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Q9ZDR0 (IDH_RICPR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP]

Short name=IDH
EC=1.1.1.42
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene names
Name:icd
Ordered Locus Names:RP265
OrganismRickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]
Taxonomic identifier272947 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length483 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 483483Isocitrate dehydrogenase [NADP]
PRO_0000083557

Sites

Metal binding2081Magnesium or manganese By similarity
Metal binding2321Magnesium or manganese By similarity
Metal binding2361Magnesium or manganese By similarity
Binding site891Substrate By similarity
Binding site991Substrate By similarity
Binding site1211Substrate By similarity
Binding site2081Substrate By similarity
Site1281Critical for catalysis By similarity
Site1751Critical for catalysis By similarity

Amino acid modifications

Modified residue831Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ZDR0 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 17225FB9214E40A8

FASTA48354,318
        10         20         30         40         50         60 
MAAFTPITIA YGDGIGPEIM EAVLYILRKA EARISLETIE VGEKLYKKHY TSGISEESWD 

        70         80         90        100        110        120 
VIQRTGIILK APITTPQSGG YKSLNVTIRK TLQLFANIRP VVSFYPFTRT LHPNLNLTII 

       130        140        150        160        170        180 
RENEEDLYSG VEYRQTHNMY ESMKLISHTG CKKIIRYAFE YAIKNNRKKV TCLTKDNIMK 

       190        200        210        220        230        240 
FSDGIFHRVF NEIAKEYPQI NNEHYIIDIG TAKLATKPEI FDIIVTSNLY GDIISDVAAE 

       250        260        270        280        290        300 
ISGSVGLAGS ANIGQHYAMF EAVHGSAPDI AGKGIANPSG LLNAAIMMLV HIGQGDIASL 

       310        320        330        340        350        360 
IENAWKKTIE DGVHTFDIYN EHSSSKKVCT KEFAVEVIKR LGQLPITLPK AAYPLIVKKQ 

       370        380        390        400        410        420 
ESNIDYKIDT REVKKLVGTD IFINMHVFSA HDIADKINKL DIGNFELKTI SSKGLKLWPH 

       430        440        450        460        470        480 
DSRFEIISDH WCCRFMNKDG TEIKHLDITM LLQSLSKANI DFIKVENLFE FDGVAWYSLA 


QGE 

« Hide

References

[1]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ235271 Genomic DNA. Translation: CAA14727.1.
PIRE71681.
RefSeqNP_220650.1. NC_000963.1.

3D structure databases

ProteinModelPortalQ9ZDR0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272947.RP265.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAA14727; CAA14727; CAA14727.
GeneID883169.
KEGGrpr:RP265.
PATRIC17901290. VBIRicPro72556_0272.

Phylogenomic databases

eggNOGCOG0473.
HOGENOMHOG000021113.
KOK00031.
OMATPIAWEP.
OrthoDBEOG65XN31.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR014273. Isocitrate_DH_aproteobac-typ.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11835. PTHR11835. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR02924. ICDH_alpha. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIDH_RICPR
AccessionPrimary (citable) accession number: Q9ZDR0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names