Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q9ZDW5 (HSCA_RICPR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chaperone protein HscA homolog
Gene names
Name:hscA
Ordered Locus Names:RP200
OrganismRickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]
Taxonomic identifier272947 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group ›

Protein attributes

Sequence length593 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB By similarity. HAMAP-Rule MF_00679

Sequence similarities

Belongs to the heat shock protein 70 family.

Ontologies

Keywords
   LigandATP-binding
Nucleotide-binding
   Molecular functionChaperone
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processiron-sulfur cluster assembly

Inferred from electronic annotation. Source: InterPro

protein folding

Inferred from electronic annotation. Source: HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATPase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 593593Chaperone protein HscA homolog HAMAP-Rule MF_00679
PRO_0000078644

Sequences

Sequence LengthMass (Da)Tools
Q9ZDW5 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: AACB8D666AF55D21

FASTA59366,019
        10         20         30         40         50         60 
MQIIEITEPK QTDFQQKLQI AVGIDFGTTN SLIAIATNRK VKIIKSIGDK ELIPTTIDFI 

        70         80         90        100        110        120 
NEDLIIGNNK GLHSIKRLFG KTLKEILNTT TLFSLVKDYL DINSSELKLN FANKKMRIAE 

       130        140        150        160        170        180 
IAAEVFIYLK NQAEKQLKNN ITKAVITVPA HFNDAARGEI MLAAKIAGFE VLRLIAEPTA 

       190        200        210        220        230        240 
AAYAYGLNKN QTGRYLVYDL GGGTFDVSIL NIQEGIFQVI ATNGDNMLGG DDIDVVITQY 

       250        260        270        280        290        300 
LCNKFDLPHS IETLQLAKKA KEILTYKESF NNDIISINKQ TLEQLISPLV ERTINITQEC 

       310        320        330        340        350        360 
LEQSGNPNID GVILVGGTTR IPLIKDELYK AFKIDILSDI DPDKAVVCGA ALQAENLITQ 

       370        380        390        400        410        420 
HTNSLLIDVV PLSLGIELYG GIVEKIITRN TPIPIAVIKE FTTYADNQTG IQFHILQGER 

       430        440        450        460        470        480 
EMAADCRSLA RFELKGLPPM KAGNIRVEVT FAIDADGILS VSAYEKISNI SHNIEIKPNH 

       490        500        510        520        530        540 
GINKTEIETM LKNAYKNAKI DYTTRLLQEA VIETEALMSS IERSIIKLTK LLSESEISII 

       550        560        570        580        590 
NALLDNIKDA VQTRDQILIK NSIKEFKSKI KKYLDTKLNI NDLRKCKNSN QIK

« Hide

References

[1]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ235270 Genomic DNA. Translation: CAA14665.1.
PIRB71731.
RefSeqNP_220588.1. NC_000963.1.

3D structure databases

ProteinModelPortalQ9ZDW5.
ModBaseSearch...

Protein-protein interaction databases

STRING272947.RP200.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAA14665; CAA14665; CAA14665.
GeneID883905.
KEGGrpr:RP200.
PATRIC17901158. VBIRicPro72556_0209.

Phylogenomic databases

eggNOGCOG0443.
HOGENOMHOG000228136.
KOK04044.
OMAAAEVFIY.
ProtClustDBPRK01433.

Family and domain databases

HAMAPMF_00679. HscA.
InterProIPR018181. Heat_shock_70_CS.
IPR013126. Hsp_70_fam.
IPR010236. ISC_FeS_clus_asmbl_HscA.
[Graphical view]
PfamPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSPR00301. HEATSHOCK70.
PROSITEPS00297. HSP70_1. False negative.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHSCA_RICPR
AccessionPrimary (citable) accession number: Q9ZDW5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 1, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents