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Protein

Chaperone protein HscA homolog

Gene

hscA

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB (By similarity).By similarity

GO - Molecular functioni

  1. ATPase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. ATP catabolic process Source: InterPro
  2. iron-sulfur cluster assembly Source: InterPro
  3. protein folding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein HscA homolog
Gene namesi
Name:hscA
Ordered Locus Names:RP200
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 593593Chaperone protein HscA homologPRO_0000078644Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272947.RP200.

Structurei

3D structure databases

ProteinModelPortaliQ9ZDW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiCOG0443.
HOGENOMiHOG000228136.
KOiK04044.
OMAiSIDTKFN.
OrthoDBiEOG6JMMSV.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00679. HscA.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
IPR010236. ISC_FeS_clus_asmbl_HscA.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZDW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQIIEITEPK QTDFQQKLQI AVGIDFGTTN SLIAIATNRK VKIIKSIGDK
60 70 80 90 100
ELIPTTIDFI NEDLIIGNNK GLHSIKRLFG KTLKEILNTT TLFSLVKDYL
110 120 130 140 150
DINSSELKLN FANKKMRIAE IAAEVFIYLK NQAEKQLKNN ITKAVITVPA
160 170 180 190 200
HFNDAARGEI MLAAKIAGFE VLRLIAEPTA AAYAYGLNKN QTGRYLVYDL
210 220 230 240 250
GGGTFDVSIL NIQEGIFQVI ATNGDNMLGG DDIDVVITQY LCNKFDLPHS
260 270 280 290 300
IETLQLAKKA KEILTYKESF NNDIISINKQ TLEQLISPLV ERTINITQEC
310 320 330 340 350
LEQSGNPNID GVILVGGTTR IPLIKDELYK AFKIDILSDI DPDKAVVCGA
360 370 380 390 400
ALQAENLITQ HTNSLLIDVV PLSLGIELYG GIVEKIITRN TPIPIAVIKE
410 420 430 440 450
FTTYADNQTG IQFHILQGER EMAADCRSLA RFELKGLPPM KAGNIRVEVT
460 470 480 490 500
FAIDADGILS VSAYEKISNI SHNIEIKPNH GINKTEIETM LKNAYKNAKI
510 520 530 540 550
DYTTRLLQEA VIETEALMSS IERSIIKLTK LLSESEISII NALLDNIKDA
560 570 580 590
VQTRDQILIK NSIKEFKSKI KKYLDTKLNI NDLRKCKNSN QIK
Length:593
Mass (Da):66,019
Last modified:May 1, 1999 - v1
Checksum:iAACB8D666AF55D21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235270 Genomic DNA. Translation: CAA14665.1.
PIRiB71731.
RefSeqiNP_220588.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA14665; CAA14665; CAA14665.
GeneIDi883905.
KEGGirpr:RP200.
PATRICi17901158. VBIRicPro72556_0209.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235270 Genomic DNA. Translation: CAA14665.1.
PIRiB71731.
RefSeqiNP_220588.1. NC_000963.1.

3D structure databases

ProteinModelPortaliQ9ZDW5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272947.RP200.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAA14665; CAA14665; CAA14665.
GeneIDi883905.
KEGGirpr:RP200.
PATRICi17901158. VBIRicPro72556_0209.

Phylogenomic databases

eggNOGiCOG0443.
HOGENOMiHOG000228136.
KOiK04044.
OMAiSIDTKFN.
OrthoDBiEOG6JMMSV.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00679. HscA.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
IPR010236. ISC_FeS_clus_asmbl_HscA.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiHSCA_RICPR
AccessioniPrimary (citable) accession number: Q9ZDW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: March 4, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.