Q9ZE23 (RL1_RICPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
50S ribosomal protein L1

Gene names

Name:	rplA
Ordered Locus Names:	RP137

Organism

Rickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]

Taxonomic identifier

272947 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group › Rickettsia prowazekii

Protein attributes

Sequence length	238 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release By similarity. HAMAP-Rule MF_01318 Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA By similarity. HAMAP-Rule MF_01318
Subunit structure	Part of the 50S ribosomal subunit By similarity. HAMAP-Rule MF_01318
Sequence similarities	Belongs to the ribosomal protein L1P family.

Ontologies

Keywords
Biological process	Translation regulation
Ligand	RNA-binding rRNA-binding tRNA-binding
Molecular function	Repressor Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of translation Inferred from electronic annotation. Source: UniProtKB-KW translation Inferred from electronic annotation. Source: HAMAP
Cellular_component	large ribosomal subunit Inferred from electronic annotation. Source: InterPro
Molecular_function	rRNA binding Inferred from electronic annotation. Source: HAMAP structural constituent of ribosome Inferred from electronic annotation. Source: InterPro tRNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 238	238	50S ribosomal protein L1 HAMAP-Rule MF_01318		PRO_0000125723

Sequences

	Sequence		Length	Mass (Da)
	Q9ZE23 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 147DCA27E74E9131	FASTA	238	25,487
	10 20 30 40 50 60 MSNKDICVKI SGSKKIREAR EKVKSDTLYN LTNAVAQLKS ASYVKFDPTL EIVMKLGIDP 70 80 90 100 110 120 RHSDQIVRGV VNLPAGTGKT IRVAVICKEE REEEAKSAGA DLVGSINIID EIKAGQINFD 130 140 150 160 170 180 VCIATPDMMS MISSVARILG PKGLMPNPKL GTVTLDIKNA IKNAKSGQVE YRAEKAGIIH 190 200 210 220 230 AGLGKLSFSD QDLLKNLNAF IGAVIKAKPV GLKGNYLKAI YLSSTMGASV QIDLTSIS

References

[1]

"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ235270 Genomic DNA. Translation: CAA14605.1.
PIR	F71723.
RefSeq	NP_220528.1. NC_000963.1.
3D structure databases
ProteinModelPortal	Q9ZE23.
ModBase	Search...
Protein-protein interaction databases
STRING	272947.RP137.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAA14605; CAA14605; CAA14605.
GeneID	883790.
KEGG	rpr:RP137.
PATRIC	17901014. VBIRicPro72556_0138.
Phylogenomic databases
eggNOG	COG0081.
HOGENOM	HOG000207015.
KO	K02863.
OMA	AKGRYVK.
ProtClustDB	PRK05424.
Family and domain databases
Gene3D	3.30.190.20. 2 hits. 3.40.50.790. 1 hit.
HAMAP	MF_01318_B. Ribosomal_L1_B.
InterPro	IPR005878. Ribosom_L1_bac-type. IPR002143. Ribosomal_L1. IPR016094. Ribosomal_L1_2-a/b-sand. IPR016095. Ribosomal_L1_3-a/b-sand. IPR023673. Ribosomal_L1_CS. IPR023674. Ribosomal_L1_SF. [Graphical view]
Pfam	PF00687. Ribosomal_L1. 1 hit. [Graphical view]
PIRSF	PIRSF002155. Ribosomal_L1. 1 hit.
SUPFAM	SSF56808. Ribosomal_L1. 1 hit.
TIGRFAMs	TIGR01169. rplA_bact. 1 hit.
PROSITE	PS01199. RIBOSOMAL_L1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RL1_RICPR

Accession

Primary (citable) accession number: Q9ZE23

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program