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Q9ZDR4

- ODPA_RICPR

UniProt

Q9ZDR4 - ODPA_RICPR

Protein

Pyruvate dehydrogenase E1 component subunit alpha

Gene

pdhA

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

    Catalytic activityi

    Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

    Cofactori

    Thiamine pyrophosphate.By similarity

    GO - Molecular functioni

    1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Pyruvate, Thiamine pyrophosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvate dehydrogenase E1 component subunit alpha (EC:1.2.4.1)
    Gene namesi
    Name:pdhA
    Ordered Locus Names:RP261
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular membrane-bounded organelle Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 326326Pyruvate dehydrogenase E1 component subunit alphaPRO_0000162204Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta chain.

    Protein-protein interaction databases

    STRINGi272947.RP261.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZDR4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG1071.
    HOGENOMiHOG000281336.
    KOiK00161.
    OMAiEYAMGTS.
    OrthoDBiEOG6JMMWC.

    Family and domain databases

    Gene3Di3.40.50.970. 1 hit.
    InterProiIPR001017. DH_E1.
    IPR017597. Pyrv_DH_E1_asu_subgrp-y.
    IPR029061. THDP-binding.
    [Graphical view]
    PfamiPF00676. E1_dh. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 1 hit.
    TIGRFAMsiTIGR03182. PDH_E1_alph_y. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9ZDR4-1 [UniParc]FASTAAdd to Basket

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    MDIKPEKYKP IKEEYIKSFK DMLLLRRFEE KCGQLYGMGK IGGFCHLYIG    50
    QEAVISAVAM IKKKGDSTIT SYRDHAHIIL AGTEPKYVLA ELMGRATGCS 100
    KGKGGSMHLF DIPNKFYGGH GIVGAQVPIG TGLAFAEKYN GTNNICFTFL 150
    GDGAVNQGQV YEAFNMASLW GLPIVYIIEN NEYSMGTSVA RSTFMCDLYK 200
    KGESFGIRGF QLDGMDFEEM YNGTKQVAEY VRENSFPVIL EVKTYRYRGH 250
    SMSDPAKYRS KEEVEKYKER DTLVRIREII LDNKYATEAD LKAIEQSVRE 300
    IIKVAVEFSE NSPLPAEDEL YTEIYV 326
    Length:326
    Mass (Da):36,824
    Last modified:May 1, 1999 - v1
    Checksum:iBC9A6F66044B213A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235271 Genomic DNA. Translation: CAA14723.1.
    PIRiA71681.
    RefSeqiNP_220646.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA14723; CAA14723; CAA14723.
    GeneIDi883166.
    KEGGirpr:RP261.
    PATRICi17901282. VBIRicPro72556_0268.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235271 Genomic DNA. Translation: CAA14723.1 .
    PIRi A71681.
    RefSeqi NP_220646.1. NC_000963.1.

    3D structure databases

    ProteinModelPortali Q9ZDR4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP261.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA14723 ; CAA14723 ; CAA14723 .
    GeneIDi 883166.
    KEGGi rpr:RP261.
    PATRICi 17901282. VBIRicPro72556_0268.

    Phylogenomic databases

    eggNOGi COG1071.
    HOGENOMi HOG000281336.
    KOi K00161.
    OMAi EYAMGTS.
    OrthoDBi EOG6JMMWC.

    Family and domain databases

    Gene3Di 3.40.50.970. 1 hit.
    InterProi IPR001017. DH_E1.
    IPR017597. Pyrv_DH_E1_asu_subgrp-y.
    IPR029061. THDP-binding.
    [Graphical view ]
    Pfami PF00676. E1_dh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 1 hit.
    TIGRFAMsi TIGR03182. PDH_E1_alph_y. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.

    Entry informationi

    Entry nameiODPA_RICPR
    AccessioniPrimary (citable) accession number: Q9ZDR4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names

    External Data

    Dasty 3