Q9ZDS1 (LPXC_RICPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
EC=3.5.1.-

Alternative name(s):
UDP-3-O-acyl-GlcNAc deacetylase

Gene names

Name:	lpxC
Ordered Locus Names:	RP254

Organism

Rickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]

Taxonomic identifier

272947 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group › Rickettsia prowazekii

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00388
Catalytic activity	UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + H2O = UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine + acetate. HAMAP-Rule MF_00388
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6. HAMAP-Rule MF_00388
Sequence similarities	Belongs to the LpxC family.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid biosynthesis Lipid metabolism
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 288	288	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase HAMAP-Rule MF_00388		PRO_0000191951

Sequences

	Sequence		Length	Mass (Da)
	Q9ZDS1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 264F494AB39D286F	FASTA	288	32,008
	10 20 30 40 50 60 MHQSTLLKPV SCYGIGVHTG KRTQLTIEPA KENTGIIFIR TDISSENNYI EASYCNVSDT 70 80 90 100 110 120 LLSTTISNNH KIQISTIEHL MAALWGCSID NAIIKIDGPE VPIMDGSSKP FVFMIECAGK 130 140 150 160 170 180 KLQNAPKKYL KILKEVKVVN KDCELYCTPS EHMAVDLTID FSSKAIGRQN LSFGMQESFT 190 200 210 220 230 240 KNIADARTFG FIRDVEYLKS KGLAQGASFE NAIGIDEHDK VLNPSGLRYA DEFVRHKLLD 250 260 270 280 LFGDLYTSGI SVVSAIKGYK TSHAFNNELL HKIFSDTTSY KFVTSNEL

References

[1]

"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ235271 Genomic DNA. Translation: CAA14716.1.
PIR	B71680.
RefSeq	NP_220639.1. NC_000963.1.
3D structure databases
ProteinModelPortal	Q9ZDS1.
ModBase	Search...
Protein-protein interaction databases
STRING	272947.RP254.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAA14716; CAA14716; CAA14716.
GeneID	883148.
KEGG	rpr:RP254.
PATRIC	17901268. VBIRicPro72556_0261.
Phylogenomic databases
eggNOG	COG0774.
HOGENOM	HOG000256664.
KO	K02535.
OMA	KAYKSGH.
ProtClustDB	PRK13186.
Enzyme and pathway databases
UniPathway	UPA00359; UER00478.
Family and domain databases
Gene3D	3.30.1700.10. 1 hit. 3.30.230.20. 1 hit.
HAMAP	MF_00388. LpxC.
InterPro	IPR020568. Ribosomal_S5_D2-typ_fold. IPR004463. UDP-acyl_GlcNac_deAcase. IPR011334. UDP-acyl_GlcNac_deAcase_C. IPR015870. UDP-acyl_N-AcGlcN_deAcase_N. [Graphical view]
Pfam	PF03331. LpxC. 1 hit. [Graphical view]
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 2 hits.
TIGRFAMs	TIGR00325. lpxC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LPXC_RICPR

Accession

Primary (citable) accession number: Q9ZDS1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program