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Q9ZDC6

- COX2_RICPR

UniProt

Q9ZDC6 - COX2_RICPR

Protein

Probable cytochrome c oxidase subunit 2

Gene

ctaC

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) By similarity.By similarity

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Copper A.By similarity
    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi233 – 2331Copper ASequence Analysis
    Metal bindingi268 – 2681Copper ASequence Analysis
    Metal bindingi272 – 2721Copper ASequence Analysis
    Metal bindingi276 – 2761Copper ASequence Analysis

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome aa3 subunit 2
    Cytochrome c oxidase polypeptide II
    Gene namesi
    Name:ctaC
    Synonyms:coxB
    Ordered Locus Names:RP406
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 313313Probable cytochrome c oxidase subunit 2PRO_0000183720Add
    BLAST

    Proteomic databases

    PRIDEiQ9ZDC6.

    Interactioni

    Protein-protein interaction databases

    STRINGi272947.RP406.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZDC6.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei39 – 5921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei94 – 11421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei131 – 15121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 5147RPE1 insertAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RPE1 insert domain.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1622.
    HOGENOMiHOG000264988.
    KOiK02275.
    OMAiTSIMLTD.
    OrthoDBiEOG68SVXT.

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    IPR005728. Rickett_RPE.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsiTIGR02866. CoxB. 1 hit.
    TIGR01045. RPE1. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZDC6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNIIRYWSKQ SYKKLKVDQE HNTTEYTNVC NSTSLGSTYT LPLKMELWKI    50
    YITLIYFLIT NSNCFASEPL AWQITFQPPA SPIMEELYHF HNFLLYIGTA 100
    IVLFVAGLLG FVCIRFNAKN NPVPAKFAHN LLIEIIWTVI PIIILVIIAV 150
    PSFRILRHAE KIPEIDLTIK VVGYQWYWHY IYPDYDNLEF DSVMISDKNL 200
    QIGQKRLLDV DNRIVIPENT TVRFLITAGD VIHSFAVPSL GFKIDAVPGR 250
    INETWTRVTK KGVYYGQCSE LCGINHGFMP IAIEVVSKED FNNWIALKNK 300
    TAMNNKSSKL MSK 313
    Length:313
    Mass (Da):36,037
    Last modified:May 1, 1999 - v1
    Checksum:i77CD4D8F6A4201E5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235271 Genomic DNA. Translation: CAA14863.1.
    PIRiE71698.
    RefSeqiNP_220787.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA14863; CAA14863; CAA14863.
    GeneIDi883399.
    KEGGirpr:RP406.
    PATRICi17901593. VBIRicPro72556_0419.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235271 Genomic DNA. Translation: CAA14863.1 .
    PIRi E71698.
    RefSeqi NP_220787.1. NC_000963.1.

    3D structure databases

    ProteinModelPortali Q9ZDC6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP406.

    Proteomic databases

    PRIDEi Q9ZDC6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA14863 ; CAA14863 ; CAA14863 .
    GeneIDi 883399.
    KEGGi rpr:RP406.
    PATRICi 17901593. VBIRicPro72556_0419.

    Phylogenomic databases

    eggNOGi COG1622.
    HOGENOMi HOG000264988.
    KOi K02275.
    OMAi TSIMLTD.
    OrthoDBi EOG68SVXT.

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    IPR005728. Rickett_RPE.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsi TIGR02866. CoxB. 1 hit.
    TIGR01045. RPE1. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.
    2. Cited for: DOMAIN RPE1.

    Entry informationi

    Entry nameiCOX2_RICPR
    AccessioniPrimary (citable) accession number: Q9ZDC6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3