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Protein

Cytochrome c homolog

Gene

cycM

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May be involved in electron transfer from bc1 complex to aa3.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei84 – 841Heme (covalent)PROSITE-ProRule annotation
Binding sitei87 – 871Heme (covalent)PROSITE-ProRule annotation
Metal bindingi88 – 881Iron (heme axial ligand)PROSITE-ProRule annotation
Metal bindingi150 – 1501Iron (heme axial ligand)PROSITE-ProRule annotation

GO - Molecular functioni

  1. electron carrier activity Source: InterPro
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. oxidation-reduction process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c homolog
Gene namesi
Name:cycM
Ordered Locus Names:RP253
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88CytoplasmicSequence Analysis
Transmembranei9 – 2921Helical; Signal-anchorSequence AnalysisAdd
BLAST
Topological domaini30 – 175146PeriplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 175175Cytochrome c homologPRO_0000288758Add
BLAST

Post-translational modificationi

Binds 1 heme group per subunit.By similarity

Interactioni

Protein-protein interaction databases

STRINGi272947.RP253.

Structurei

3D structure databases

ProteinModelPortaliQ9ZDS2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG3474.
HOGENOMiHOG000009763.
KOiK08738.
OMAiQHRGYSV.
OrthoDBiEOG6MM1PX.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZDS2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGKELNKIV AAILFASLIA MIVGFIANIL YKPNLHVLHR GYSIAIQKSS
60 70 80 90 100
SNESATVIAQ ESVNIQELMK TANANHGREI AKKCLMCHSL DKDGPNKLGP
110 120 130 140 150
HLWNIVGRPK ASITDYKYSF AISKLGGVWD DENLFAFLHK PSSYAPGTKM
160 170
SFAGISKPQD IADVILFLKN YVHDQ
Length:175
Mass (Da):19,286
Last modified:May 1, 1999 - v1
Checksum:i5E3422344225017D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235271 Genomic DNA. Translation: CAA14715.1.
PIRiA71680.
RefSeqiNP_220638.1. NC_000963.1.

Genome annotation databases

GeneIDi883146.
KEGGirpr:RP253.
PATRICi17901266. VBIRicPro72556_0260.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235271 Genomic DNA. Translation: CAA14715.1.
PIRiA71680.
RefSeqiNP_220638.1. NC_000963.1.

3D structure databases

ProteinModelPortaliQ9ZDS2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272947.RP253.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi883146.
KEGGirpr:RP253.
PATRICi17901266. VBIRicPro72556_0260.

Phylogenomic databases

eggNOGiCOG3474.
HOGENOMiHOG000009763.
KOiK08738.
OMAiQHRGYSV.
OrthoDBiEOG6MM1PX.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiCYCM_RICPR
AccessioniPrimary (citable) accession number: Q9ZDS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 1, 1999
Last modified: April 1, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.