Q9ZDY3 (ODO1_RICPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2-oxoglutarate dehydrogenase E1 component
EC=1.2.4.2

Alternative name(s):
Alpha-ketoglutarate dehydrogenase

Gene names

Name:	sucA
Ordered Locus Names:	RP180

Organism

Rickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]

Taxonomic identifier

272947 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group › Rickettsia prowazekii

Protein attributes

Sequence length	936 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.
Catalytic activity	2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.
Cofactor	Thiamine pyrophosphate By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the alpha-ketoglutarate dehydrogenase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Thiamine pyrophosphate
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity Inferred from electronic annotation. Source: EC thiamine pyrophosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 936	936	2-oxoglutarate dehydrogenase E1 component		PRO_0000162196

Sequences

	Sequence		Length	Mass (Da)
	Q9ZDY3 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 30EA24895B4758AC	FASTA	936	105,796
	10 20 30 40 50 60 MEEYFNKTGY LFSGNAVFVE ELYRQYLANP NSVDQTWQEF FADIKDNNVV LNKSTAKVIS 70 80 90 100 110 120 TNVTNKELLN NNLSSETLNN LKAKEMISAY RRNAHYLANL DPLGLEIRKT KNDLKLNIEA 130 140 150 160 170 180 FGLDSSQLGE NINIMDEFIG TWNCKLSELV TKLDKVYTSS IGVEFDQIEN VEEKNWLYTK 190 200 210 220 230 240 LETDITFTSE EKKSILNDLV EVECFEQFLH IKFPGAKRFS IEGGDASIVA MNKAIDLSMH 250 260 270 280 290 300 QGVEEIVIGM AHRGRLNTLT KVVGKPYKEV IASFINGNIF PDGLNVSGDV KYHLGYSADR 310 320 330 340 350 360 VRANQKIHLS LADNPSHLEA INSIVAGKVR AKQDIFVDTK RSKIKAILVH GDAAFCGQGV 370 380 390 400 410 420 VAESLSMSPL TAYNVGGILH FVINNQLGFT ANAADTRASR YSTEFAKIIS APILHVNGDD 430 440 450 460 470 480 IEAVLKATDI AVEYRQKFSK DVVVEIICYR KYGHNEGDEP MYTQSKMYNI IKSKPTPGSI 490 500 510 520 530 540 YANELVKNGI IDNNYYAKLK EKFKIRLDQE YEQAKSYKQE THFFEGYWKG ISRIRGKDAI 550 560 570 580 590 600 TGVNKKILQD LGTKLCEIPK DFAINPKLIR LFEVRKTTLT TDQPIDWATA EQLAFAHLLC 610 620 630 640 650 660 SGINIRLTGQ DSARGTFSHR HSILHNQIDD TTYIPLNNLS KTQAKYEVAN SNLSEYAALG 670 680 690 700 710 720 FEYGYSLANP KNLVLWEAQF GDFANGAQII FDQFISSSAT KWLRMSGLVV LLPHAFEGQG 730 740 750 760 770 780 PEHSSARLER FLQLAAEENM YITYPTTPAS IFHLLRRQIL ESTRKPLIVM SPKSLLRHKY 790 800 810 820 830 840 AVSKLDELGE NTTFIPILDE VTKIDTNNVT KVILCSGKVY YDLFAMRTNN SNIVIIRLEQ 850 860 870 880 890 900 LYPFEKKLVA SLLKKYNKAQ AFIWCQEEPK NMGAWHYIAT HLNDALKEAE INNEFKYVGR 910 920 930 EESASPAVGS LQVHNKQQEK LLMEALGDDI IKEKLY

References

[1]

"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ235270 Genomic DNA. Translation: CAA14647.1.
PIR	H71728.
RefSeq	NP_220570.1. NC_000963.1.
3D structure databases
ProteinModelPortal	Q9ZDY3.
ModBase	Search...
Protein-protein interaction databases
STRING	272947.RP180.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAA14647; CAA14647; CAA14647.
GeneID	883867.
KEGG	rpr:RP180.
PATRIC	17901110. VBIRicPro72556_0185.
Phylogenomic databases
eggNOG	COG0567.
HOGENOM	HOG000259588.
KO	K00164.
OMA	EKVAITR.
ProtClustDB	PRK09404.
Family and domain databases
InterPro	IPR011603. 2oxoglutarate_DH_E1. IPR001017. DH_E1. IPR005475. Transketolase-like_Pyr-bd. [Graphical view]
PANTHER	PTHR23152. PTHR23152. 1 hit.
Pfam	PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. [Graphical view]
PIRSF	PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
TIGRFAMs	TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ODO1_RICPR

Accession

Primary (citable) accession number: Q9ZDY3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program