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Q9ZDF6

- MAO2_RICPR

UniProt

Q9ZDF6 - MAO2_RICPR

Protein

Probable NADP-dependent malic enzyme

Gene

RP373

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-malate + NADP+ = pyruvate + CO2 + NADPH.
    Oxaloacetate = pyruvate + CO2.

    Cofactori

    Divalent metal cations. Prefers magnesium or manganese By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei97 – 971Proton acceptorBy similarity
    Metal bindingi139 – 1391Divalent metal cationBy similarity
    Metal bindingi140 – 1401Divalent metal cationBy similarity
    Binding sitei165 – 1651NADBy similarity
    Binding sitei290 – 2901NADBy similarity

    GO - Molecular functioni

    1. malate dehydrogenase (decarboxylating) (NAD+) activity Source: InterPro
    2. malate dehydrogenase (decarboxylating) (NADP+) activity Source: UniProtKB-EC
    3. manganese ion binding Source: InterPro
    4. NAD binding Source: InterPro
    5. oxaloacetate decarboxylase activity Source: UniProtKB-EC
    6. transferase activity, transferring acyl groups Source: InterPro

    GO - Biological processi

    1. malate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Metal-binding, NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable NADP-dependent malic enzyme (EC:1.1.1.40)
    Short name:
    NADP-ME
    Gene namesi
    Ordered Locus Names:RP373
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 767767Probable NADP-dependent malic enzymePRO_0000160247Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272947.RP373.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZDF6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 430430Malic enzymeAdd
    BLAST
    Regioni431 – 767337Phosphate acetyltransferaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the malic enzymes family.Curated
    In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.Curated

    Phylogenomic databases

    eggNOGiCOG0281.
    HOGENOMiHOG000132448.
    KOiK00029.
    OMAiTFACVEA.
    OrthoDBiEOG6QCD9W.

    Family and domain databases

    Gene3Di3.40.50.10380. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR015884. Malic_enzyme_CS.
    IPR012301. Malic_N_dom.
    IPR012302. Malic_NAD-bd.
    IPR012188. ME_PTA.
    IPR016040. NAD(P)-bd_dom.
    IPR002505. PTA_PTB.
    [Graphical view]
    PfamiPF00390. malic. 1 hit.
    PF03949. Malic_M. 1 hit.
    PF01515. PTA_PTB. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036684. ME_PTA. 1 hit.
    SMARTiSM00919. Malic_M. 1 hit.
    [Graphical view]
    PROSITEiPS00331. MALIC_ENZYMES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZDF6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDEMNKINYT EALEYHEKDK PGKIAITTTK SLVTQQDLSL AYSPGVAAPC    50
    LEISKNLEAV YKYTSRSNLV AVISNGTAVL GLGNLGAAAS KPVMEGKAVL 100
    FKKFADIDAI DLEVNTEDPI EFINAVKYLG YSFGGINLED IKAPECFLIE 150
    EKLKSLMDIP VFHDDQHGTA IITAAGLINA AYLTNRTLKD LKIVINGAGA 200
    AAIACIDLLI ALGVDKSKII LCDTKGVIYK GRTSGMNKWK ERYASDTKIR 250
    TLTESLNNAD VFIGLSVKGA VTKDMISKMA HKPIIFAMAN PDPEITPEDI 300
    KFVRDDAIIA TGRSDYNNQV NNVMGFPYIF RGALDVRAST INTEMKIAAA 350
    RAIADLARRP VPEEVYKAYS GRKMVFGNEY IIPVPFDPRL ITVVATAVAV 400
    AAIESGVARV KDFSIDKYKQ QLGSRLNPTA NYMNFLAEKI HNVPLKRIVF 450
    AEGEEEEVIS AALMMRDEKY GNPIIIGRVE RIEVTLKKIG KDISLAGIQI 500
    MNAALSDRLE QYTDYLYKRL QRKGYLYRDC AKLVKTDKNI FAACMVACGD 550
    GDALLTGVTK SYIDSLEDII KVISPKQNRR ILGYSIMIAK DHNIIIADNC 600
    ITEYPNSLEL AQIATQTAEI AKNMGITPRV ALIAFSTFGN SSQEKTVRIR 650
    EAVNILDNFS KDKKKLNGIK VDFEYDGEMS VKVALDHDLR KLYQFCRLSG 700
    SANVLIMPGL NSAAISTELL QKFSSNSFIG PITNGFAKPV QILPTTATAN 750
    EILKIATFAC VEAIKEV 767
    Length:767
    Mass (Da):84,253
    Last modified:May 1, 1999 - v1
    Checksum:i6782D33C85E30A5E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235271 Genomic DNA. Translation: CAA14832.1.
    PIRiF71694.
    RefSeqiNP_220756.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA14832; CAA14832; CAA14832.
    GeneIDi883450.
    KEGGirpr:RP373.
    PATRICi17901519. VBIRicPro72556_0384.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235271 Genomic DNA. Translation: CAA14832.1 .
    PIRi F71694.
    RefSeqi NP_220756.1. NC_000963.1.

    3D structure databases

    ProteinModelPortali Q9ZDF6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP373.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA14832 ; CAA14832 ; CAA14832 .
    GeneIDi 883450.
    KEGGi rpr:RP373.
    PATRICi 17901519. VBIRicPro72556_0384.

    Phylogenomic databases

    eggNOGi COG0281.
    HOGENOMi HOG000132448.
    KOi K00029.
    OMAi TFACVEA.
    OrthoDBi EOG6QCD9W.

    Family and domain databases

    Gene3Di 3.40.50.10380. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR015884. Malic_enzyme_CS.
    IPR012301. Malic_N_dom.
    IPR012302. Malic_NAD-bd.
    IPR012188. ME_PTA.
    IPR016040. NAD(P)-bd_dom.
    IPR002505. PTA_PTB.
    [Graphical view ]
    Pfami PF00390. malic. 1 hit.
    PF03949. Malic_M. 1 hit.
    PF01515. PTA_PTB. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036684. ME_PTA. 1 hit.
    SMARTi SM00919. Malic_M. 1 hit.
    [Graphical view ]
    PROSITEi PS00331. MALIC_ENZYMES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.

    Entry informationi

    Entry nameiMAO2_RICPR
    AccessioniPrimary (citable) accession number: Q9ZDF6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3