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Reviewed, UniProtKB/Swiss-Prot Q9ZDR0 (IDH_RICPR)

Last modified November 4, 2008. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Isocitrate dehydrogenase [NADP]
      Short name=IDH
    EC=1.1.1.42
Alternative name(s):
    Oxalosuccinate decarboxylase
    NADP(+)-specific ICDH
    IDP
Gene names
Name: icd
Ordered Locus Names: RP265
OrganismRickettsia prowazekii [Complete proteome] [HAMAP]
Taxonomic identifier782 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

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Protein attributes

Sequence length483 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH.

Oxalosuccinate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH.

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family.

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Ontologies

Keywords

   Biological processGlyoxylate bypass
Tricarboxylic acid cycle
   LigandMagnesium
Manganese
Metal-binding
NADP
   Molecular functionOxidoreductase
   PTMPhosphoprotein
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processglyoxylate cycle

Inferred from electronic annotation. Source: UniProtKB-KW

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionmagnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

manganese ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 483483Isocitrate dehydrogenase [NADP]
PRO_0000083557

Sites

Metal binding2081Magnesium or manganese By similarity
Metal binding2321Magnesium or manganese By similarity
Metal binding2361Magnesium or manganese By similarity
Binding site891Substrate By similarity
Binding site991Substrate By similarity
Binding site1211Substrate By similarity
Binding site2081Substrate By similarity
Site1281Critical for catalysis By similarity
Site1751Critical for catalysis By similarity

Amino acid modifications

Modified residue831Phosphoserine By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q9ZDR0-1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 17225FB9214E40A8

FASTA48354,318
        10         20         30         40         50         60 
MAAFTPITIA YGDGIGPEIM EAVLYILRKA EARISLETIE VGEKLYKKHY TSGISEESWD 

        70         80         90        100        110        120 
VIQRTGIILK APITTPQSGG YKSLNVTIRK TLQLFANIRP VVSFYPFTRT LHPNLNLTII 

       130        140        150        160        170        180 
RENEEDLYSG VEYRQTHNMY ESMKLISHTG CKKIIRYAFE YAIKNNRKKV TCLTKDNIMK 

       190        200        210        220        230        240 
FSDGIFHRVF NEIAKEYPQI NNEHYIIDIG TAKLATKPEI FDIIVTSNLY GDIISDVAAE 

       250        260        270        280        290        300 
ISGSVGLAGS ANIGQHYAMF EAVHGSAPDI AGKGIANPSG LLNAAIMMLV HIGQGDIASL 

       310        320        330        340        350        360 
IENAWKKTIE DGVHTFDIYN EHSSSKKVCT KEFAVEVIKR LGQLPITLPK AAYPLIVKKQ 

       370        380        390        400        410        420 
ESNIDYKIDT REVKKLVGTD IFINMHVFSA HDIADKINKL DIGNFELKTI SSKGLKLWPH 

       430        440        450        460        470        480 
DSRFEIISDH WCCRFMNKDG TEIKHLDITM LLQSLSKANI DFIKVENLFE FDGVAWYSLA 


QGE

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References

[1]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed: 9823893] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.

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Cross-references

Sequence databases

AJ235271 Genomic DNA. Translation: CAA14727.1.
PIRE71681.
RefSeqNP_220650.1.

3D structure databases

HSSPHSSP built from PDB template 1HQS based on UniProtKB P39126.
ModBaseSearch...

Genome annotation databases

GeneID883169.
GenomeReviewsGene locus RP265 in contig AJ235269_GR.
KEGGrpr:RP265.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ9ZDR0.

Enzyme and pathway databases

BioCycRPRO272947:RP265-MON.

Family and domain databases

InterProIPR001804. IsoCit_IM_DHase.
IPR014273. Isocitrate_DH_bac.
[Graphical view]
Gene3DG3DSA:3.40.718.10. IDH_IMDH. 1 hit.
PANTHERPTHR11835. IDH_IMDH_dimeric. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR02924. ICDH_alpha. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
BLOCKSSearch...
ProtoNetSearch...

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Entry information

Entry nameIDH_RICPR
AccessionPrimary (citable) accession number: Q9ZDR0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: November 4, 2008
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents