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Protein

UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Gene

lpxC

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.By similarity

Catalytic activityi

UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + H2O = UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine + acetate.

Pathway: lipid IV(A) biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine.
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (lpxA)
  2. UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (lpxC)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. Lipid-A-disaccharide synthase (lpxB)
  6. Tetraacyldisaccharide 4'-kinase (lpxK)
This subpathway is part of the pathway lipid IV(A) biosynthesis, which is itself part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine, the pathway lipid IV(A) biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00359; UER00478.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (EC:3.5.1.-)
Alternative name(s):
UDP-3-O-acyl-GlcNAc deacetylase
Gene namesi
Name:lpxC
Ordered Locus Names:RP254
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylasePRO_0000191951Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272947.RP254.

Structurei

3D structure databases

ProteinModelPortaliQ9ZDS1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxC family.Curated

Phylogenomic databases

eggNOGiCOG0774.
HOGENOMiHOG000256664.
KOiK02535.
OMAiKAYKSGH.
OrthoDBiEOG6PGK74.

Family and domain databases

Gene3Di3.30.1700.10. 1 hit.
3.30.230.20. 1 hit.
HAMAPiMF_00388. LpxC.
InterProiIPR020568. Ribosomal_S5_D2-typ_fold.
IPR004463. UDP-acyl_GlcNac_deAcase.
IPR011334. UDP-acyl_GlcNac_deAcase_C.
IPR015870. UDP-acyl_N-AcGlcN_deAcase_N.
[Graphical view]
PfamiPF03331. LpxC. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 2 hits.
TIGRFAMsiTIGR00325. lpxC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZDS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHQSTLLKPV SCYGIGVHTG KRTQLTIEPA KENTGIIFIR TDISSENNYI
60 70 80 90 100
EASYCNVSDT LLSTTISNNH KIQISTIEHL MAALWGCSID NAIIKIDGPE
110 120 130 140 150
VPIMDGSSKP FVFMIECAGK KLQNAPKKYL KILKEVKVVN KDCELYCTPS
160 170 180 190 200
EHMAVDLTID FSSKAIGRQN LSFGMQESFT KNIADARTFG FIRDVEYLKS
210 220 230 240 250
KGLAQGASFE NAIGIDEHDK VLNPSGLRYA DEFVRHKLLD LFGDLYTSGI
260 270 280
SVVSAIKGYK TSHAFNNELL HKIFSDTTSY KFVTSNEL
Length:288
Mass (Da):32,008
Last modified:May 1, 1999 - v1
Checksum:i264F494AB39D286F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235271 Genomic DNA. Translation: CAA14716.1.
PIRiB71680.
RefSeqiNP_220639.1. NC_000963.1.
WP_004596080.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA14716; CAA14716; CAA14716.
GeneIDi883148.
KEGGirpr:RP254.
PATRICi17901268. VBIRicPro72556_0261.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235271 Genomic DNA. Translation: CAA14716.1.
PIRiB71680.
RefSeqiNP_220639.1. NC_000963.1.
WP_004596080.1. NC_000963.1.

3D structure databases

ProteinModelPortaliQ9ZDS1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272947.RP254.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAA14716; CAA14716; CAA14716.
GeneIDi883148.
KEGGirpr:RP254.
PATRICi17901268. VBIRicPro72556_0261.

Phylogenomic databases

eggNOGiCOG0774.
HOGENOMiHOG000256664.
KOiK02535.
OMAiKAYKSGH.
OrthoDBiEOG6PGK74.

Enzyme and pathway databases

UniPathwayiUPA00359; UER00478.

Family and domain databases

Gene3Di3.30.1700.10. 1 hit.
3.30.230.20. 1 hit.
HAMAPiMF_00388. LpxC.
InterProiIPR020568. Ribosomal_S5_D2-typ_fold.
IPR004463. UDP-acyl_GlcNac_deAcase.
IPR011334. UDP-acyl_GlcNac_deAcase_C.
IPR015870. UDP-acyl_N-AcGlcN_deAcase_N.
[Graphical view]
PfamiPF03331. LpxC. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 2 hits.
TIGRFAMsiTIGR00325. lpxC. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiLPXC_RICPR
AccessioniPrimary (citable) accession number: Q9ZDS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 1999
Last modified: May 27, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.