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Q9ZDF6 (MAO2_RICPR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable NADP-dependent malic enzyme

Short name=NADP-ME
EC=1.1.1.40
Gene names
Ordered Locus Names:RP373
OrganismRickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]
Taxonomic identifier272947 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length767 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-malate + NADP+ = pyruvate + CO2 + NADPH.

Oxaloacetate = pyruvate + CO2.

Cofactor

Divalent metal cations. Prefers magnesium or manganese By similarity.

Sequence similarities

In the N-terminal section; belongs to the malic enzymes family.

In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 767767Probable NADP-dependent malic enzyme
PRO_0000160247

Regions

Region1 – 430430Malic enzyme
Region431 – 767337Phosphate acetyltransferase

Sites

Active site971Proton acceptor By similarity
Metal binding1391Divalent metal cation By similarity
Metal binding1401Divalent metal cation By similarity
Binding site1651NAD By similarity
Binding site2901NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ZDF6 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 6782D33C85E30A5E

FASTA76784,253
        10         20         30         40         50         60 
MDEMNKINYT EALEYHEKDK PGKIAITTTK SLVTQQDLSL AYSPGVAAPC LEISKNLEAV 

        70         80         90        100        110        120 
YKYTSRSNLV AVISNGTAVL GLGNLGAAAS KPVMEGKAVL FKKFADIDAI DLEVNTEDPI 

       130        140        150        160        170        180 
EFINAVKYLG YSFGGINLED IKAPECFLIE EKLKSLMDIP VFHDDQHGTA IITAAGLINA 

       190        200        210        220        230        240 
AYLTNRTLKD LKIVINGAGA AAIACIDLLI ALGVDKSKII LCDTKGVIYK GRTSGMNKWK 

       250        260        270        280        290        300 
ERYASDTKIR TLTESLNNAD VFIGLSVKGA VTKDMISKMA HKPIIFAMAN PDPEITPEDI 

       310        320        330        340        350        360 
KFVRDDAIIA TGRSDYNNQV NNVMGFPYIF RGALDVRAST INTEMKIAAA RAIADLARRP 

       370        380        390        400        410        420 
VPEEVYKAYS GRKMVFGNEY IIPVPFDPRL ITVVATAVAV AAIESGVARV KDFSIDKYKQ 

       430        440        450        460        470        480 
QLGSRLNPTA NYMNFLAEKI HNVPLKRIVF AEGEEEEVIS AALMMRDEKY GNPIIIGRVE 

       490        500        510        520        530        540 
RIEVTLKKIG KDISLAGIQI MNAALSDRLE QYTDYLYKRL QRKGYLYRDC AKLVKTDKNI 

       550        560        570        580        590        600 
FAACMVACGD GDALLTGVTK SYIDSLEDII KVISPKQNRR ILGYSIMIAK DHNIIIADNC 

       610        620        630        640        650        660 
ITEYPNSLEL AQIATQTAEI AKNMGITPRV ALIAFSTFGN SSQEKTVRIR EAVNILDNFS 

       670        680        690        700        710        720 
KDKKKLNGIK VDFEYDGEMS VKVALDHDLR KLYQFCRLSG SANVLIMPGL NSAAISTELL 

       730        740        750        760 
QKFSSNSFIG PITNGFAKPV QILPTTATAN EILKIATFAC VEAIKEV 

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References

[1]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ235271 Genomic DNA. Translation: CAA14832.1.
PIRF71694.
RefSeqNP_220756.1. NC_000963.1.

3D structure databases

ProteinModelPortalQ9ZDF6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272947.RP373.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAA14832; CAA14832; CAA14832.
GeneID883450.
KEGGrpr:RP373.
PATRIC17901519. VBIRicPro72556_0384.

Phylogenomic databases

eggNOGCOG0281.
HOGENOMHOG000132448.
KOK00029.
OMATFACVEA.
OrthoDBEOG6QCD9W.

Family and domain databases

Gene3D3.40.50.10380. 1 hit.
3.40.50.720. 1 hit.
InterProIPR015884. Malic_enzyme_CS.
IPR012301. Malic_N_dom.
IPR012302. Malic_NAD-bd.
IPR012188. ME_PTA.
IPR016040. NAD(P)-bd_dom.
IPR002505. PTA_PTB.
[Graphical view]
PfamPF00390. malic. 1 hit.
PF03949. Malic_M. 1 hit.
PF01515. PTA_PTB. 1 hit.
[Graphical view]
PIRSFPIRSF036684. ME_PTA. 1 hit.
SMARTSM00919. Malic_M. 1 hit.
[Graphical view]
PROSITEPS00331. MALIC_ENZYMES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMAO2_RICPR
AccessionPrimary (citable) accession number: Q9ZDF6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names