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Q9ZDS8

- MURC_RICPR

UniProt

Q9ZDS8 - MURC_RICPR

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Protein

UDP-N-acetylmuramate--L-alanine ligase

Gene

murC

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotation

Catalytic activityi

ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi120 – 1267ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. UDP-N-acetylmuramate-L-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. cell wall organization Source: UniProtKB-KW
  4. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  5. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylmuramate--L-alanine ligaseUniRule annotation (EC:6.3.2.8UniRule annotation)
Alternative name(s):
UDP-N-acetylmuramoyl-L-alanine synthetaseUniRule annotation
Gene namesi
Name:murCUniRule annotation
Ordered Locus Names:RP247
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 495495UDP-N-acetylmuramate--L-alanine ligasePRO_0000182143Add
BLAST

Proteomic databases

PRIDEiQ9ZDS8.

Interactioni

Protein-protein interaction databases

STRINGi272947.RP247.

Structurei

3D structure databases

ProteinModelPortaliQ9ZDS8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MurCDEF family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0773.
HOGENOMiHOG000256031.
KOiK01924.
OMAiVMVFQPH.
OrthoDBiEOG64BQ73.

Family and domain databases

Gene3Di3.40.1190.10. 1 hit.
3.40.50.720. 1 hit.
3.90.190.20. 1 hit.
HAMAPiMF_00046. MurC.
InterProiIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR016040. NAD(P)-bd_dom.
IPR005758. UDP-N-AcMur_Ala_ligase.
[Graphical view]
PfamiPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMiSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsiTIGR01082. murC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZDS8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLLELKKTN QTLGTIHFIG IGGVGMSGIA EILHNLGYKV QGSDLVENYN
60 70 80 90 100
TKRLESYGIK IFLGQAKQNI KNVSYVVISS AINQNNPEIK EALERKIPII
110 120 130 140 150
RRAEMLAELM RLKCSVAVSG SHGKTTTTSL IACLFEAAGL CPTVINGGII
160 170 180 190 200
NNKSTNAYLG SSNYLIAEAD ESDATFIHIP STIAIITNID PEHLDYYQDF
210 220 230 240 250
EILIGAFRSF ITNLPFYGFA VCCIDHKIVR KLVDDITERK IITYGIDSED
260 270 280 290 300
AHIIAFNINT DIASSTFDVK ISLPNVLGTT IIEKITIPTP GRHNILNSLA
310 320 330 340 350
AIAVGIELDF GIKAIKNGFN NFKGVKRRFT KVAEYNKAVI IDDYAHHPEE
360 370 380 390 400
IKATLATAKN IANQQNGKVI AIFQPHRYSR IKYLFDDFML CFADADILYI
410 420 430 440 450
TNIYAAGETP IEGITGQSLV DKMTQNKHHD KANFLAELDD VVSIIIDNAA
460 470 480 490
SGDMIIMMGA GNISSFANEL DRRLLSHEIL ENTDCDTKSN DKVMQ
Length:495
Mass (Da):54,613
Last modified:May 1, 1999 - v1
Checksum:i2E18464088FAD2D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235271 Genomic DNA. Translation: CAA14709.1.
PIRiC71679.
RefSeqiNP_220632.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA14709; CAA14709; CAA14709.
GeneIDi884023.
KEGGirpr:RP247.
PATRICi17901254. VBIRicPro72556_0254.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235271 Genomic DNA. Translation: CAA14709.1 .
PIRi C71679.
RefSeqi NP_220632.1. NC_000963.1.

3D structure databases

ProteinModelPortali Q9ZDS8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272947.RP247.

Proteomic databases

PRIDEi Q9ZDS8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAA14709 ; CAA14709 ; CAA14709 .
GeneIDi 884023.
KEGGi rpr:RP247.
PATRICi 17901254. VBIRicPro72556_0254.

Phylogenomic databases

eggNOGi COG0773.
HOGENOMi HOG000256031.
KOi K01924.
OMAi VMVFQPH.
OrthoDBi EOG64BQ73.

Enzyme and pathway databases

UniPathwayi UPA00219 .

Family and domain databases

Gene3Di 3.40.1190.10. 1 hit.
3.40.50.720. 1 hit.
3.90.190.20. 1 hit.
HAMAPi MF_00046. MurC.
InterProi IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR016040. NAD(P)-bd_dom.
IPR005758. UDP-N-AcMur_Ala_ligase.
[Graphical view ]
Pfami PF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view ]
SUPFAMi SSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsi TIGR01082. murC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiMURC_RICPR
AccessioniPrimary (citable) accession number: Q9ZDS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3