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Q9ZDK7

- LPXB_RICPR

UniProt

Q9ZDK7 - LPXB_RICPR

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.By similarity

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthase (EC:2.4.1.182)
    Gene namesi
    Name:lpxB
    Ordered Locus Names:RP321
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 380380Lipid-A-disaccharide synthasePRO_0000190182Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272947.RP321.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZDK7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.Curated

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018004.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9ZDK7-1 [UniParc]FASTAAdd to Basket

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    MKKIYFIAGE MSGDFIGGHV IQNLKSNEGL EFTGIGGKYM EEAGNFKSLF    50
    TITAINLIGF IEIIPHLLKI KKLIDKTVEH IINSKADLLI TIDSPGFTYR 100
    VAKRVRKLLP NLKMIHIVAP SVWAYKADRA VNYAKIYDCL FALLPFEPPY 150
    FTKVGLDCRY IGHPIMEQEF YRDKIALRKE LKIDENERIL CVTLGTRKGE 200
    ILRHLPIFID AIQEISKDYK NLTIIFPLAH PDHEAIIKPF LDNIQFNYLF 250
    LSNERLKAYA VSDLALAKSG TNTLEISASG TPMVVAYKVN IISFIIIMLL 300
    IKIKYVSLIN IIAGSEIIPE FIQFNCKANL ISNKLKELLS NSQKRYNQVV 350
    KSKKILQKLG FESNRSPSYI AAKIIKQEFL 380
    Length:380
    Mass (Da):43,249
    Last modified:May 1, 1999 - v1
    Checksum:iE8718E4C5E6ECDD1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235271 Genomic DNA. Translation: CAA14781.1.
    PIRiC71688.
    RefSeqiNP_220704.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA14781; CAA14781; CAA14781.
    GeneIDi883381.
    KEGGirpr:RP321.
    PATRICi17901409. VBIRicPro72556_0330.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235271 Genomic DNA. Translation: CAA14781.1 .
    PIRi C71688.
    RefSeqi NP_220704.1. NC_000963.1.

    3D structure databases

    ProteinModelPortali Q9ZDK7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP321.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA14781 ; CAA14781 ; CAA14781 .
    GeneIDi 883381.
    KEGGi rpr:RP321.
    PATRICi 17901409. VBIRicPro72556_0330.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018004.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.

    Entry informationi

    Entry nameiLPXB_RICPR
    AccessioniPrimary (citable) accession number: Q9ZDK7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3