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Q9ZDG4

- FABI_RICPR

UniProt

Q9ZDG4 - FABI_RICPR

Protein

Enoyl-[acyl-carrier-protein] reductase [NADH] FabI

Gene

fabI

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism By similarity.By similarity

    Catalytic activityi

    An acyl-[acyl-carrier protein] + NAD+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei15 – 151NAD; via carbonyl oxygenBy similarity
    Binding sitei42 – 421NADBy similarity
    Binding sitei94 – 941NAD; via carbonyl oxygenBy similarity
    Binding sitei97 – 971Substrate; via amide nitrogen and carbonyl oxygenBy similarity
    Active sitei147 – 1471Proton acceptorBy similarity
    Active sitei157 – 1571Proton acceptorBy similarity
    Binding sitei164 – 1641NADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi21 – 222NADBy similarity
    Nucleotide bindingi66 – 672NADBy similarity
    Nucleotide bindingi193 – 1975NADBy similarity

    GO - Molecular functioni

    1. enoyl-[acyl-carrier-protein] reductase (NADH) activity Source: UniProtKB

    GO - Biological processi

    1. fatty acid elongation Source: UniProtKB
    2. protein homotetramerization Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Enoyl-[acyl-carrier-protein] reductase [NADH] FabI (EC:1.3.1.9)
    Short name:
    ENR
    Alternative name(s):
    NADH-dependent enoyl-ACP reductase
    Gene namesi
    Name:fabI
    Ordered Locus Names:RP365
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 261261Enoyl-[acyl-carrier-protein] reductase [NADH] FabIPRO_0000054909Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi272947.RP365.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZDG4.
    SMRiQ9ZDG4. Positions 4-258.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0623.
    KOiK00208.
    OMAiGISGEIM.
    OrthoDBiEOG6HF644.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR014358. Enoyl-ACP_Rdtase_NADH.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PIRSFiPIRSF000094. Enoyl-ACP_rdct. 1 hit.
    PRINTSiPR00081. GDHRDH.

    Sequencei

    Sequence statusi: Complete.

    Q9ZDG4-1 [UniParc]FASTAAdd to Basket

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    MTTGLLQGKK GLITGIANNM SISWAIAQLA KKHGAELWFT YQSEVLEKRV    50
    KPLAEEIGCN FISELDVTNQ KSISNLFNDI KEKWNSFDFL LHGMAFANKN 100
    ELKGRYVETS LENFHNSLHI SCYSLLELSR SAETLMHNGG SIVTLTYYGA 150
    EKVIPNYNIM GVAKAALEAS VKYLANDMGE NNIRVNAISA GPIKTLASSA 200
    ISDFSTMLKS HAATAPLKRN ITQEDVGGAA VYLFSELSKG VTGEIHYVDC 250
    GYNIIGSSKL L 261
    Length:261
    Mass (Da):28,538
    Last modified:May 1, 1999 - v1
    Checksum:i976438A752A8C786
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235271 Genomic DNA. Translation: CAA14824.1.
    PIRiF71693.
    RefSeqiNP_220748.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA14824; CAA14824; CAA14824.
    GeneIDi883278.
    KEGGirpr:RP365.
    PATRICi17901499. VBIRicPro72556_0374.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235271 Genomic DNA. Translation: CAA14824.1 .
    PIRi F71693.
    RefSeqi NP_220748.1. NC_000963.1.

    3D structure databases

    ProteinModelPortali Q9ZDG4.
    SMRi Q9ZDG4. Positions 4-258.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP365.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA14824 ; CAA14824 ; CAA14824 .
    GeneIDi 883278.
    KEGGi rpr:RP365.
    PATRICi 17901499. VBIRicPro72556_0374.

    Phylogenomic databases

    eggNOGi COG0623.
    KOi K00208.
    OMAi GISGEIM.
    OrthoDBi EOG6HF644.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR014358. Enoyl-ACP_Rdtase_NADH.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PIRSFi PIRSF000094. Enoyl-ACP_rdct. 1 hit.
    PRINTSi PR00081. GDHRDH.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.

    Entry informationi

    Entry nameiFABI_RICPR
    AccessioniPrimary (citable) accession number: Q9ZDG4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3