Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9ZDC6 (COX2_RICPR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Gene names
Name:ctaC
Synonyms:coxB
Ordered Locus Names:RP406
OrganismRickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]
Taxonomic identifier272947 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) By similarity.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A By similarity.

Heme group By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Contains 1 RPE1 insert domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 313313Probable cytochrome c oxidase subunit 2
PRO_0000183720

Regions

Transmembrane39 – 5921Helical; Potential
Transmembrane94 – 11421Helical; Potential
Transmembrane131 – 15121Helical; Potential
Domain5 – 5147RPE1 insert

Sites

Metal binding2331Copper A Potential
Metal binding2681Copper A Potential
Metal binding2721Copper A Potential
Metal binding2761Copper A Potential

Sequences

Sequence LengthMass (Da)Tools
Q9ZDC6 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 77CD4D8F6A4201E5

FASTA31336,037
        10         20         30         40         50         60 
MNIIRYWSKQ SYKKLKVDQE HNTTEYTNVC NSTSLGSTYT LPLKMELWKI YITLIYFLIT 

        70         80         90        100        110        120 
NSNCFASEPL AWQITFQPPA SPIMEELYHF HNFLLYIGTA IVLFVAGLLG FVCIRFNAKN 

       130        140        150        160        170        180 
NPVPAKFAHN LLIEIIWTVI PIIILVIIAV PSFRILRHAE KIPEIDLTIK VVGYQWYWHY 

       190        200        210        220        230        240 
IYPDYDNLEF DSVMISDKNL QIGQKRLLDV DNRIVIPENT TVRFLITAGD VIHSFAVPSL 

       250        260        270        280        290        300 
GFKIDAVPGR INETWTRVTK KGVYYGQCSE LCGINHGFMP IAIEVVSKED FNNWIALKNK 

       310 
TAMNNKSSKL MSK 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.
[2]"Selfish DNA in protein-coding genes of Rickettsia."
Ogata H., Audic S., Barbe V., Artiguenave F., Fournier P.-E., Raoult D., Claverie J.-M.
Science 290:347-350(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: DOMAIN RPE1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ235271 Genomic DNA. Translation: CAA14863.1.
PIRE71698.
RefSeqNP_220787.1. NC_000963.1.

3D structure databases

ProteinModelPortalQ9ZDC6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272947.RP406.

Proteomic databases

PRIDEQ9ZDC6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAA14863; CAA14863; CAA14863.
GeneID883399.
KEGGrpr:RP406.
PATRIC17901593. VBIRicPro72556_0419.

Phylogenomic databases

eggNOGCOG1622.
HOGENOMHOG000264988.
KOK02275.
OMAFMPIAIR.
OrthoDBEOG68SVXT.
ProtClustDBCLSK870908.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
IPR005728. Rickett_RPE.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
TIGR01045. RPE1. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_RICPR
AccessionPrimary (citable) accession number: Q9ZDC6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names