Reviewed,
UniProtKB/Swiss-Prot Q9ZDH1 (NUOA_RICPR)
Last modified
June 16, 2009.
Version 53.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: NADH-quinone oxidoreductase subunit A EC=1.6.99.5 Alternative name(s): NADH dehydrogenase I subunit A NDH-1 subunit A NUO1 | ||||
| Gene names |
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| Organism | Rickettsia prowazekii [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 782 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group |
Protein attributes
| Sequence length | 123 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity. |
| Catalytic activity | NADH + quinone = NAD+ + quinol. HAMAP MF_01394 |
| Subunit structure | NDH-1 is composed of 14 different subunits. Subunits nuoA, H, J, K, L, M, N constitute the membrane sector of the complex By similarity. |
| Subcellular location | Cell inner membrane; Multi-pass membrane protein By similarity. |
| Sequence similarities | Belongs to the complex I subunit 3 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transport |
| Cellular component | Cell inner membrane Cell membrane Membrane |
| Domain | Transmembrane |
| Ligand | NAD Ubiquinone |
| Molecular function | Oxidoreductase |
| PTM | Quinone |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: HAMAP photosynthesis, light reactionInferred from electronic annotation. Source: HAMAP transportInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: InterPro quinone bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 123 | 123 | NADH-quinone oxidoreductase subunit A HAMAP MF_01394 | PRO_0000117876 | |||||
Regions | |||||||||
| Transmembrane | 11 – 31 | 21 | Potential | ||||||
| Transmembrane | 68 – 88 | 21 | Potential | ||||||
| Transmembrane | 93 – 113 | 21 | Potential | ||||||
Sequences
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References
| [1] | "The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed: 9823893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E. |
Cross-references
Sequence databases | |
|---|---|
| AJ235271 Genomic DNA. Translation: CAA14817.1. | |
| PIR | G71692. |
| RefSeq | NP_220741.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 883383. |
| GenomeReviews | Gene locus RP357 in contig AJ235269_GR. |
| KEGG | rpr:RP357. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q9ZDH1. |
| OMA | Q9ZDH1. IGFAYEW. |
Enzyme and pathway databases | |
| BioCyc | RPRO272947:RP357-MON. |
| BRENDA | 1.6.99.5. 141977. |
Family and domain databases | |
| HAMAP | MF_01394. [Tree] |
| InterPro | IPR000440. NADH_UbQ/plastoQ_OxRdtase_su3. [Graphical view] |
| PANTHER | PTHR11058. Oxidored_q4. 1 hit. |
| Pfam | PF00507. Oxidored_q4. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | NUOA_RICPR | ||||||||
| Accession | Primary (citable) accession number: Q9ZDH1 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Rickettsia prowazekii Rickettsia prowazekii (strain Madrid E): entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


