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Q9ZDY3 (ODO1_RICPR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2-oxoglutarate dehydrogenase E1 component

EC=1.2.4.2
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene names
Name:sucA
Ordered Locus Names:RP180
OrganismRickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]
Taxonomic identifier272947 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length936 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activity

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactor

Thiamine pyrophosphate By similarity.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the alpha-ketoglutarate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9369362-oxoglutarate dehydrogenase E1 component
PRO_0000162196

Sequences

Sequence LengthMass (Da)Tools
Q9ZDY3 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 30EA24895B4758AC

FASTA936105,796
        10         20         30         40         50         60 
MEEYFNKTGY LFSGNAVFVE ELYRQYLANP NSVDQTWQEF FADIKDNNVV LNKSTAKVIS 

        70         80         90        100        110        120 
TNVTNKELLN NNLSSETLNN LKAKEMISAY RRNAHYLANL DPLGLEIRKT KNDLKLNIEA 

       130        140        150        160        170        180 
FGLDSSQLGE NINIMDEFIG TWNCKLSELV TKLDKVYTSS IGVEFDQIEN VEEKNWLYTK 

       190        200        210        220        230        240 
LETDITFTSE EKKSILNDLV EVECFEQFLH IKFPGAKRFS IEGGDASIVA MNKAIDLSMH 

       250        260        270        280        290        300 
QGVEEIVIGM AHRGRLNTLT KVVGKPYKEV IASFINGNIF PDGLNVSGDV KYHLGYSADR 

       310        320        330        340        350        360 
VRANQKIHLS LADNPSHLEA INSIVAGKVR AKQDIFVDTK RSKIKAILVH GDAAFCGQGV 

       370        380        390        400        410        420 
VAESLSMSPL TAYNVGGILH FVINNQLGFT ANAADTRASR YSTEFAKIIS APILHVNGDD 

       430        440        450        460        470        480 
IEAVLKATDI AVEYRQKFSK DVVVEIICYR KYGHNEGDEP MYTQSKMYNI IKSKPTPGSI 

       490        500        510        520        530        540 
YANELVKNGI IDNNYYAKLK EKFKIRLDQE YEQAKSYKQE THFFEGYWKG ISRIRGKDAI 

       550        560        570        580        590        600 
TGVNKKILQD LGTKLCEIPK DFAINPKLIR LFEVRKTTLT TDQPIDWATA EQLAFAHLLC 

       610        620        630        640        650        660 
SGINIRLTGQ DSARGTFSHR HSILHNQIDD TTYIPLNNLS KTQAKYEVAN SNLSEYAALG 

       670        680        690        700        710        720 
FEYGYSLANP KNLVLWEAQF GDFANGAQII FDQFISSSAT KWLRMSGLVV LLPHAFEGQG 

       730        740        750        760        770        780 
PEHSSARLER FLQLAAEENM YITYPTTPAS IFHLLRRQIL ESTRKPLIVM SPKSLLRHKY 

       790        800        810        820        830        840 
AVSKLDELGE NTTFIPILDE VTKIDTNNVT KVILCSGKVY YDLFAMRTNN SNIVIIRLEQ 

       850        860        870        880        890        900 
LYPFEKKLVA SLLKKYNKAQ AFIWCQEEPK NMGAWHYIAT HLNDALKEAE INNEFKYVGR 

       910        920        930 
EESASPAVGS LQVHNKQQEK LLMEALGDDI IKEKLY 

« Hide

References

[1]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ235270 Genomic DNA. Translation: CAA14647.1.
PIRH71728.
RefSeqNP_220570.1. NC_000963.1.

3D structure databases

ProteinModelPortalQ9ZDY3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272947.RP180.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAA14647; CAA14647; CAA14647.
GeneID883867.
KEGGrpr:RP180.
PATRIC17901110. VBIRicPro72556_0185.

Phylogenomic databases

eggNOGCOG0567.
HOGENOMHOG000259588.
KOK00164.
OMAGHQNANL.
OrthoDBEOG6V1M1F.

Family and domain databases

Gene3D3.40.50.970. 2 hits.
InterProIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERPTHR23152. PTHR23152. 1 hit.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52518. SSF52518. 2 hits.
TIGRFAMsTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetSearch...

Entry information

Entry nameODO1_RICPR
AccessionPrimary (citable) accession number: Q9ZDY3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names