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Q9ZDS8 (MURC_RICPR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramate--L-alanine ligase

EC=6.3.2.8
Alternative name(s):
UDP-N-acetylmuramoyl-L-alanine synthetase
Gene names
Name:murC
Ordered Locus Names:RP247
OrganismRickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]
Taxonomic identifier272947 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length495 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00046

Catalytic activity

ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. HAMAP-Rule MF_00046

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00046

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00046.

Sequence similarities

Belongs to the MurCDEF family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 495495UDP-N-acetylmuramate--L-alanine ligase HAMAP-Rule MF_00046
PRO_0000182143

Regions

Nucleotide binding120 – 1267ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q9ZDS8 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 2E18464088FAD2D6

FASTA49554,613
        10         20         30         40         50         60 
MLLLELKKTN QTLGTIHFIG IGGVGMSGIA EILHNLGYKV QGSDLVENYN TKRLESYGIK 

        70         80         90        100        110        120 
IFLGQAKQNI KNVSYVVISS AINQNNPEIK EALERKIPII RRAEMLAELM RLKCSVAVSG 

       130        140        150        160        170        180 
SHGKTTTTSL IACLFEAAGL CPTVINGGII NNKSTNAYLG SSNYLIAEAD ESDATFIHIP 

       190        200        210        220        230        240 
STIAIITNID PEHLDYYQDF EILIGAFRSF ITNLPFYGFA VCCIDHKIVR KLVDDITERK 

       250        260        270        280        290        300 
IITYGIDSED AHIIAFNINT DIASSTFDVK ISLPNVLGTT IIEKITIPTP GRHNILNSLA 

       310        320        330        340        350        360 
AIAVGIELDF GIKAIKNGFN NFKGVKRRFT KVAEYNKAVI IDDYAHHPEE IKATLATAKN 

       370        380        390        400        410        420 
IANQQNGKVI AIFQPHRYSR IKYLFDDFML CFADADILYI TNIYAAGETP IEGITGQSLV 

       430        440        450        460        470        480 
DKMTQNKHHD KANFLAELDD VVSIIIDNAA SGDMIIMMGA GNISSFANEL DRRLLSHEIL 

       490 
ENTDCDTKSN DKVMQ 

« Hide

References

[1]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ235271 Genomic DNA. Translation: CAA14709.1.
PIRC71679.
RefSeqNP_220632.1. NC_000963.1.

3D structure databases

ProteinModelPortalQ9ZDS8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272947.RP247.

Proteomic databases

PRIDEQ9ZDS8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAA14709; CAA14709; CAA14709.
GeneID884023.
KEGGrpr:RP247.
PATRIC17901254. VBIRicPro72556_0254.

Phylogenomic databases

eggNOGCOG0773.
HOGENOMHOG000256031.
KOK01924.
OMAVMVFQPH.
OrthoDBEOG64BQ73.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.40.1190.10. 1 hit.
3.40.50.720. 1 hit.
3.90.190.20. 1 hit.
HAMAPMF_00046. MurC.
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR016040. NAD(P)-bd_dom.
IPR005758. UDP-N-AcMur_Ala_ligase.
[Graphical view]
PfamPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsTIGR01082. murC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURC_RICPR
AccessionPrimary (citable) accession number: Q9ZDS8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways