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Protein

Ubiquinol-cytochrome c reductase iron-sulfur subunit

Gene

petA

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.

Catalytic activityi

Quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+.

Cofactori

[2Fe-2S] clusterPROSITE-ProRule annotationNote: Binds 1 [2Fe-2S] cluster per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi120 – 1201Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation
Metal bindingi122 – 1221Iron-sulfur (2Fe-2S); via pros nitrogenPROSITE-ProRule annotation
Metal bindingi139 – 1391Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation
Metal bindingi142 – 1421Iron-sulfur (2Fe-2S); via pros nitrogenPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

2Fe-2S, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquinol-cytochrome c reductase iron-sulfur subunit (EC:1.10.2.2)
Alternative name(s):
Rieske iron-sulfur protein
Short name:
RISP
Gene namesi
Name:petA
Ordered Locus Names:RP270
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 3821HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 177177Ubiquinol-cytochrome c reductase iron-sulfur subunitPRO_0000127766Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi125 ↔ 141PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

Protein-protein interaction databases

STRINGi272947.RP270.

Structurei

3D structure databases

ProteinModelPortaliQ9ZDQ5.
SMRiQ9ZDQ5. Positions 118-163.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini88 – 17588RieskePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Rieske domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0723.
HOGENOMiHOG000255193.
KOiK00411.
OMAiQPAYAQN.
OrthoDBiEOG6RNQD9.

Family and domain databases

Gene3Di2.102.10.10. 1 hit.
InterProiIPR017941. Rieske_2Fe-2S.
IPR014349. Rieske_Fe-S_prot.
IPR005805. Rieske_Fe-S_prot_C.
IPR006311. TAT_signal.
IPR019546. TAT_signal_bac_arc.
IPR019470. Ubiq_cytC_Rdtase_Fe-S_su_TAT.
IPR006317. Ubiquinol_cyt_c_Rdtase_Fe-S-su.
[Graphical view]
PANTHERiPTHR10134. PTHR10134. 1 hit.
PfamiPF00355. Rieske. 1 hit.
PF10399. UCR_Fe-S_N. 1 hit.
[Graphical view]
PRINTSiPR00162. RIESKE.
SUPFAMiSSF50022. SSF50022. 1 hit.
TIGRFAMsiTIGR01416. Rieske_proteo. 1 hit.
TIGR01409. TAT_signal_seq. 1 hit.
PROSITEiPS51296. RIESKE. 1 hit.
PS51318. TAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZDQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDTEDNKNK QTTRRDFIVL TASSVAAVGA ACAFWPIIDS FNPSADVLAL
60 70 80 90 100
SSIEVDLSNI AIGQTVTVKW QGKPIFITNR THDEIAAARA VKMSELIDPE
110 120 130 140 150
RDEVRVKAGH DNWLVTIGIC THLGCVPLSH KGEYNGWFCP CHGSQYDSSG
160 170
RVRKGPAPLN LAVPPYIFIS DKKIRIG
Length:177
Mass (Da):19,350
Last modified:May 1, 1999 - v1
Checksum:iD6DA19D703A90B39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235271 Genomic DNA. Translation: CAA14732.1.
PIRiB71682.
RefSeqiNP_220655.1. NC_000963.1.
WP_004597339.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA14732; CAA14732; CAA14732.
GeneIDi883187.
KEGGirpr:RP270.
PATRICi17901301. VBIRicPro72556_0277.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235271 Genomic DNA. Translation: CAA14732.1.
PIRiB71682.
RefSeqiNP_220655.1. NC_000963.1.
WP_004597339.1. NC_000963.1.

3D structure databases

ProteinModelPortaliQ9ZDQ5.
SMRiQ9ZDQ5. Positions 118-163.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272947.RP270.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAA14732; CAA14732; CAA14732.
GeneIDi883187.
KEGGirpr:RP270.
PATRICi17901301. VBIRicPro72556_0277.

Phylogenomic databases

eggNOGiCOG0723.
HOGENOMiHOG000255193.
KOiK00411.
OMAiQPAYAQN.
OrthoDBiEOG6RNQD9.

Family and domain databases

Gene3Di2.102.10.10. 1 hit.
InterProiIPR017941. Rieske_2Fe-2S.
IPR014349. Rieske_Fe-S_prot.
IPR005805. Rieske_Fe-S_prot_C.
IPR006311. TAT_signal.
IPR019546. TAT_signal_bac_arc.
IPR019470. Ubiq_cytC_Rdtase_Fe-S_su_TAT.
IPR006317. Ubiquinol_cyt_c_Rdtase_Fe-S-su.
[Graphical view]
PANTHERiPTHR10134. PTHR10134. 1 hit.
PfamiPF00355. Rieske. 1 hit.
PF10399. UCR_Fe-S_N. 1 hit.
[Graphical view]
PRINTSiPR00162. RIESKE.
SUPFAMiSSF50022. SSF50022. 1 hit.
TIGRFAMsiTIGR01416. Rieske_proteo. 1 hit.
TIGR01409. TAT_signal_seq. 1 hit.
PROSITEiPS51296. RIESKE. 1 hit.
PS51318. TAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiUCRI_RICPR
AccessioniPrimary (citable) accession number: Q9ZDQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 1999
Last modified: May 27, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The Rieske protein is a high potential 2Fe-2S protein.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.