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Q9ZDY3

- ODO1_RICPR

UniProt

Q9ZDY3 - ODO1_RICPR

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Protein

2-oxoglutarate dehydrogenase E1 component

Gene
sucA, RP180
Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate By similarity.

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:sucA
Ordered Locus Names:RP180
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9369362-oxoglutarate dehydrogenase E1 componentPRO_0000162196Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi272947.RP180.

Structurei

3D structure databases

ProteinModelPortaliQ9ZDY3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiGHQNANL.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZDY3-1 [UniParc]FASTAAdd to Basket

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MEEYFNKTGY LFSGNAVFVE ELYRQYLANP NSVDQTWQEF FADIKDNNVV    50
LNKSTAKVIS TNVTNKELLN NNLSSETLNN LKAKEMISAY RRNAHYLANL 100
DPLGLEIRKT KNDLKLNIEA FGLDSSQLGE NINIMDEFIG TWNCKLSELV 150
TKLDKVYTSS IGVEFDQIEN VEEKNWLYTK LETDITFTSE EKKSILNDLV 200
EVECFEQFLH IKFPGAKRFS IEGGDASIVA MNKAIDLSMH QGVEEIVIGM 250
AHRGRLNTLT KVVGKPYKEV IASFINGNIF PDGLNVSGDV KYHLGYSADR 300
VRANQKIHLS LADNPSHLEA INSIVAGKVR AKQDIFVDTK RSKIKAILVH 350
GDAAFCGQGV VAESLSMSPL TAYNVGGILH FVINNQLGFT ANAADTRASR 400
YSTEFAKIIS APILHVNGDD IEAVLKATDI AVEYRQKFSK DVVVEIICYR 450
KYGHNEGDEP MYTQSKMYNI IKSKPTPGSI YANELVKNGI IDNNYYAKLK 500
EKFKIRLDQE YEQAKSYKQE THFFEGYWKG ISRIRGKDAI TGVNKKILQD 550
LGTKLCEIPK DFAINPKLIR LFEVRKTTLT TDQPIDWATA EQLAFAHLLC 600
SGINIRLTGQ DSARGTFSHR HSILHNQIDD TTYIPLNNLS KTQAKYEVAN 650
SNLSEYAALG FEYGYSLANP KNLVLWEAQF GDFANGAQII FDQFISSSAT 700
KWLRMSGLVV LLPHAFEGQG PEHSSARLER FLQLAAEENM YITYPTTPAS 750
IFHLLRRQIL ESTRKPLIVM SPKSLLRHKY AVSKLDELGE NTTFIPILDE 800
VTKIDTNNVT KVILCSGKVY YDLFAMRTNN SNIVIIRLEQ LYPFEKKLVA 850
SLLKKYNKAQ AFIWCQEEPK NMGAWHYIAT HLNDALKEAE INNEFKYVGR 900
EESASPAVGS LQVHNKQQEK LLMEALGDDI IKEKLY 936
Length:936
Mass (Da):105,796
Last modified:May 1, 1999 - v1
Checksum:i30EA24895B4758AC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235270 Genomic DNA. Translation: CAA14647.1.
PIRiH71728.
RefSeqiNP_220570.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA14647; CAA14647; CAA14647.
GeneIDi883867.
KEGGirpr:RP180.
PATRICi17901110. VBIRicPro72556_0185.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235270 Genomic DNA. Translation: CAA14647.1 .
PIRi H71728.
RefSeqi NP_220570.1. NC_000963.1.

3D structure databases

ProteinModelPortali Q9ZDY3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272947.RP180.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAA14647 ; CAA14647 ; CAA14647 .
GeneIDi 883867.
KEGGi rpr:RP180.
PATRICi 17901110. VBIRicPro72556_0185.

Phylogenomic databases

eggNOGi COG0567.
HOGENOMi HOG000259588.
KOi K00164.
OMAi GHQNANL.
OrthoDBi EOG6V1M1F.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiODO1_RICPR
AccessioniPrimary (citable) accession number: Q9ZDY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi