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Protein

2-oxoglutarate dehydrogenase E1 component

Gene

sucA

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:sucA
Ordered Locus Names:RP180
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9369362-oxoglutarate dehydrogenase E1 componentPRO_0000162196Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi272947.RP180.

Structurei

3D structure databases

ProteinModelPortaliQ9ZDY3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiEHSNARP.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZDY3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEYFNKTGY LFSGNAVFVE ELYRQYLANP NSVDQTWQEF FADIKDNNVV
60 70 80 90 100
LNKSTAKVIS TNVTNKELLN NNLSSETLNN LKAKEMISAY RRNAHYLANL
110 120 130 140 150
DPLGLEIRKT KNDLKLNIEA FGLDSSQLGE NINIMDEFIG TWNCKLSELV
160 170 180 190 200
TKLDKVYTSS IGVEFDQIEN VEEKNWLYTK LETDITFTSE EKKSILNDLV
210 220 230 240 250
EVECFEQFLH IKFPGAKRFS IEGGDASIVA MNKAIDLSMH QGVEEIVIGM
260 270 280 290 300
AHRGRLNTLT KVVGKPYKEV IASFINGNIF PDGLNVSGDV KYHLGYSADR
310 320 330 340 350
VRANQKIHLS LADNPSHLEA INSIVAGKVR AKQDIFVDTK RSKIKAILVH
360 370 380 390 400
GDAAFCGQGV VAESLSMSPL TAYNVGGILH FVINNQLGFT ANAADTRASR
410 420 430 440 450
YSTEFAKIIS APILHVNGDD IEAVLKATDI AVEYRQKFSK DVVVEIICYR
460 470 480 490 500
KYGHNEGDEP MYTQSKMYNI IKSKPTPGSI YANELVKNGI IDNNYYAKLK
510 520 530 540 550
EKFKIRLDQE YEQAKSYKQE THFFEGYWKG ISRIRGKDAI TGVNKKILQD
560 570 580 590 600
LGTKLCEIPK DFAINPKLIR LFEVRKTTLT TDQPIDWATA EQLAFAHLLC
610 620 630 640 650
SGINIRLTGQ DSARGTFSHR HSILHNQIDD TTYIPLNNLS KTQAKYEVAN
660 670 680 690 700
SNLSEYAALG FEYGYSLANP KNLVLWEAQF GDFANGAQII FDQFISSSAT
710 720 730 740 750
KWLRMSGLVV LLPHAFEGQG PEHSSARLER FLQLAAEENM YITYPTTPAS
760 770 780 790 800
IFHLLRRQIL ESTRKPLIVM SPKSLLRHKY AVSKLDELGE NTTFIPILDE
810 820 830 840 850
VTKIDTNNVT KVILCSGKVY YDLFAMRTNN SNIVIIRLEQ LYPFEKKLVA
860 870 880 890 900
SLLKKYNKAQ AFIWCQEEPK NMGAWHYIAT HLNDALKEAE INNEFKYVGR
910 920 930
EESASPAVGS LQVHNKQQEK LLMEALGDDI IKEKLY
Length:936
Mass (Da):105,796
Last modified:May 1, 1999 - v1
Checksum:i30EA24895B4758AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235270 Genomic DNA. Translation: CAA14647.1.
PIRiH71728.
RefSeqiNP_220570.1. NC_000963.1.
WP_004598613.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA14647; CAA14647; CAA14647.
GeneIDi883867.
KEGGirpr:RP180.
PATRICi17901110. VBIRicPro72556_0185.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235270 Genomic DNA. Translation: CAA14647.1.
PIRiH71728.
RefSeqiNP_220570.1. NC_000963.1.
WP_004598613.1. NC_000963.1.

3D structure databases

ProteinModelPortaliQ9ZDY3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272947.RP180.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAA14647; CAA14647; CAA14647.
GeneIDi883867.
KEGGirpr:RP180.
PATRICi17901110. VBIRicPro72556_0185.

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiEHSNARP.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiODO1_RICPR
AccessioniPrimary (citable) accession number: Q9ZDY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 27, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.