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Protein

Ubiquinol-cytochrome c reductase iron-sulfur subunit

Gene

petA

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.

Miscellaneous

The Rieske protein is a high potential 2Fe-2S protein.

Catalytic activityi

Quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+.

Cofactori

[2Fe-2S] clusterPROSITE-ProRule annotationNote: Binds 1 [2Fe-2S] cluster per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi120Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1
Metal bindingi122Iron-sulfur (2Fe-2S); via pros nitrogenPROSITE-ProRule annotation1
Metal bindingi139Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1
Metal bindingi142Iron-sulfur (2Fe-2S); via pros nitrogenPROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport
Ligand2Fe-2S, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquinol-cytochrome c reductase iron-sulfur subunit (EC:1.10.2.2)
Alternative name(s):
Rieske iron-sulfur protein
Short name:
RISP
Gene namesi
Name:petA
Ordered Locus Names:RP270
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000002480 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei18 – 38HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001277661 – 177Ubiquinol-cytochrome c reductase iron-sulfur subunitAdd BLAST177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi125 ↔ 141PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

Protein-protein interaction databases

STRINGi272947.RP270.

Structurei

3D structure databases

ProteinModelPortaliQ9ZDQ5.
SMRiQ9ZDQ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini88 – 175RieskePROSITE-ProRule annotationAdd BLAST88

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108R5F. Bacteria.
COG0723. LUCA.
HOGENOMiHOG000255193.
KOiK00411.
OMAiERKAFSY.

Family and domain databases

Gene3Di2.102.10.10. 1 hit.
InterProiView protein in InterPro
IPR017941. Rieske_2Fe-2S.
IPR014349. Rieske_Fe-S_prot.
IPR005805. Rieske_Fe-S_prot_C.
IPR006311. TAT_signal.
IPR019546. TAT_signal_bac_arc.
IPR019470. Ubiq_cytC_Rdtase_Fe-S_su_TAT.
IPR006317. Ubiquinol_cyt_c_Rdtase_Fe-S-su.
PANTHERiPTHR10134. PTHR10134. 1 hit.
PfamiView protein in Pfam
PF00355. Rieske. 1 hit.
PF10399. UCR_Fe-S_N. 1 hit.
PRINTSiPR00162. RIESKE.
SUPFAMiSSF50022. SSF50022. 1 hit.
TIGRFAMsiTIGR01416. Rieske_proteo. 1 hit.
TIGR01409. TAT_signal_seq. 1 hit.
PROSITEiView protein in PROSITE
PS51296. RIESKE. 1 hit.
PS51318. TAT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZDQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDTEDNKNK QTTRRDFIVL TASSVAAVGA ACAFWPIIDS FNPSADVLAL
60 70 80 90 100
SSIEVDLSNI AIGQTVTVKW QGKPIFITNR THDEIAAARA VKMSELIDPE
110 120 130 140 150
RDEVRVKAGH DNWLVTIGIC THLGCVPLSH KGEYNGWFCP CHGSQYDSSG
160 170
RVRKGPAPLN LAVPPYIFIS DKKIRIG
Length:177
Mass (Da):19,350
Last modified:May 1, 1999 - v1
Checksum:iD6DA19D703A90B39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235271 Genomic DNA. Translation: CAA14732.1.
PIRiB71682.
RefSeqiNP_220655.1. NC_000963.1.
WP_004597339.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA14732; CAA14732; CAA14732.
GeneIDi883187.
KEGGirpr:RP270.
PATRICifig|272947.5.peg.277.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235271 Genomic DNA. Translation: CAA14732.1.
PIRiB71682.
RefSeqiNP_220655.1. NC_000963.1.
WP_004597339.1. NC_000963.1.

3D structure databases

ProteinModelPortaliQ9ZDQ5.
SMRiQ9ZDQ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272947.RP270.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAA14732; CAA14732; CAA14732.
GeneIDi883187.
KEGGirpr:RP270.
PATRICifig|272947.5.peg.277.

Phylogenomic databases

eggNOGiENOG4108R5F. Bacteria.
COG0723. LUCA.
HOGENOMiHOG000255193.
KOiK00411.
OMAiERKAFSY.

Family and domain databases

Gene3Di2.102.10.10. 1 hit.
InterProiView protein in InterPro
IPR017941. Rieske_2Fe-2S.
IPR014349. Rieske_Fe-S_prot.
IPR005805. Rieske_Fe-S_prot_C.
IPR006311. TAT_signal.
IPR019546. TAT_signal_bac_arc.
IPR019470. Ubiq_cytC_Rdtase_Fe-S_su_TAT.
IPR006317. Ubiquinol_cyt_c_Rdtase_Fe-S-su.
PANTHERiPTHR10134. PTHR10134. 1 hit.
PfamiView protein in Pfam
PF00355. Rieske. 1 hit.
PF10399. UCR_Fe-S_N. 1 hit.
PRINTSiPR00162. RIESKE.
SUPFAMiSSF50022. SSF50022. 1 hit.
TIGRFAMsiTIGR01416. Rieske_proteo. 1 hit.
TIGR01409. TAT_signal_seq. 1 hit.
PROSITEiView protein in PROSITE
PS51296. RIESKE. 1 hit.
PS51318. TAT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUCRI_RICPR
AccessioniPrimary (citable) accession number: Q9ZDQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 1999
Last modified: June 7, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.