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Q9ZDG4

- FABI_RICPR

UniProt

Q9ZDG4 - FABI_RICPR

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Protein
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
Gene
fabI, RP365
Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism By similarity.

Catalytic activityi

An acyl-[acyl-carrier protein] + NAD+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei15 – 151NAD; via carbonyl oxygen By similarity
Binding sitei42 – 421NAD By similarity
Binding sitei94 – 941NAD; via carbonyl oxygen By similarity
Binding sitei97 – 971Substrate; via amide nitrogen and carbonyl oxygen By similarity
Active sitei147 – 1471Proton acceptor By similarity
Active sitei157 – 1571Proton acceptor By similarity
Binding sitei164 – 1641NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi21 – 222NAD By similarity
Nucleotide bindingi66 – 672NAD By similarity
Nucleotide bindingi193 – 1975NAD By similarity

GO - Molecular functioni

  1. enoyl-[acyl-carrier-protein] reductase (NADH) activity Source: UniProtKB

GO - Biological processi

  1. fatty acid elongation Source: UniProtKB
  2. protein homotetramerization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI (EC:1.3.1.9)
Short name:
ENR
Alternative name(s):
NADH-dependent enoyl-ACP reductase
Gene namesi
Name:fabI
Ordered Locus Names:RP365
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
PRO_0000054909Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

STRINGi272947.RP365.

Structurei

3D structure databases

ProteinModelPortaliQ9ZDG4.
SMRiQ9ZDG4. Positions 4-258.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0623.
KOiK00208.
OMAiGISGEIM.
OrthoDBiEOG6HF644.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR014358. Enoyl-ACP_Rdtase_NADH.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PIRSFiPIRSF000094. Enoyl-ACP_rdct. 1 hit.
PRINTSiPR00081. GDHRDH.

Sequencei

Sequence statusi: Complete.

Q9ZDG4-1 [UniParc]FASTAAdd to Basket

« Hide

MTTGLLQGKK GLITGIANNM SISWAIAQLA KKHGAELWFT YQSEVLEKRV    50
KPLAEEIGCN FISELDVTNQ KSISNLFNDI KEKWNSFDFL LHGMAFANKN 100
ELKGRYVETS LENFHNSLHI SCYSLLELSR SAETLMHNGG SIVTLTYYGA 150
EKVIPNYNIM GVAKAALEAS VKYLANDMGE NNIRVNAISA GPIKTLASSA 200
ISDFSTMLKS HAATAPLKRN ITQEDVGGAA VYLFSELSKG VTGEIHYVDC 250
GYNIIGSSKL L 261
Length:261
Mass (Da):28,538
Last modified:May 1, 1999 - v1
Checksum:i976438A752A8C786
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235271 Genomic DNA. Translation: CAA14824.1.
PIRiF71693.
RefSeqiNP_220748.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA14824; CAA14824; CAA14824.
GeneIDi883278.
KEGGirpr:RP365.
PATRICi17901499. VBIRicPro72556_0374.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235271 Genomic DNA. Translation: CAA14824.1 .
PIRi F71693.
RefSeqi NP_220748.1. NC_000963.1.

3D structure databases

ProteinModelPortali Q9ZDG4.
SMRi Q9ZDG4. Positions 4-258.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272947.RP365.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAA14824 ; CAA14824 ; CAA14824 .
GeneIDi 883278.
KEGGi rpr:RP365.
PATRICi 17901499. VBIRicPro72556_0374.

Phylogenomic databases

eggNOGi COG0623.
KOi K00208.
OMAi GISGEIM.
OrthoDBi EOG6HF644.

Enzyme and pathway databases

UniPathwayi UPA00094 .

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR014358. Enoyl-ACP_Rdtase_NADH.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PIRSFi PIRSF000094. Enoyl-ACP_rdct. 1 hit.
PRINTSi PR00081. GDHRDH.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiFABI_RICPR
AccessioniPrimary (citable) accession number: Q9ZDG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi