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Protein

Pyruvate dehydrogenase E1 component subunit alpha

Gene

pdhA

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

  1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Pyruvate, Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit alpha (EC:1.2.4.1)
Gene namesi
Name:pdhA
Ordered Locus Names:RP261
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. intracellular membrane-bounded organelle Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Pyruvate dehydrogenase E1 component subunit alphaPRO_0000162204Add
BLAST

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.

Protein-protein interaction databases

STRINGi272947.RP261.

Structurei

3D structure databases

ProteinModelPortaliQ9ZDR4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG1071.
HOGENOMiHOG000281336.
KOiK00161.
OMAiRNHVQPI.
OrthoDBiEOG6JMMWC.

Family and domain databases

Gene3Di3.40.50.970. 1 hit.
InterProiIPR001017. DH_E1.
IPR017597. Pyrv_DH_E1_asu_subgrp-y.
IPR029061. THDP-binding.
[Graphical view]
PfamiPF00676. E1_dh. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 1 hit.
TIGRFAMsiTIGR03182. PDH_E1_alph_y. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZDR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIKPEKYKP IKEEYIKSFK DMLLLRRFEE KCGQLYGMGK IGGFCHLYIG
60 70 80 90 100
QEAVISAVAM IKKKGDSTIT SYRDHAHIIL AGTEPKYVLA ELMGRATGCS
110 120 130 140 150
KGKGGSMHLF DIPNKFYGGH GIVGAQVPIG TGLAFAEKYN GTNNICFTFL
160 170 180 190 200
GDGAVNQGQV YEAFNMASLW GLPIVYIIEN NEYSMGTSVA RSTFMCDLYK
210 220 230 240 250
KGESFGIRGF QLDGMDFEEM YNGTKQVAEY VRENSFPVIL EVKTYRYRGH
260 270 280 290 300
SMSDPAKYRS KEEVEKYKER DTLVRIREII LDNKYATEAD LKAIEQSVRE
310 320
IIKVAVEFSE NSPLPAEDEL YTEIYV
Length:326
Mass (Da):36,824
Last modified:May 1, 1999 - v1
Checksum:iBC9A6F66044B213A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235271 Genomic DNA. Translation: CAA14723.1.
PIRiA71681.
RefSeqiNP_220646.1. NC_000963.1.

Genome annotation databases

GeneIDi883166.
KEGGirpr:RP261.
PATRICi17901282. VBIRicPro72556_0268.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235271 Genomic DNA. Translation: CAA14723.1.
PIRiA71681.
RefSeqiNP_220646.1. NC_000963.1.

3D structure databases

ProteinModelPortaliQ9ZDR4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272947.RP261.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi883166.
KEGGirpr:RP261.
PATRICi17901282. VBIRicPro72556_0268.

Phylogenomic databases

eggNOGiCOG1071.
HOGENOMiHOG000281336.
KOiK00161.
OMAiRNHVQPI.
OrthoDBiEOG6JMMWC.

Family and domain databases

Gene3Di3.40.50.970. 1 hit.
InterProiIPR001017. DH_E1.
IPR017597. Pyrv_DH_E1_asu_subgrp-y.
IPR029061. THDP-binding.
[Graphical view]
PfamiPF00676. E1_dh. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 1 hit.
TIGRFAMsiTIGR03182. PDH_E1_alph_y. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiODPA_RICPR
AccessioniPrimary (citable) accession number: Q9ZDR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: April 1, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.