ID   RSME_RICPR              Reviewed;         198 AA.
AC   Q9ZDZ5;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   27-MAR-2024, entry version 102.
DE   RecName: Full=Ribosomal RNA small subunit methyltransferase E;
DE            EC=2.1.1.193;
DE   AltName: Full=16S rRNA m3U1498 methyltransferase;
GN   Name=rsmE; OrderedLocusNames=RP168;
OS   Rickettsia prowazekii (strain Madrid E).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX   NCBI_TaxID=272947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Madrid E;
RX   PubMed=9823893; DOI=10.1038/24094;
RA   Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T.,
RA   Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H.,
RA   Kurland C.G.;
RT   "The genome sequence of Rickettsia prowazekii and the origin of
RT   mitochondria.";
RL   Nature 396:133-140(1998).
CC   -!- FUNCTION: Specifically methylates the N3 position of the uracil ring of
CC       uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S
CC       ribosomal subunit (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) +
CC         N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:42920, Rhea:RHEA-COMP:10283, Rhea:RHEA-COMP:10284,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:65315, ChEBI:CHEBI:74502; EC=2.1.1.193;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RNA methyltransferase RsmE family.
CC       {ECO:0000305}.
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DR   EMBL; AJ235270; CAA14635.1; -; Genomic_DNA.
DR   PIR; D71727; D71727.
DR   RefSeq; NP_220558.1; NC_000963.1.
DR   AlphaFoldDB; Q9ZDZ5; -.
DR   SMR; Q9ZDZ5; -.
DR   STRING; 272947.gene:17555251; -.
DR   EnsemblBacteria; CAA14635; CAA14635; CAA14635.
DR   KEGG; rpr:RP168; -.
DR   PATRIC; fig|272947.5.peg.173; -.
DR   eggNOG; COG1385; Bacteria.
DR   HOGENOM; CLU_067442_4_0_5; -.
DR   OrthoDB; 9815641at2; -.
DR   Proteomes; UP000002480; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.1280.10; -; 1.
DR   InterPro; IPR029028; Alpha/beta_knot_MTases.
DR   InterPro; IPR015947; PUA-like_sf.
DR   InterPro; IPR006700; RsmE.
DR   InterPro; IPR046886; RsmE_MTase_dom.
DR   InterPro; IPR046887; RsmE_PUA-like.
DR   InterPro; IPR029026; tRNA_m1G_MTases_N.
DR   NCBIfam; TIGR00046; RsmE family RNA methyltransferase; 1.
DR   PANTHER; PTHR30027:SF3; 16S RRNA (URACIL(1498)-N(3))-METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR30027; RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE E; 1.
DR   Pfam; PF04452; Methyltrans_RNA; 1.
DR   Pfam; PF20260; PUA_4; 1.
DR   PIRSF; PIRSF015601; MTase_slr0722; 1.
DR   SUPFAM; SSF75217; alpha/beta knot; 1.
DR   SUPFAM; SSF88697; PUA domain-like; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Methyltransferase; Reference proteome; rRNA processing;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..198
FT                   /note="Ribosomal RNA small subunit methyltransferase E"
FT                   /id="PRO_0000176216"
SQ   SEQUENCE   198 AA;  22603 MW;  2BC7763BE94C4760 CRC64;
     MKYNRIYINS NLAENSKLEL ARDYVHYVKT VLRLKIHDSL RIFNGSDGEF LAQITQIGKN
     NLSVVLKEQL KKAYIESALT LAVAIIKSDK LMLTINMATQ LGITKIIPLI TRRCQFRTVN
     IERLMKCVIE ATEQSERLNP PIIEQAITLK DYLKKNNNLI LYANEHEKVK HSILHISSLL
     SKDIAIIIGP EEGLLMMS
//