Reviewed, UniProtKB/Swiss-Prot Q9ZDG4 (FABI_RICPR)

Names and origin

Protein names

Recommended name:
    Enoyl-[acyl-carrier-protein] reductase [NADH]
    EC=1.3.1.9
Alternative name(s):
    NADH-dependent enoyl-ACP reductase

Gene names

Name:	fabI
Ordered Locus Names:	RP365

Organism

Rickettsia prowazekii [Complete proteome] [HAMAP]

Taxonomic identifier

782 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Acyl-[acyl-carrier-protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier-protein] + NADH.
Pathway	Lipid metabolism; fatty acid biosynthesis.
Subcellular location	Cell inner membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro enoyl-[acyl-carrier-protein] reductase (NADH) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 261	261	Enoyl-[acyl-carrier-protein] reductase [NADH]		PRO_0000054909
Regions
	Nucleotide binding	12 – 38	27	NAD By similarity
Sites
	Active site	157	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ZDG4-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 976438A752A8C786	FASTA	261	28,538
	10 20 30 40 50 60 MTTGLLQGKK GLITGIANNM SISWAIAQLA KKHGAELWFT YQSEVLEKRV KPLAEEIGCN 70 80 90 100 110 120 FISELDVTNQ KSISNLFNDI KEKWNSFDFL LHGMAFANKN ELKGRYVETS LENFHNSLHI 130 140 150 160 170 180 SCYSLLELSR SAETLMHNGG SIVTLTYYGA EKVIPNYNIM GVAKAALEAS VKYLANDMGE 190 200 210 220 230 240 NNIRVNAISA GPIKTLASSA ISDFSTMLKS HAATAPLKRN ITQEDVGGAA VYLFSELSKG 250 260 VTGEIHYVDC GYNIIGSSKL L

References

[1]

"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed: 9823893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ235271 Genomic DNA. Translation: CAA14824.1.
PIR	F71693.
RefSeq	NP_220748.1.
3D structure databases
HSSP	HSSP built from PDB template 1C14 based on UniProtKB P29132.
ModBase	Search...
Genome annotation databases
GeneID	883278.
GenomeReviews	Gene locus RP365 in contig AJ235269_GR.
KEGG	rpr:RP365.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9ZDG4.
OMA	Q9ZDG4. LVHCLAF.
Enzyme and pathway databases
BioCyc	RPRO272947:RP365-MON.
BRENDA	1.3.1.9. 141977.
Family and domain databases
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR014358. Enoyl-ACP_Rdtase_NADH. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit. PTHR19410:SF12. Enoyl-ACP_rdct. 1 hit.
PRINTS	PR00081. GDHRDH.
ProtoNet	Search...

Entry information

Entry name

FABI_RICPR

Accession

Primary (citable) accession number: Q9ZDG4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	June 16, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)