR
AccessionPrimary (citable) accession number: Q9ZE33
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: January 25, 2012
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names

SIMILARITY comments

Index of protein domains and families