Q9ZDC6 (COX2_RICPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable cytochrome c oxidase subunit 2
EC=1.9.3.1

Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II

Gene names

Name:	ctaC
Synonyms:	coxB
Ordered Locus Names:	RP406

Organism

Rickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]

Taxonomic identifier

272947 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group › Rickettsia prowazekii

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) By similarity.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Cofactor	Copper A By similarity. Heme group By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 2 family. Contains 1 RPE1 insert domain.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Copper Heme Iron Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 313	313	Probable cytochrome c oxidase subunit 2		PRO_0000183720
Regions
	Transmembrane	39 – 59	21	Helical; Potential
	Transmembrane	94 – 114	21	Helical; Potential
	Transmembrane	131 – 151	21	Helical; Potential
	Domain	5 – 51	47	RPE1 insert
Sites
	Metal binding	233	1	Copper A Potential
	Metal binding	268	1	Copper A Potential
	Metal binding	272	1	Copper A Potential
	Metal binding	276	1	Copper A Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9ZDC6 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 77CD4D8F6A4201E5	FASTA	313	36,037
	10 20 30 40 50 60 MNIIRYWSKQ SYKKLKVDQE HNTTEYTNVC NSTSLGSTYT LPLKMELWKI YITLIYFLIT 70 80 90 100 110 120 NSNCFASEPL AWQITFQPPA SPIMEELYHF HNFLLYIGTA IVLFVAGLLG FVCIRFNAKN 130 140 150 160 170 180 NPVPAKFAHN LLIEIIWTVI PIIILVIIAV PSFRILRHAE KIPEIDLTIK VVGYQWYWHY 190 200 210 220 230 240 IYPDYDNLEF DSVMISDKNL QIGQKRLLDV DNRIVIPENT TVRFLITAGD VIHSFAVPSL 250 260 270 280 290 300 GFKIDAVPGR INETWTRVTK KGVYYGQCSE LCGINHGFMP IAIEVVSKED FNNWIALKNK 310 TAMNNKSSKL MSK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.
[2]	"Selfish DNA in protein-coding genes of Rickettsia." Ogata H., Audic S., Barbe V., Artiguenave F., Fournier P.-E., Raoult D., Claverie J.-M. Science 290:347-350(2000) [PubMed] [Europe PMC] [Abstract] Cited for: DOMAIN RPE1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ235271 Genomic DNA. Translation: CAA14863.1.
PIR	E71698.
RefSeq	NP_220787.1. NC_000963.1.
3D structure databases
ProteinModelPortal	Q9ZDC6.
ModBase	Search...
Protein-protein interaction databases
STRING	272947.RP406.
Proteomic databases
PRIDE	Q9ZDC6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAA14863; CAA14863; CAA14863.
GeneID	883399.
KEGG	rpr:RP406.
PATRIC	17901593. VBIRicPro72556_0419.
Phylogenomic databases
eggNOG	COG1622.
HOGENOM	HOG000264988.
KO	K02275.
OMA	LIEVAWT.
ProtClustDB	CLSK870908.
Family and domain databases
Gene3D	1.10.287.90. 1 hit. 2.60.40.420. 1 hit.
InterPro	IPR001505. Copper_CuA. IPR008972. Cupredoxin. IPR014222. Cyt_c_oxidase_su2. IPR002429. Cyt_c_oxidase_su2_C. IPR011759. Cyt_c_oxidase_su2_TM_dom. IPR005728. Rickett_RPE. [Graphical view]
Pfam	PF00116. COX2. 1 hit. PF02790. COX2_TM. 1 hit. [Graphical view]
SUPFAM	SSF49503. Cupredoxin. 1 hit. SSF81464. Cyt_c_oxidase_II-like_TM. 1 hit.
TIGRFAMs	TIGR02866. CoxB. 1 hit. TIGR01045. RPE1. 1 hit.
PROSITE	PS00078. COX2. 1 hit. PS50857. COX2_CUA. 1 hit. PS50999. COX2_TM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX2_RICPR

Accession

Primary (citable) accession number: Q9ZDC6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program