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Q9ZDS1

- LPXC_RICPR

UniProt

Q9ZDS1 - LPXC_RICPR

Protein

UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Gene

lpxC

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.By similarity

    Catalytic activityi

    UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + H2O = UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine + acetate.

    Pathwayi

    GO - Molecular functioni

    1. UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity Source: InterPro

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00359; UER00478.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (EC:3.5.1.-)
    Alternative name(s):
    UDP-3-O-acyl-GlcNAc deacetylase
    Gene namesi
    Name:lpxC
    Ordered Locus Names:RP254
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 288288UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylasePRO_0000191951Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272947.RP254.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZDS1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxC family.Curated

    Phylogenomic databases

    eggNOGiCOG0774.
    HOGENOMiHOG000256664.
    KOiK02535.
    OMAiKAYKSGH.
    OrthoDBiEOG6PGK74.

    Family and domain databases

    Gene3Di3.30.1700.10. 1 hit.
    3.30.230.20. 1 hit.
    HAMAPiMF_00388. LpxC.
    InterProiIPR020568. Ribosomal_S5_D2-typ_fold.
    IPR004463. UDP-acyl_GlcNac_deAcase.
    IPR011334. UDP-acyl_GlcNac_deAcase_C.
    IPR015870. UDP-acyl_N-AcGlcN_deAcase_N.
    [Graphical view]
    PfamiPF03331. LpxC. 1 hit.
    [Graphical view]
    SUPFAMiSSF54211. SSF54211. 2 hits.
    TIGRFAMsiTIGR00325. lpxC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9ZDS1-1 [UniParc]FASTAAdd to Basket

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    MHQSTLLKPV SCYGIGVHTG KRTQLTIEPA KENTGIIFIR TDISSENNYI    50
    EASYCNVSDT LLSTTISNNH KIQISTIEHL MAALWGCSID NAIIKIDGPE 100
    VPIMDGSSKP FVFMIECAGK KLQNAPKKYL KILKEVKVVN KDCELYCTPS 150
    EHMAVDLTID FSSKAIGRQN LSFGMQESFT KNIADARTFG FIRDVEYLKS 200
    KGLAQGASFE NAIGIDEHDK VLNPSGLRYA DEFVRHKLLD LFGDLYTSGI 250
    SVVSAIKGYK TSHAFNNELL HKIFSDTTSY KFVTSNEL 288
    Length:288
    Mass (Da):32,008
    Last modified:May 1, 1999 - v1
    Checksum:i264F494AB39D286F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235271 Genomic DNA. Translation: CAA14716.1.
    PIRiB71680.
    RefSeqiNP_220639.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA14716; CAA14716; CAA14716.
    GeneIDi883148.
    KEGGirpr:RP254.
    PATRICi17901268. VBIRicPro72556_0261.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235271 Genomic DNA. Translation: CAA14716.1 .
    PIRi B71680.
    RefSeqi NP_220639.1. NC_000963.1.

    3D structure databases

    ProteinModelPortali Q9ZDS1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP254.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA14716 ; CAA14716 ; CAA14716 .
    GeneIDi 883148.
    KEGGi rpr:RP254.
    PATRICi 17901268. VBIRicPro72556_0261.

    Phylogenomic databases

    eggNOGi COG0774.
    HOGENOMi HOG000256664.
    KOi K02535.
    OMAi KAYKSGH.
    OrthoDBi EOG6PGK74.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00478 .

    Family and domain databases

    Gene3Di 3.30.1700.10. 1 hit.
    3.30.230.20. 1 hit.
    HAMAPi MF_00388. LpxC.
    InterProi IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR004463. UDP-acyl_GlcNac_deAcase.
    IPR011334. UDP-acyl_GlcNac_deAcase_C.
    IPR015870. UDP-acyl_N-AcGlcN_deAcase_N.
    [Graphical view ]
    Pfami PF03331. LpxC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54211. SSF54211. 2 hits.
    TIGRFAMsi TIGR00325. lpxC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.

    Entry informationi

    Entry nameiLPXC_RICPR
    AccessioniPrimary (citable) accession number: Q9ZDS1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3