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Protein

Probable cytochrome c oxidase subunit 2

Gene

ctaC

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity).By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • Cu cationBy similarityNote: Binds a copper A center.By similarity
  • hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi233Copper ASequence analysis1
Metal bindingi268Copper ASequence analysis1
Metal bindingi272Copper ASequence analysis1
Metal bindingi276Copper ASequence analysis1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciRPRO272947:G1GT0-408-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Gene namesi
Name:ctaC
Synonyms:coxB
Ordered Locus Names:RP406
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000002480 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001837201 – 313Probable cytochrome c oxidase subunit 2Add BLAST313

Proteomic databases

PRIDEiQ9ZDC6

Interactioni

Protein-protein interaction databases

STRINGi272947.RP406

Structurei

3D structure databases

ProteinModelPortaliQ9ZDC6
SMRiQ9ZDC6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 51RPE1 insertAdd BLAST47

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CV4 Bacteria
COG1622 LUCA
HOGENOMiHOG000264988
KOiK02275
OMAiHAFMPIA

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
IPR005728 Rickett_RPE
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
TIGR01045 RPE1, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ZDC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIIRYWSKQ SYKKLKVDQE HNTTEYTNVC NSTSLGSTYT LPLKMELWKI
60 70 80 90 100
YITLIYFLIT NSNCFASEPL AWQITFQPPA SPIMEELYHF HNFLLYIGTA
110 120 130 140 150
IVLFVAGLLG FVCIRFNAKN NPVPAKFAHN LLIEIIWTVI PIIILVIIAV
160 170 180 190 200
PSFRILRHAE KIPEIDLTIK VVGYQWYWHY IYPDYDNLEF DSVMISDKNL
210 220 230 240 250
QIGQKRLLDV DNRIVIPENT TVRFLITAGD VIHSFAVPSL GFKIDAVPGR
260 270 280 290 300
INETWTRVTK KGVYYGQCSE LCGINHGFMP IAIEVVSKED FNNWIALKNK
310
TAMNNKSSKL MSK
Length:313
Mass (Da):36,037
Last modified:May 1, 1999 - v1
Checksum:i77CD4D8F6A4201E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235271 Genomic DNA Translation: CAA14863.1
PIRiE71698
RefSeqiNP_220787.1, NC_000963.1
WP_010886286.1, NC_000963.1

Genome annotation databases

EnsemblBacteriaiCAA14863; CAA14863; CAA14863
GeneIDi883399
KEGGirpr:RP406
PATRICifig|272947.5.peg.419

Similar proteinsi

Entry informationi

Entry nameiCOX2_RICPR
AccessioniPrimary (citable) accession number: Q9ZDC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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