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Q9ZDK7

- LPXB_RICPR

UniProt

Q9ZDK7 - LPXB_RICPR

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.By similarity

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:RP321
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 380380Lipid-A-disaccharide synthasePRO_0000190182Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272947.RP321.

Structurei

3D structure databases

ProteinModelPortaliQ9ZDK7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.Curated

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZDK7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKIYFIAGE MSGDFIGGHV IQNLKSNEGL EFTGIGGKYM EEAGNFKSLF
60 70 80 90 100
TITAINLIGF IEIIPHLLKI KKLIDKTVEH IINSKADLLI TIDSPGFTYR
110 120 130 140 150
VAKRVRKLLP NLKMIHIVAP SVWAYKADRA VNYAKIYDCL FALLPFEPPY
160 170 180 190 200
FTKVGLDCRY IGHPIMEQEF YRDKIALRKE LKIDENERIL CVTLGTRKGE
210 220 230 240 250
ILRHLPIFID AIQEISKDYK NLTIIFPLAH PDHEAIIKPF LDNIQFNYLF
260 270 280 290 300
LSNERLKAYA VSDLALAKSG TNTLEISASG TPMVVAYKVN IISFIIIMLL
310 320 330 340 350
IKIKYVSLIN IIAGSEIIPE FIQFNCKANL ISNKLKELLS NSQKRYNQVV
360 370 380
KSKKILQKLG FESNRSPSYI AAKIIKQEFL
Length:380
Mass (Da):43,249
Last modified:May 1, 1999 - v1
Checksum:iE8718E4C5E6ECDD1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235271 Genomic DNA. Translation: CAA14781.1.
PIRiC71688.
RefSeqiNP_220704.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA14781; CAA14781; CAA14781.
GeneIDi883381.
KEGGirpr:RP321.
PATRICi17901409. VBIRicPro72556_0330.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235271 Genomic DNA. Translation: CAA14781.1 .
PIRi C71688.
RefSeqi NP_220704.1. NC_000963.1.

3D structure databases

ProteinModelPortali Q9ZDK7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272947.RP321.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAA14781 ; CAA14781 ; CAA14781 .
GeneIDi 883381.
KEGGi rpr:RP321.
PATRICi 17901409. VBIRicPro72556_0330.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiLPXB_RICPR
AccessioniPrimary (citable) accession number: Q9ZDK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 1999
Last modified: October 1, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3