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Q9ZE00

- RLME_RICPR

UniProt

Q9ZE00 - RLME_RICPR

Protein

Ribosomal RNA large subunit methyltransferase E

Gene

rlmE

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    • Comment

    Functioni

    Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + uridine(2552) in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methyluridine(2552) in 23S rRNA.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei78 – 781S-adenosyl-L-methionine; via amide nitrogenUniRule annotation
    Binding sitei80 – 801S-adenosyl-L-methionine; via amide nitrogenUniRule annotation
    Binding sitei103 – 1031S-adenosyl-L-methionineUniRule annotation
    Binding sitei119 – 1191S-adenosyl-L-methionineUniRule annotation
    Binding sitei143 – 1431S-adenosyl-L-methionineUniRule annotation
    Active sitei183 – 1831Proton acceptorUniRule annotation

    GO - Molecular functioni

    1. rRNA (uridine-2'-O-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    rRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosomal RNA large subunit methyltransferase EUniRule annotation (EC:2.1.1.166UniRule annotation)
    Alternative name(s):
    23S rRNA Um2552 methyltransferaseUniRule annotation
    rRNA (uridine-2'-O-)-methyltransferaseUniRule annotation
    Gene namesi
    Name:rlmEUniRule annotation
    Synonyms:ftsJUniRule annotation, rrmJUniRule annotation
    Ordered Locus Names:RP163
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 227227Ribosomal RNA large subunit methyltransferase EPRO_0000155534Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272947.RP163.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZE00.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the methyltransferase superfamily. RlmE family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0293.
    HOGENOMiHOG000162367.
    KOiK02427.
    OMAiQYVVSQI.
    OrthoDBiEOG657JC0.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01547. RNA_methyltr_E.
    InterProiIPR015507. rRNA-MeTfrase_E.
    IPR002877. rRNA_MeTrfase_FtsJ_dom.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PANTHERiPTHR10920. PTHR10920. 1 hit.
    PfamiPF01728. FtsJ. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005461. 23S_rRNA_mtase. 1 hit.
    SUPFAMiSSF53335. SSF53335. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9ZE00-1 [UniParc]FASTAAdd to Basket

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    MTNNLSGYRN KIVRVKTSKK RPISSSNWLR RQLNDPYVAK ARLEGFRSRA    50
    AYKLLEIHYK FRLFTPNMKI VDLGAAPGGW SQVASKLIKA SDNNLNNKII 100
    SIDLLEIEPI VGVEFLQKDF FEKDTEELII HNLEGKADIV MSDMASNTIG 150
    HKATDHMRTL LLCEQAFEFA LKVLKPSCHF IAKIFRGGAE TALLNKVKRE 200
    FRTVKHFKPV SSRSESTEIY LVALNKK 227
    Length:227
    Mass (Da):25,881
    Last modified:May 1, 1999 - v1
    Checksum:i3A9CCA205D925118
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235270 Genomic DNA. Translation: CAA14630.1.
    PIRiG71726.
    RefSeqiNP_220553.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA14630; CAA14630; CAA14630.
    GeneIDi883842.
    KEGGirpr:RP163.
    PATRICi17901074. VBIRicPro72556_0167.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235270 Genomic DNA. Translation: CAA14630.1 .
    PIRi G71726.
    RefSeqi NP_220553.1. NC_000963.1.

    3D structure databases

    ProteinModelPortali Q9ZE00.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP163.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA14630 ; CAA14630 ; CAA14630 .
    GeneIDi 883842.
    KEGGi rpr:RP163.
    PATRICi 17901074. VBIRicPro72556_0167.

    Phylogenomic databases

    eggNOGi COG0293.
    HOGENOMi HOG000162367.
    KOi K02427.
    OMAi QYVVSQI.
    OrthoDBi EOG657JC0.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01547. RNA_methyltr_E.
    InterProi IPR015507. rRNA-MeTfrase_E.
    IPR002877. rRNA_MeTrfase_FtsJ_dom.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PANTHERi PTHR10920. PTHR10920. 1 hit.
    Pfami PF01728. FtsJ. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005461. 23S_rRNA_mtase. 1 hit.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.

    Entry informationi

    Entry nameiRLME_RICPR
    AccessioniPrimary (citable) accession number: Q9ZE00
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3