Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q9ZDH3 (NUOC_RICPR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-quinone oxidoreductase subunit C

EC=1.6.99.5
Alternative name(s):
NADH dehydrogenase I subunit C
NDH-1 subunit C
Gene names
Name:nuoC
Ordered Locus Names:RP355
OrganismRickettsia prowazekii (strain Madrid E)
Taxonomic identifier272947 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length197 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity. HAMAP MF_01357

Catalytic activity

NADH + quinone = NAD+ + quinol. HAMAP MF_01357

Subunit structure

NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex By similarity.

Subcellular location

Cell inner membrane; Peripheral membrane protein; Cytoplasmic side By similarity HAMAP MF_01357.

Sequence similarities

Belongs to the complex I 30 kDa subunit family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   LigandNAD
Ubiquinone
   Molecular functionOxidoreductase
   PTMQuinone
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processtransport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentplasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionNADH dehydrogenase (ubiquinone) activity

Inferred from electronic annotation. Source: InterPro

quinone binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 197197NADH-quinone oxidoreductase subunit C HAMAP MF_01357
PRO_0000118677

Sequences

Sequence LengthMass (Da)Tools
Q9ZDH3 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 33D79C24C78B4F3E

FASTA19723,279
        10         20         30         40         50         60 
MTLDKLIEKL AAKFRIVITK VAVKDHLAYK IEPHFLLPFL KALKESEELR FTVLTDLFGV 

        70         80         90        100        110        120 
DFPKKEKRFE VVYNLLSLKL NKNLIIKTHI SEKESIPSAM QILSAAYWYE LEVYDMYGVN 

       130        140        150        160        170        180 
FNGNNDKRRI LTDYDFEGHP LRKDFPLTGY TQVKYDKKLE KVTYEPVNLD IEYREFDFSS 

       190 
HWHSPSYVLP GDEKTEE 

« Hide

References

[1]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed: 9823893] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ235271 Genomic DNA. Translation: CAA14815.1.
PIRE71692.
RefSeqNP_220739.1. NC_000963.1.

3D structure databases

ProteinModelPortalQ9ZDH3.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID883378.
GenomeReviewsGene locus RP355 in contig AJ235269_GR.
KEGGrpr:RP355.
PATRIC17901479. VBIRicPro72556_0365.

Phylogenomic databases

HOGENOMHBG727675.
OMALTGYTQV.
ProtClustDBPRK06074.

Enzyme and pathway databases

BioCycRPRO272947:RP355-MONOMER.

Family and domain databases

HAMAPMF_01357. NDH1_NuoC.
[Tree]
InterProIPR010218. NADH_DH_suC.
IPR001268. NADH_UbQ_OxRdtase_30kDa_su.
[Graphical view]
KOK00332.
PfamPF00329. Complex1_30kDa. 1 hit.
[Graphical view]
ProDomPD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR01961. NuoC_fam. 1 hit.
PROSITEPS00542. COMPLEX1_30K. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNUOC_RICPR
AccessionPrimary (citable) accession number: Q9ZDH3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names

SIMILARITY comments

Index of protein domains and families