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Q9ZDH4

- NUOD_RICPR

UniProt

Q9ZDH4 - NUOD_RICPR

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Protein
NADH-quinone oxidoreductase subunit D
Gene
nuoD, RP354
Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.UniRule annotation

Catalytic activityi

NADH + quinone = NAD+ + quinol.UniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. NADH dehydrogenase (quinone) activity Source: UniProtKB-HAMAP
  3. quinone binding Source: UniProtKB-KW

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit D (EC:1.6.99.5)
Alternative name(s):
NADH dehydrogenase I subunit D
NDH-1 subunit D
Gene namesi
Name:nuoD
Ordered Locus Names:RP354
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389NADH-quinone oxidoreductase subunit DUniRule annotation
PRO_0000118625Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex By similarity.

Protein-protein interaction databases

STRINGi272947.RP354.

Structurei

3D structure databases

ProteinModelPortaliQ9ZDH4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0649.
HOGENOMiHOG000228264.
KOiK00333.
OMAiQCFALAV.
OrthoDBiEOG62G5MP.

Family and domain databases

Gene3Di1.10.645.10. 1 hit.
HAMAPiMF_01358. NDH1_NuoD.
InterProiIPR001135. NADH_Q_OxRdtase_suD.
IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
IPR022885. NDH1_su_D/H.
IPR029014. NiFe_Hase-like.
[Graphical view]
PfamiPF00346. Complex1_49kDa. 1 hit.
[Graphical view]
SUPFAMiSSF56762. SSF56762. 1 hit.
TIGRFAMsiTIGR01962. NuoD. 1 hit.
PROSITEiPS00535. COMPLEX1_49K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZDH4-1 [UniParc]FASTAAdd to Basket

« Hide

MTNKTITLNL GPQHPATHGV LRLILEMDGE VVNNADPHIG LLHRGTEKLI    50
EHKTYLQAIP YFDRLDYVSP MCQEHAFALA VESLLECSVP RRAQFIRVLF 100
SELTRILNHT LNIGSQALDI GATTPLLWLF EEREKIMEFY ERVSGSRMHS 150
NYFRPGGVAE DLPENLLEDI NKFIEQFPSK LNDIENLLNE NRLWKQRLVD 200
IGVVSQKDAM DWGFSGPMLR GSGIAWDLRK SNPYDVYDEM DFEVPIGKNG 250
DCYDRYLVRI LEMYESIKII KQCIVKMPKG QVKTDDPKLT PPTRGKMKES 300
MEAMIHHFKL YTEGYDVPIG ETYKAVEAPK GEFGVYLYSQ GGNKPYRCRI 350
KAPGFAHLQG LNFMSKGHLI ADVITIIATL DIVFGEIDR 389
Length:389
Mass (Da):44,426
Last modified:May 1, 1999 - v1
Checksum:i6FE30370150FC51D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235271 Genomic DNA. Translation: CAA14814.1.
PIRiD71692.
RefSeqiNP_220738.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA14814; CAA14814; CAA14814.
GeneIDi883390.
KEGGirpr:RP354.
PATRICi17901477. VBIRicPro72556_0364.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235271 Genomic DNA. Translation: CAA14814.1 .
PIRi D71692.
RefSeqi NP_220738.1. NC_000963.1.

3D structure databases

ProteinModelPortali Q9ZDH4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272947.RP354.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAA14814 ; CAA14814 ; CAA14814 .
GeneIDi 883390.
KEGGi rpr:RP354.
PATRICi 17901477. VBIRicPro72556_0364.

Phylogenomic databases

eggNOGi COG0649.
HOGENOMi HOG000228264.
KOi K00333.
OMAi QCFALAV.
OrthoDBi EOG62G5MP.

Family and domain databases

Gene3Di 1.10.645.10. 1 hit.
HAMAPi MF_01358. NDH1_NuoD.
InterProi IPR001135. NADH_Q_OxRdtase_suD.
IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
IPR022885. NDH1_su_D/H.
IPR029014. NiFe_Hase-like.
[Graphical view ]
Pfami PF00346. Complex1_49kDa. 1 hit.
[Graphical view ]
SUPFAMi SSF56762. SSF56762. 1 hit.
TIGRFAMsi TIGR01962. NuoD. 1 hit.
PROSITEi PS00535. COMPLEX1_49K. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiNUOD_RICPR
AccessioniPrimary (citable) accession number: Q9ZDH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi