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Q9ZDH4

- NUOD_RICPR

UniProt

Q9ZDH4 - NUOD_RICPR

Protein

NADH-quinone oxidoreductase subunit D

Gene

nuoD

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

    Catalytic activityi

    NADH + quinone = NAD+ + quinol.UniRule annotation

    GO - Molecular functioni

    1. NAD binding Source: InterPro
    2. NADH dehydrogenase (quinone) activity Source: UniProtKB-HAMAP
    3. quinone binding Source: UniProtKB-KW

    GO - Biological processi

    1. transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-quinone oxidoreductase subunit DUniRule annotation (EC:1.6.99.5UniRule annotation)
    Alternative name(s):
    NADH dehydrogenase I subunit DUniRule annotation
    NDH-1 subunit DUniRule annotation
    Gene namesi
    Name:nuoDUniRule annotation
    Ordered Locus Names:RP354
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 389389NADH-quinone oxidoreductase subunit DPRO_0000118625Add
    BLAST

    Keywords - PTMi

    Quinone

    Interactioni

    Subunit structurei

    NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi272947.RP354.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZDH4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I 49 kDa subunit family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0649.
    HOGENOMiHOG000228264.
    KOiK00333.
    OMAiQCFALAV.
    OrthoDBiEOG62G5MP.

    Family and domain databases

    Gene3Di1.10.645.10. 1 hit.
    HAMAPiMF_01358. NDH1_NuoD.
    InterProiIPR001135. NADH_Q_OxRdtase_suD.
    IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
    IPR022885. NDH1_su_D/H.
    IPR029014. NiFe_Hase-like.
    [Graphical view]
    PfamiPF00346. Complex1_49kDa. 1 hit.
    [Graphical view]
    SUPFAMiSSF56762. SSF56762. 1 hit.
    TIGRFAMsiTIGR01962. NuoD. 1 hit.
    PROSITEiPS00535. COMPLEX1_49K. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZDH4-1 [UniParc]FASTAAdd to Basket

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    MTNKTITLNL GPQHPATHGV LRLILEMDGE VVNNADPHIG LLHRGTEKLI    50
    EHKTYLQAIP YFDRLDYVSP MCQEHAFALA VESLLECSVP RRAQFIRVLF 100
    SELTRILNHT LNIGSQALDI GATTPLLWLF EEREKIMEFY ERVSGSRMHS 150
    NYFRPGGVAE DLPENLLEDI NKFIEQFPSK LNDIENLLNE NRLWKQRLVD 200
    IGVVSQKDAM DWGFSGPMLR GSGIAWDLRK SNPYDVYDEM DFEVPIGKNG 250
    DCYDRYLVRI LEMYESIKII KQCIVKMPKG QVKTDDPKLT PPTRGKMKES 300
    MEAMIHHFKL YTEGYDVPIG ETYKAVEAPK GEFGVYLYSQ GGNKPYRCRI 350
    KAPGFAHLQG LNFMSKGHLI ADVITIIATL DIVFGEIDR 389
    Length:389
    Mass (Da):44,426
    Last modified:May 1, 1999 - v1
    Checksum:i6FE30370150FC51D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235271 Genomic DNA. Translation: CAA14814.1.
    PIRiD71692.
    RefSeqiNP_220738.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA14814; CAA14814; CAA14814.
    GeneIDi883390.
    KEGGirpr:RP354.
    PATRICi17901477. VBIRicPro72556_0364.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235271 Genomic DNA. Translation: CAA14814.1 .
    PIRi D71692.
    RefSeqi NP_220738.1. NC_000963.1.

    3D structure databases

    ProteinModelPortali Q9ZDH4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP354.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA14814 ; CAA14814 ; CAA14814 .
    GeneIDi 883390.
    KEGGi rpr:RP354.
    PATRICi 17901477. VBIRicPro72556_0364.

    Phylogenomic databases

    eggNOGi COG0649.
    HOGENOMi HOG000228264.
    KOi K00333.
    OMAi QCFALAV.
    OrthoDBi EOG62G5MP.

    Family and domain databases

    Gene3Di 1.10.645.10. 1 hit.
    HAMAPi MF_01358. NDH1_NuoD.
    InterProi IPR001135. NADH_Q_OxRdtase_suD.
    IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
    IPR022885. NDH1_su_D/H.
    IPR029014. NiFe_Hase-like.
    [Graphical view ]
    Pfami PF00346. Complex1_49kDa. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56762. SSF56762. 1 hit.
    TIGRFAMsi TIGR01962. NuoD. 1 hit.
    PROSITEi PS00535. COMPLEX1_49K. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.

    Entry informationi

    Entry nameiNUOD_RICPR
    AccessioniPrimary (citable) accession number: Q9ZDH4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3