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Q9ZDS1

- LPXC_RICPR

UniProt

Q9ZDS1 - LPXC_RICPR

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Protein

UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Gene

lpxC

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.By similarity

Catalytic activityi

UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + H2O = UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine + acetate.

Pathwayi

GO - Molecular functioni

  1. UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity Source: InterPro

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00359; UER00478.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (EC:3.5.1.-)
Alternative name(s):
UDP-3-O-acyl-GlcNAc deacetylase
Gene namesi
Name:lpxC
Ordered Locus Names:RP254
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylasePRO_0000191951Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272947.RP254.

Structurei

3D structure databases

ProteinModelPortaliQ9ZDS1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxC family.Curated

Phylogenomic databases

eggNOGiCOG0774.
HOGENOMiHOG000256664.
KOiK02535.
OMAiKAYKSGH.
OrthoDBiEOG6PGK74.

Family and domain databases

Gene3Di3.30.1700.10. 1 hit.
3.30.230.20. 1 hit.
HAMAPiMF_00388. LpxC.
InterProiIPR020568. Ribosomal_S5_D2-typ_fold.
IPR004463. UDP-acyl_GlcNac_deAcase.
IPR011334. UDP-acyl_GlcNac_deAcase_C.
IPR015870. UDP-acyl_N-AcGlcN_deAcase_N.
[Graphical view]
PfamiPF03331. LpxC. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 2 hits.
TIGRFAMsiTIGR00325. lpxC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZDS1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHQSTLLKPV SCYGIGVHTG KRTQLTIEPA KENTGIIFIR TDISSENNYI
60 70 80 90 100
EASYCNVSDT LLSTTISNNH KIQISTIEHL MAALWGCSID NAIIKIDGPE
110 120 130 140 150
VPIMDGSSKP FVFMIECAGK KLQNAPKKYL KILKEVKVVN KDCELYCTPS
160 170 180 190 200
EHMAVDLTID FSSKAIGRQN LSFGMQESFT KNIADARTFG FIRDVEYLKS
210 220 230 240 250
KGLAQGASFE NAIGIDEHDK VLNPSGLRYA DEFVRHKLLD LFGDLYTSGI
260 270 280
SVVSAIKGYK TSHAFNNELL HKIFSDTTSY KFVTSNEL
Length:288
Mass (Da):32,008
Last modified:May 1, 1999 - v1
Checksum:i264F494AB39D286F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235271 Genomic DNA. Translation: CAA14716.1.
PIRiB71680.
RefSeqiNP_220639.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA14716; CAA14716; CAA14716.
GeneIDi883148.
KEGGirpr:RP254.
PATRICi17901268. VBIRicPro72556_0261.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235271 Genomic DNA. Translation: CAA14716.1 .
PIRi B71680.
RefSeqi NP_220639.1. NC_000963.1.

3D structure databases

ProteinModelPortali Q9ZDS1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272947.RP254.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAA14716 ; CAA14716 ; CAA14716 .
GeneIDi 883148.
KEGGi rpr:RP254.
PATRICi 17901268. VBIRicPro72556_0261.

Phylogenomic databases

eggNOGi COG0774.
HOGENOMi HOG000256664.
KOi K02535.
OMAi KAYKSGH.
OrthoDBi EOG6PGK74.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00478 .

Family and domain databases

Gene3Di 3.30.1700.10. 1 hit.
3.30.230.20. 1 hit.
HAMAPi MF_00388. LpxC.
InterProi IPR020568. Ribosomal_S5_D2-typ_fold.
IPR004463. UDP-acyl_GlcNac_deAcase.
IPR011334. UDP-acyl_GlcNac_deAcase_C.
IPR015870. UDP-acyl_N-AcGlcN_deAcase_N.
[Graphical view ]
Pfami PF03331. LpxC. 1 hit.
[Graphical view ]
SUPFAMi SSF54211. SSF54211. 2 hits.
TIGRFAMsi TIGR00325. lpxC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiLPXC_RICPR
AccessioniPrimary (citable) accession number: Q9ZDS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 1999
Last modified: October 1, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3