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Q9ZDS8

- MURC_RICPR

UniProt

Q9ZDS8 - MURC_RICPR

Protein

UDP-N-acetylmuramate--L-alanine ligase

Gene

murC

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Cell wall formation.UniRule annotation

    Catalytic activityi

    ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi120 – 1267ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. UDP-N-acetylmuramate-L-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
    4. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-N-acetylmuramate--L-alanine ligaseUniRule annotation (EC:6.3.2.8UniRule annotation)
    Alternative name(s):
    UDP-N-acetylmuramoyl-L-alanine synthetaseUniRule annotation
    Gene namesi
    Name:murCUniRule annotation
    Ordered Locus Names:RP247
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 495495UDP-N-acetylmuramate--L-alanine ligasePRO_0000182143Add
    BLAST

    Proteomic databases

    PRIDEiQ9ZDS8.

    Interactioni

    Protein-protein interaction databases

    STRINGi272947.RP247.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZDS8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MurCDEF family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0773.
    HOGENOMiHOG000256031.
    KOiK01924.
    OMAiVMVFQPH.
    OrthoDBiEOG64BQ73.

    Family and domain databases

    Gene3Di3.40.1190.10. 1 hit.
    3.40.50.720. 1 hit.
    3.90.190.20. 1 hit.
    HAMAPiMF_00046. MurC.
    InterProiIPR004101. Mur_ligase_C.
    IPR013221. Mur_ligase_cen.
    IPR000713. Mur_ligase_N.
    IPR016040. NAD(P)-bd_dom.
    IPR005758. UDP-N-AcMur_Ala_ligase.
    [Graphical view]
    PfamiPF01225. Mur_ligase. 1 hit.
    PF02875. Mur_ligase_C. 1 hit.
    PF08245. Mur_ligase_M. 1 hit.
    [Graphical view]
    SUPFAMiSSF53244. SSF53244. 1 hit.
    SSF53623. SSF53623. 1 hit.
    TIGRFAMsiTIGR01082. murC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9ZDS8-1 [UniParc]FASTAAdd to Basket

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    MLLLELKKTN QTLGTIHFIG IGGVGMSGIA EILHNLGYKV QGSDLVENYN    50
    TKRLESYGIK IFLGQAKQNI KNVSYVVISS AINQNNPEIK EALERKIPII 100
    RRAEMLAELM RLKCSVAVSG SHGKTTTTSL IACLFEAAGL CPTVINGGII 150
    NNKSTNAYLG SSNYLIAEAD ESDATFIHIP STIAIITNID PEHLDYYQDF 200
    EILIGAFRSF ITNLPFYGFA VCCIDHKIVR KLVDDITERK IITYGIDSED 250
    AHIIAFNINT DIASSTFDVK ISLPNVLGTT IIEKITIPTP GRHNILNSLA 300
    AIAVGIELDF GIKAIKNGFN NFKGVKRRFT KVAEYNKAVI IDDYAHHPEE 350
    IKATLATAKN IANQQNGKVI AIFQPHRYSR IKYLFDDFML CFADADILYI 400
    TNIYAAGETP IEGITGQSLV DKMTQNKHHD KANFLAELDD VVSIIIDNAA 450
    SGDMIIMMGA GNISSFANEL DRRLLSHEIL ENTDCDTKSN DKVMQ 495
    Length:495
    Mass (Da):54,613
    Last modified:May 1, 1999 - v1
    Checksum:i2E18464088FAD2D6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235271 Genomic DNA. Translation: CAA14709.1.
    PIRiC71679.
    RefSeqiNP_220632.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA14709; CAA14709; CAA14709.
    GeneIDi884023.
    KEGGirpr:RP247.
    PATRICi17901254. VBIRicPro72556_0254.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235271 Genomic DNA. Translation: CAA14709.1 .
    PIRi C71679.
    RefSeqi NP_220632.1. NC_000963.1.

    3D structure databases

    ProteinModelPortali Q9ZDS8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP247.

    Proteomic databases

    PRIDEi Q9ZDS8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA14709 ; CAA14709 ; CAA14709 .
    GeneIDi 884023.
    KEGGi rpr:RP247.
    PATRICi 17901254. VBIRicPro72556_0254.

    Phylogenomic databases

    eggNOGi COG0773.
    HOGENOMi HOG000256031.
    KOi K01924.
    OMAi VMVFQPH.
    OrthoDBi EOG64BQ73.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .

    Family and domain databases

    Gene3Di 3.40.1190.10. 1 hit.
    3.40.50.720. 1 hit.
    3.90.190.20. 1 hit.
    HAMAPi MF_00046. MurC.
    InterProi IPR004101. Mur_ligase_C.
    IPR013221. Mur_ligase_cen.
    IPR000713. Mur_ligase_N.
    IPR016040. NAD(P)-bd_dom.
    IPR005758. UDP-N-AcMur_Ala_ligase.
    [Graphical view ]
    Pfami PF01225. Mur_ligase. 1 hit.
    PF02875. Mur_ligase_C. 1 hit.
    PF08245. Mur_ligase_M. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53244. SSF53244. 1 hit.
    SSF53623. SSF53623. 1 hit.
    TIGRFAMsi TIGR01082. murC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.

    Entry informationi

    Entry nameiMURC_RICPR
    AccessioniPrimary (citable) accession number: Q9ZDS8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3