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Reviewed, UniProtKB/Swiss-Prot Q9ZDH1 (NUOA_RICPR)

Last modified November 4, 2008. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    NADH-quinone oxidoreductase subunit A
    EC=1.6.99.5
Alternative name(s):
    NADH dehydrogenase I subunit A
    NDH-1 subunit A
Gene names
Name: nuoA
Ordered Locus Names: RP357
OrganismRickettsia prowazekii [Complete proteome] [HAMAP]
Taxonomic identifier782 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length123 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.

Catalytic activity

NADH + quinone = NAD(+) + quinol.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the complex I subunit 3 family.

Ontologies

Keywords

   Cellular componentCell membrane
Membrane
   DomainTransmembrane
   LigandNAD
   Molecular functionOxidoreductase
   PTMQuinone
   Technical termComplete proteome

Gene Ontology (GO)

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionquinone binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 123123NADH-quinone oxidoreductase subunit A
PRO_0000117876

Regions

Transmembrane11 – 3121 Potential
Transmembrane68 – 8821 Potential
Transmembrane93 – 11321 Potential

Sequences

Sequence LengthMass (Da)Tools
Q9ZDH1-1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 39AFA4EEC7E04176

FASTA12314,342
        10         20         30         40         50         60 
MLQNSELLQE YLPIAIFFGI AVLLSVLIMI LPNLLSTKKY NKDKLEPYEC GFEPFSDARS 

        70         80         90        100        110        120 
KFDIRFYLVA ILFIIFDLEI AFLVPWAISL NTIGKMGFFS MMFFLFVLII GFIYEWTKGA 


LDW 

« Hide

References

[1]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed: 9823893] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.

Cross-references

Sequence databases

AJ235271 Genomic DNA. Translation: CAA14817.1.
PIRG71692.
RefSeqNP_220741.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID883383.
GenomeReviewsGene locus RP357 in contig AJ235269_GR.
KEGGrpr:RP357.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ9ZDH1.

Enzyme and pathway databases

BioCycRPRO272947:RP357-MON.

Family and domain databases

InterProIPR000440. Oxidored_q4.
[Graphical view]
PANTHERPTHR11058. Oxidored_q4. 1 hit.
PfamPF00507. Oxidored_q4. 1 hit.
[Graphical view]
BLOCKSSearch...
ProtoNetSearch...

Entry information

Entry nameNUOA_RICPR
AccessionPrimary (citable) accession number: Q9ZDH1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: November 4, 2008
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents