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Q9ZDW2

- UVRB_RICPR

UniProt

Q9ZDW2 - UVRB_RICPR

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Protein

UvrABC system protein B

Gene
uvrB, RP203
Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi38 – 458ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: UniProtKB-HAMAP
  3. excinuclease ABC activity Source: UniProtKB-HAMAP
  4. helicase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. nucleotide-excision repair Source: UniProtKB-HAMAP
  2. SOS response Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Excision nuclease

Keywords - Biological processi

DNA damage, DNA excision, DNA repair, SOS response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein B
Short name:
Protein UvrB
Alternative name(s):
Excinuclease ABC subunit B
Gene namesi
Name:uvrB
Ordered Locus Names:RP203
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 662662UvrABC system protein BUniRule annotationPRO_0000138421Add
BLAST

Interactioni

Subunit structurei

Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex By similarity.

Protein-protein interaction databases

STRINGi272947.RP203.

Structurei

3D structure databases

ProteinModelPortaliQ9ZDW2.
SMRiQ9ZDW2. Positions 2-593.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 414390Helicase ATP-bindingAdd
BLAST
Domaini430 – 592163Helicase C-terminalAdd
BLAST
Domaini622 – 65736UVRAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi91 – 11424Beta-hairpinUniRule annotationAdd
BLAST

Domaini

The beta-hairpin motif is involved in DNA binding By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the UvrB family.
Contains 1 UVR domain.

Phylogenomic databases

eggNOGiCOG0556.
HOGENOMiHOG000073580.
KOiK03702.
OMAiGDDWLIM.
OrthoDBiEOG6B360R.

Family and domain databases

Gene3Di3.40.50.300. 4 hits.
4.10.860.10. 1 hit.
HAMAPiMF_00204. UvrB.
InterProiIPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR001943. UVR_dom.
IPR004807. UvrB.
IPR024759. UvrB_YAD/RRR_dom.
[Graphical view]
PANTHERiPTHR24029. PTHR24029. 1 hit.
PfamiPF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF02151. UVR. 1 hit.
PF12344. UvrB. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00631. uvrb. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50151. UVR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZDW2-1 [UniParc]FASTAAdd to Basket

« Hide

MNNFSIISGY KPAGDQPKAI DEIITGLNSK KRSQMLLGIT GSGKTFTMAN    50
IIERTNRPTL IMAHNKTLAA QIYLEMKSIF PKNAVEYFVS YYDYYQPESY 100
IVRTDTFIEK DSSINEQIDL MRHSATRSLL ERRDVIVISS VSCIYGLGAP 150
DLYYQMTVHL EPGQNYPRDK LLNDLINLQY KRNDIGFERG CFRVKGDNMD 200
IFPSHYSDKA WRLSFFGDEL EYIHEFDPLT GEKLTQLDKA MIFGNSHFVM 250
PRERINHAIS SIEVELQKRL EFLKSQDKLI EAKRLNQRTL YDLEMLTETG 300
SCKGIENYSR FFTGRNAGQP PPTLFEYLPE DALLFIDESH VSVPQIRAMY 350
NSDRARKEVL VEHGFRLPSA LDNRPLKFEE WEKFRPQTVF VSATPGQFEL 400
EETGGTVVEL IIRPTGLLDP ECIIKPATNQ VEDLISEIQT TINTGLRILV 450
TTLTKKMAED LTSYLQDLQY KTYYLHSNIH TLERIEILRN LRQGTIDILV 500
GINLLREGID IPECGLVAIL DADKEGFLRS ETSLIQTIGR AARNSRGKVI 550
LYADKMTKSI DKAVSETLRR RQIQQEYNKK HGIIPKTINR AIHALESLEE 600
IHDNKLDKKQ ANALLNNPAK LKAHMDKLKK EMFKAASNLE FEQAAKLRNQ 650
LKALEEAALK LS 662
Length:662
Mass (Da):75,859
Last modified:May 1, 1999 - v1
Checksum:i3C58A49A5602421F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235270 Genomic DNA. Translation: CAA14668.1.
PIRiE71731.
RefSeqiNP_220591.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA14668; CAA14668; CAA14668.
GeneIDi883916.
KEGGirpr:RP203.
PATRICi17901164. VBIRicPro72556_0212.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235270 Genomic DNA. Translation: CAA14668.1 .
PIRi E71731.
RefSeqi NP_220591.1. NC_000963.1.

3D structure databases

ProteinModelPortali Q9ZDW2.
SMRi Q9ZDW2. Positions 2-593.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272947.RP203.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAA14668 ; CAA14668 ; CAA14668 .
GeneIDi 883916.
KEGGi rpr:RP203.
PATRICi 17901164. VBIRicPro72556_0212.

Phylogenomic databases

eggNOGi COG0556.
HOGENOMi HOG000073580.
KOi K03702.
OMAi GDDWLIM.
OrthoDBi EOG6B360R.

Family and domain databases

Gene3Di 3.40.50.300. 4 hits.
4.10.860.10. 1 hit.
HAMAPi MF_00204. UvrB.
InterProi IPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR001943. UVR_dom.
IPR004807. UvrB.
IPR024759. UvrB_YAD/RRR_dom.
[Graphical view ]
PANTHERi PTHR24029. PTHR24029. 1 hit.
Pfami PF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF02151. UVR. 1 hit.
PF12344. UvrB. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF46600. SSF46600. 1 hit.
SSF52540. SSF52540. 3 hits.
TIGRFAMsi TIGR00631. uvrb. 1 hit.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50151. UVR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiUVRB_RICPR
AccessioniPrimary (citable) accession number: Q9ZDW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi