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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei89 – 891SubstrateBy similarity
Binding sitei99 – 991SubstrateBy similarity
Binding sitei121 – 1211SubstrateBy similarity
Sitei128 – 1281Critical for catalysisBy similarity
Sitei175 – 1751Critical for catalysisBy similarity
Metal bindingi208 – 2081Magnesium or manganeseBy similarity
Binding sitei208 – 2081SubstrateBy similarity
Metal bindingi232 – 2321Magnesium or manganeseBy similarity
Metal bindingi236 – 2361Magnesium or manganeseBy similarity

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene namesi
Name:icd
Ordered Locus Names:RP265
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 483483Isocitrate dehydrogenase [NADP]PRO_0000083557Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei83 – 831PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi272947.RP265.

Structurei

3D structure databases

ProteinModelPortaliQ9ZDR0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0473.
HOGENOMiHOG000021113.
KOiK00031.
OMAiQITTFAY.
OrthoDBiEOG65XN31.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR014273. Isocitrate_DH_aproteobac-typ.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02924. ICDH_alpha. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZDR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAFTPITIA YGDGIGPEIM EAVLYILRKA EARISLETIE VGEKLYKKHY
60 70 80 90 100
TSGISEESWD VIQRTGIILK APITTPQSGG YKSLNVTIRK TLQLFANIRP
110 120 130 140 150
VVSFYPFTRT LHPNLNLTII RENEEDLYSG VEYRQTHNMY ESMKLISHTG
160 170 180 190 200
CKKIIRYAFE YAIKNNRKKV TCLTKDNIMK FSDGIFHRVF NEIAKEYPQI
210 220 230 240 250
NNEHYIIDIG TAKLATKPEI FDIIVTSNLY GDIISDVAAE ISGSVGLAGS
260 270 280 290 300
ANIGQHYAMF EAVHGSAPDI AGKGIANPSG LLNAAIMMLV HIGQGDIASL
310 320 330 340 350
IENAWKKTIE DGVHTFDIYN EHSSSKKVCT KEFAVEVIKR LGQLPITLPK
360 370 380 390 400
AAYPLIVKKQ ESNIDYKIDT REVKKLVGTD IFINMHVFSA HDIADKINKL
410 420 430 440 450
DIGNFELKTI SSKGLKLWPH DSRFEIISDH WCCRFMNKDG TEIKHLDITM
460 470 480
LLQSLSKANI DFIKVENLFE FDGVAWYSLA QGE
Length:483
Mass (Da):54,318
Last modified:April 30, 1999 - v1
Checksum:i17225FB9214E40A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235271 Genomic DNA. Translation: CAA14727.1.
PIRiE71681.
RefSeqiNP_220650.1. NC_000963.1.

Genome annotation databases

GeneIDi883169.
KEGGirpr:RP265.
PATRICi17901290. VBIRicPro72556_0272.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235271 Genomic DNA. Translation: CAA14727.1.
PIRiE71681.
RefSeqiNP_220650.1. NC_000963.1.

3D structure databases

ProteinModelPortaliQ9ZDR0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272947.RP265.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi883169.
KEGGirpr:RP265.
PATRICi17901290. VBIRicPro72556_0272.

Phylogenomic databases

eggNOGiCOG0473.
HOGENOMiHOG000021113.
KOiK00031.
OMAiQITTFAY.
OrthoDBiEOG65XN31.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR014273. Isocitrate_DH_aproteobac-typ.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02924. ICDH_alpha. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiIDH_RICPR
AccessioniPrimary (citable) accession number: Q9ZDR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2000
Last sequence update: April 30, 1999
Last modified: March 31, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.