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Q9ZE00

- RLME_RICPR

UniProt

Q9ZE00 - RLME_RICPR

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Protein
Ribosomal RNA large subunit methyltransferase E
Gene
rlmE, ftsJ, rrmJ, RP163
Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + uridine(2552) in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methyluridine(2552) in 23S rRNA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei78 – 781S-adenosyl-L-methionine; via amide nitrogen By similarity
Binding sitei80 – 801S-adenosyl-L-methionine; via amide nitrogen By similarity
Binding sitei103 – 1031S-adenosyl-L-methionine By similarity
Binding sitei119 – 1191S-adenosyl-L-methionine By similarity
Binding sitei143 – 1431S-adenosyl-L-methionine By similarity
Active sitei183 – 1831Proton acceptor By similarity

GO - Molecular functioni

  1. rRNA (uridine-2'-O-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase E (EC:2.1.1.166)
Alternative name(s):
23S rRNA Um2552 methyltransferase
rRNA (uridine-2'-O-)-methyltransferase
Gene namesi
Name:rlmE
Synonyms:ftsJ, rrmJ
Ordered Locus Names:RP163
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 227227Ribosomal RNA large subunit methyltransferase EUniRule annotation
PRO_0000155534Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272947.RP163.

Structurei

3D structure databases

ProteinModelPortaliQ9ZE00.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0293.
HOGENOMiHOG000162367.
KOiK02427.
OMAiQYVVSQI.
OrthoDBiEOG657JC0.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01547. RNA_methyltr_E.
InterProiIPR015507. rRNA-MeTfrase_E.
IPR002877. rRNA_MeTrfase_FtsJ_dom.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR10920. PTHR10920. 1 hit.
PfamiPF01728. FtsJ. 1 hit.
[Graphical view]
PIRSFiPIRSF005461. 23S_rRNA_mtase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZE00-1 [UniParc]FASTAAdd to Basket

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MTNNLSGYRN KIVRVKTSKK RPISSSNWLR RQLNDPYVAK ARLEGFRSRA    50
AYKLLEIHYK FRLFTPNMKI VDLGAAPGGW SQVASKLIKA SDNNLNNKII 100
SIDLLEIEPI VGVEFLQKDF FEKDTEELII HNLEGKADIV MSDMASNTIG 150
HKATDHMRTL LLCEQAFEFA LKVLKPSCHF IAKIFRGGAE TALLNKVKRE 200
FRTVKHFKPV SSRSESTEIY LVALNKK 227
Length:227
Mass (Da):25,881
Last modified:May 1, 1999 - v1
Checksum:i3A9CCA205D925118
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235270 Genomic DNA. Translation: CAA14630.1.
PIRiG71726.
RefSeqiNP_220553.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA14630; CAA14630; CAA14630.
GeneIDi883842.
KEGGirpr:RP163.
PATRICi17901074. VBIRicPro72556_0167.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235270 Genomic DNA. Translation: CAA14630.1 .
PIRi G71726.
RefSeqi NP_220553.1. NC_000963.1.

3D structure databases

ProteinModelPortali Q9ZE00.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272947.RP163.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAA14630 ; CAA14630 ; CAA14630 .
GeneIDi 883842.
KEGGi rpr:RP163.
PATRICi 17901074. VBIRicPro72556_0167.

Phylogenomic databases

eggNOGi COG0293.
HOGENOMi HOG000162367.
KOi K02427.
OMAi QYVVSQI.
OrthoDBi EOG657JC0.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01547. RNA_methyltr_E.
InterProi IPR015507. rRNA-MeTfrase_E.
IPR002877. rRNA_MeTrfase_FtsJ_dom.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR10920. PTHR10920. 1 hit.
Pfami PF01728. FtsJ. 1 hit.
[Graphical view ]
PIRSFi PIRSF005461. 23S_rRNA_mtase. 1 hit.
SUPFAMi SSF53335. SSF53335. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiRLME_RICPR
AccessioniPrimary (citable) accession number: Q9ZE00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi