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Q9ZDR0

- IDH_RICPR

UniProt

Q9ZDR0 - IDH_RICPR

Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei89 – 891SubstrateBy similarity
    Binding sitei99 – 991SubstrateBy similarity
    Binding sitei121 – 1211SubstrateBy similarity
    Sitei128 – 1281Critical for catalysisBy similarity
    Sitei175 – 1751Critical for catalysisBy similarity
    Metal bindingi208 – 2081Magnesium or manganeseBy similarity
    Binding sitei208 – 2081SubstrateBy similarity
    Metal bindingi232 – 2321Magnesium or manganeseBy similarity
    Metal bindingi236 – 2361Magnesium or manganeseBy similarity

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glyoxylate bypass, Tricarboxylic acid cycle

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding, NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
    Short name:
    IDH
    Alternative name(s):
    IDP
    NADP(+)-specific ICDH
    Oxalosuccinate decarboxylase
    Gene namesi
    Name:icd
    Ordered Locus Names:RP265
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 483483Isocitrate dehydrogenase [NADP]PRO_0000083557Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei83 – 831PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi272947.RP265.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZDR0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0473.
    HOGENOMiHOG000021113.
    KOiK00031.
    OMAiTPIAWEP.
    OrthoDBiEOG65XN31.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR014273. Isocitrate_DH_aproteobac-typ.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02924. ICDH_alpha. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZDR0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAFTPITIA YGDGIGPEIM EAVLYILRKA EARISLETIE VGEKLYKKHY    50
    TSGISEESWD VIQRTGIILK APITTPQSGG YKSLNVTIRK TLQLFANIRP 100
    VVSFYPFTRT LHPNLNLTII RENEEDLYSG VEYRQTHNMY ESMKLISHTG 150
    CKKIIRYAFE YAIKNNRKKV TCLTKDNIMK FSDGIFHRVF NEIAKEYPQI 200
    NNEHYIIDIG TAKLATKPEI FDIIVTSNLY GDIISDVAAE ISGSVGLAGS 250
    ANIGQHYAMF EAVHGSAPDI AGKGIANPSG LLNAAIMMLV HIGQGDIASL 300
    IENAWKKTIE DGVHTFDIYN EHSSSKKVCT KEFAVEVIKR LGQLPITLPK 350
    AAYPLIVKKQ ESNIDYKIDT REVKKLVGTD IFINMHVFSA HDIADKINKL 400
    DIGNFELKTI SSKGLKLWPH DSRFEIISDH WCCRFMNKDG TEIKHLDITM 450
    LLQSLSKANI DFIKVENLFE FDGVAWYSLA QGE 483
    Length:483
    Mass (Da):54,318
    Last modified:May 1, 1999 - v1
    Checksum:i17225FB9214E40A8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235271 Genomic DNA. Translation: CAA14727.1.
    PIRiE71681.
    RefSeqiNP_220650.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA14727; CAA14727; CAA14727.
    GeneIDi883169.
    KEGGirpr:RP265.
    PATRICi17901290. VBIRicPro72556_0272.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235271 Genomic DNA. Translation: CAA14727.1 .
    PIRi E71681.
    RefSeqi NP_220650.1. NC_000963.1.

    3D structure databases

    ProteinModelPortali Q9ZDR0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP265.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA14727 ; CAA14727 ; CAA14727 .
    GeneIDi 883169.
    KEGGi rpr:RP265.
    PATRICi 17901290. VBIRicPro72556_0272.

    Phylogenomic databases

    eggNOGi COG0473.
    HOGENOMi HOG000021113.
    KOi K00031.
    OMAi TPIAWEP.
    OrthoDBi EOG65XN31.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR014273. Isocitrate_DH_aproteobac-typ.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02924. ICDH_alpha. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.

    Entry informationi

    Entry nameiIDH_RICPR
    AccessioniPrimary (citable) accession number: Q9ZDR0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3