Reviewed, UniProtKB/Swiss-Prot Q9ZDH3 (NUOC_RICPR)

Names and origin

Protein names

Recommended name:
    NADH-quinone oxidoreductase subunit C
    EC=1.6.99.5
Alternative name(s):
    NADH dehydrogenase I subunit C
    NDH-1 subunit C

Gene names

Name:	nuoC
Ordered Locus Names:	RP355

Organism

Rickettsia prowazekii [Complete proteome] [HAMAP]

Taxonomic identifier

782 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	197 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.
Catalytic activity	NADH + quinone = NAD(+) + quinol.
Sequence similarities	Belongs to the complex I 30 kDa subunit family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
PTM	Quinone
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 197	197	NADH-quinone oxidoreductase subunit C		PRO_0000118677

Sequences

	Sequence		Length	Mass (Da)
	Q9ZDH3-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 33D79C24C78B4F3E	FASTA	197	23,279
	10 20 30 40 50 60 MTLDKLIEKL AAKFRIVITK VAVKDHLAYK IEPHFLLPFL KALKESEELR FTVLTDLFGV 70 80 90 100 110 120 DFPKKEKRFE VVYNLLSLKL NKNLIIKTHI SEKESIPSAM QILSAAYWYE LEVYDMYGVN 130 140 150 160 170 180 FNGNNDKRRI LTDYDFEGHP LRKDFPLTGY TQVKYDKKLE KVTYEPVNLD IEYREFDFSS 190 HWHSPSYVLP GDEKTEE

References

[1]

"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed: 9823893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ235271 Genomic DNA. Translation: CAA14815.1.
PIR	E71692.
RefSeq	NP_220739.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	883378.
GenomeReviews	Gene locus RP355 in contig AJ235269_GR.
KEGG	rpr:RP355.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9ZDH3.
Enzyme and pathway databases
BioCyc	RPRO272947:RP355-MON.
Family and domain databases
InterPro	IPR010218. NADH_DH_csu. IPR001268. NADH_DHase_Ub_30kDa_su. [Graphical view]
Pfam	PF00329. Complex1_30kDa. 1 hit. [Graphical view]
ProDom	PD001581. Complex1_30K. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01961. NuoC_fam. 1 hit.
PROSITE	PS00542. COMPLEX1_30K. False negative. [Graphical view]
BLOCKS	Search...
ProtoNet	Search...

Entry information

Entry name

NUOC_RICPR

Accession

Primary (citable) accession number: Q9ZDH3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	November 4, 2008
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)