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Protein

NADH-quinone oxidoreductase subunit D

Gene

nuoD

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

Catalytic activityi

NADH + a quinone = NAD+ + a quinol.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processTransport
LigandNAD, Ubiquinone

Enzyme and pathway databases

BioCyciRPRO272947:G1GT0-357-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit DUniRule annotation (EC:1.6.5.11UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit DUniRule annotation
NDH-1 subunit DUniRule annotation
Gene namesi
Name:nuoDUniRule annotation
Ordered Locus Names:RP354
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000002480 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001186251 – 389NADH-quinone oxidoreductase subunit DAdd BLAST389

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.UniRule annotation

Protein-protein interaction databases

STRINGi272947.RP354

Structurei

3D structure databases

ProteinModelPortaliQ9ZDH4
SMRiQ9ZDH4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 49 kDa subunit family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CQV Bacteria
COG0649 LUCA
HOGENOMiHOG000228264
KOiK00333
OMAiKKIAWPA

Family and domain databases

Gene3Di1.10.645.20, 1 hit
HAMAPiMF_01358 NDH1_NuoD, 1 hit
InterProiView protein in InterPro
IPR001135 NADH_Q_OxRdtase_suD
IPR038290 NADH_Q_OxRdtase_suD_sf
IPR014029 NADH_UbQ_OxRdtase_49kDa_CS
IPR022885 NDH1_su_D/H
IPR029014 NiFe-Hase_large
PfamiView protein in Pfam
PF00346 Complex1_49kDa, 1 hit
SUPFAMiSSF56762 SSF56762, 1 hit
TIGRFAMsiTIGR01962 NuoD, 1 hit
PROSITEiView protein in PROSITE
PS00535 COMPLEX1_49K, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ZDH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNKTITLNL GPQHPATHGV LRLILEMDGE VVNNADPHIG LLHRGTEKLI
60 70 80 90 100
EHKTYLQAIP YFDRLDYVSP MCQEHAFALA VESLLECSVP RRAQFIRVLF
110 120 130 140 150
SELTRILNHT LNIGSQALDI GATTPLLWLF EEREKIMEFY ERVSGSRMHS
160 170 180 190 200
NYFRPGGVAE DLPENLLEDI NKFIEQFPSK LNDIENLLNE NRLWKQRLVD
210 220 230 240 250
IGVVSQKDAM DWGFSGPMLR GSGIAWDLRK SNPYDVYDEM DFEVPIGKNG
260 270 280 290 300
DCYDRYLVRI LEMYESIKII KQCIVKMPKG QVKTDDPKLT PPTRGKMKES
310 320 330 340 350
MEAMIHHFKL YTEGYDVPIG ETYKAVEAPK GEFGVYLYSQ GGNKPYRCRI
360 370 380
KAPGFAHLQG LNFMSKGHLI ADVITIIATL DIVFGEIDR
Length:389
Mass (Da):44,426
Last modified:May 1, 1999 - v1
Checksum:i6FE30370150FC51D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235271 Genomic DNA Translation: CAA14814.1
PIRiD71692
RefSeqiNP_220738.1, NC_000963.1
WP_010886274.1, NC_000963.1

Genome annotation databases

EnsemblBacteriaiCAA14814; CAA14814; CAA14814
GeneIDi883390
KEGGirpr:RP354
PATRICifig|272947.5.peg.364

Similar proteinsi

Entry informationi

Entry nameiNUOD_RICPR
AccessioniPrimary (citable) accession number: Q9ZDH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health