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Q9ZDG4

- FABI_RICPR

UniProt

Q9ZDG4 - FABI_RICPR

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Protein

Enoyl-[acyl-carrier-protein] reductase [NADH] FabI

Gene

fabI

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism By similarity.By similarity

Catalytic activityi

An acyl-[acyl-carrier protein] + NAD+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei15 – 151NAD; via carbonyl oxygenBy similarity
Binding sitei42 – 421NADBy similarity
Binding sitei94 – 941NAD; via carbonyl oxygenBy similarity
Binding sitei97 – 971Substrate; via amide nitrogen and carbonyl oxygenBy similarity
Active sitei147 – 1471Proton acceptorBy similarity
Active sitei157 – 1571Proton acceptorBy similarity
Binding sitei164 – 1641NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi21 – 222NADBy similarity
Nucleotide bindingi66 – 672NADBy similarity
Nucleotide bindingi193 – 1975NADBy similarity

GO - Molecular functioni

  1. enoyl-[acyl-carrier-protein] reductase (NADH) activity Source: UniProtKB

GO - Biological processi

  1. fatty acid elongation Source: UniProtKB
  2. protein homotetramerization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI (EC:1.3.1.9)
Short name:
ENR
Alternative name(s):
NADH-dependent enoyl-ACP reductase
Gene namesi
Name:fabI
Ordered Locus Names:RP365
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Enoyl-[acyl-carrier-protein] reductase [NADH] FabIPRO_0000054909Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi272947.RP365.

Structurei

3D structure databases

ProteinModelPortaliQ9ZDG4.
SMRiQ9ZDG4. Positions 4-258.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0623.
KOiK00208.
OMAiGISGEIM.
OrthoDBiEOG6HF644.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR014358. Enoyl-ACP_Rdtase_NADH.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PIRSFiPIRSF000094. Enoyl-ACP_rdct. 1 hit.
PRINTSiPR00081. GDHRDH.

Sequencei

Sequence statusi: Complete.

Q9ZDG4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTGLLQGKK GLITGIANNM SISWAIAQLA KKHGAELWFT YQSEVLEKRV
60 70 80 90 100
KPLAEEIGCN FISELDVTNQ KSISNLFNDI KEKWNSFDFL LHGMAFANKN
110 120 130 140 150
ELKGRYVETS LENFHNSLHI SCYSLLELSR SAETLMHNGG SIVTLTYYGA
160 170 180 190 200
EKVIPNYNIM GVAKAALEAS VKYLANDMGE NNIRVNAISA GPIKTLASSA
210 220 230 240 250
ISDFSTMLKS HAATAPLKRN ITQEDVGGAA VYLFSELSKG VTGEIHYVDC
260
GYNIIGSSKL L
Length:261
Mass (Da):28,538
Last modified:May 1, 1999 - v1
Checksum:i976438A752A8C786
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235271 Genomic DNA. Translation: CAA14824.1.
PIRiF71693.
RefSeqiNP_220748.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA14824; CAA14824; CAA14824.
GeneIDi883278.
KEGGirpr:RP365.
PATRICi17901499. VBIRicPro72556_0374.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235271 Genomic DNA. Translation: CAA14824.1 .
PIRi F71693.
RefSeqi NP_220748.1. NC_000963.1.

3D structure databases

ProteinModelPortali Q9ZDG4.
SMRi Q9ZDG4. Positions 4-258.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272947.RP365.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAA14824 ; CAA14824 ; CAA14824 .
GeneIDi 883278.
KEGGi rpr:RP365.
PATRICi 17901499. VBIRicPro72556_0374.

Phylogenomic databases

eggNOGi COG0623.
KOi K00208.
OMAi GISGEIM.
OrthoDBi EOG6HF644.

Enzyme and pathway databases

UniPathwayi UPA00094 .

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR014358. Enoyl-ACP_Rdtase_NADH.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PIRSFi PIRSF000094. Enoyl-ACP_rdct. 1 hit.
PRINTSi PR00081. GDHRDH.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiFABI_RICPR
AccessioniPrimary (citable) accession number: Q9ZDG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: October 1, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3