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Q9ZDY3

- ODO1_RICPR

UniProt

Q9ZDY3 - ODO1_RICPR

Protein

2-oxoglutarate dehydrogenase E1 component

Gene

sucA

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

    Catalytic activityi

    2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

    Cofactori

    Thiamine pyrophosphate.By similarity

    GO - Molecular functioni

    1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
    2. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Thiamine pyrophosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
    Alternative name(s):
    Alpha-ketoglutarate dehydrogenase
    Gene namesi
    Name:sucA
    Ordered Locus Names:RP180
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9369362-oxoglutarate dehydrogenase E1 componentPRO_0000162196Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi272947.RP180.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZDY3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0567.
    HOGENOMiHOG000259588.
    KOiK00164.
    OMAiGHQNANL.
    OrthoDBiEOG6V1M1F.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    InterProiIPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view]
    PANTHERiPTHR23152. PTHR23152. 1 hit.
    PfamiPF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9ZDY3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEYFNKTGY LFSGNAVFVE ELYRQYLANP NSVDQTWQEF FADIKDNNVV    50
    LNKSTAKVIS TNVTNKELLN NNLSSETLNN LKAKEMISAY RRNAHYLANL 100
    DPLGLEIRKT KNDLKLNIEA FGLDSSQLGE NINIMDEFIG TWNCKLSELV 150
    TKLDKVYTSS IGVEFDQIEN VEEKNWLYTK LETDITFTSE EKKSILNDLV 200
    EVECFEQFLH IKFPGAKRFS IEGGDASIVA MNKAIDLSMH QGVEEIVIGM 250
    AHRGRLNTLT KVVGKPYKEV IASFINGNIF PDGLNVSGDV KYHLGYSADR 300
    VRANQKIHLS LADNPSHLEA INSIVAGKVR AKQDIFVDTK RSKIKAILVH 350
    GDAAFCGQGV VAESLSMSPL TAYNVGGILH FVINNQLGFT ANAADTRASR 400
    YSTEFAKIIS APILHVNGDD IEAVLKATDI AVEYRQKFSK DVVVEIICYR 450
    KYGHNEGDEP MYTQSKMYNI IKSKPTPGSI YANELVKNGI IDNNYYAKLK 500
    EKFKIRLDQE YEQAKSYKQE THFFEGYWKG ISRIRGKDAI TGVNKKILQD 550
    LGTKLCEIPK DFAINPKLIR LFEVRKTTLT TDQPIDWATA EQLAFAHLLC 600
    SGINIRLTGQ DSARGTFSHR HSILHNQIDD TTYIPLNNLS KTQAKYEVAN 650
    SNLSEYAALG FEYGYSLANP KNLVLWEAQF GDFANGAQII FDQFISSSAT 700
    KWLRMSGLVV LLPHAFEGQG PEHSSARLER FLQLAAEENM YITYPTTPAS 750
    IFHLLRRQIL ESTRKPLIVM SPKSLLRHKY AVSKLDELGE NTTFIPILDE 800
    VTKIDTNNVT KVILCSGKVY YDLFAMRTNN SNIVIIRLEQ LYPFEKKLVA 850
    SLLKKYNKAQ AFIWCQEEPK NMGAWHYIAT HLNDALKEAE INNEFKYVGR 900
    EESASPAVGS LQVHNKQQEK LLMEALGDDI IKEKLY 936
    Length:936
    Mass (Da):105,796
    Last modified:May 1, 1999 - v1
    Checksum:i30EA24895B4758AC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235270 Genomic DNA. Translation: CAA14647.1.
    PIRiH71728.
    RefSeqiNP_220570.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA14647; CAA14647; CAA14647.
    GeneIDi883867.
    KEGGirpr:RP180.
    PATRICi17901110. VBIRicPro72556_0185.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235270 Genomic DNA. Translation: CAA14647.1 .
    PIRi H71728.
    RefSeqi NP_220570.1. NC_000963.1.

    3D structure databases

    ProteinModelPortali Q9ZDY3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP180.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA14647 ; CAA14647 ; CAA14647 .
    GeneIDi 883867.
    KEGGi rpr:RP180.
    PATRICi 17901110. VBIRicPro72556_0185.

    Phylogenomic databases

    eggNOGi COG0567.
    HOGENOMi HOG000259588.
    KOi K00164.
    OMAi GHQNANL.
    OrthoDBi EOG6V1M1F.

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    InterProi IPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view ]
    PANTHERi PTHR23152. PTHR23152. 1 hit.
    Pfami PF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.

    Entry informationi

    Entry nameiODO1_RICPR
    AccessioniPrimary (citable) accession number: Q9ZDY3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3