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Q9ZDC6

- COX2_RICPR

UniProt

Q9ZDC6 - COX2_RICPR

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Protein
Probable cytochrome c oxidase subunit 2
Gene
ctaC, coxB, RP406
Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) By similarity.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A By similarity.
Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi233 – 2331Copper A Reviewed prediction
Metal bindingi268 – 2681Copper A Reviewed prediction
Metal bindingi272 – 2721Copper A Reviewed prediction
Metal bindingi276 – 2761Copper A Reviewed prediction

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Gene namesi
Name:ctaC
Synonyms:coxB
Ordered Locus Names:RP406
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei39 – 5921Helical; Reviewed prediction
Add
BLAST
Transmembranei94 – 11421Helical; Reviewed prediction
Add
BLAST
Transmembranei131 – 15121Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Probable cytochrome c oxidase subunit 2
PRO_0000183720Add
BLAST

Proteomic databases

PRIDEiQ9ZDC6.

Interactioni

Protein-protein interaction databases

STRINGi272947.RP406.

Structurei

3D structure databases

ProteinModelPortaliQ9ZDC6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 5147RPE1 insert
Add
BLAST

Sequence similaritiesi

Contains 1 RPE1 insert domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1622.
HOGENOMiHOG000264988.
KOiK02275.
OMAiTSIMLTD.
OrthoDBiEOG68SVXT.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
IPR005728. Rickett_RPE.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
TIGR01045. RPE1. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZDC6-1 [UniParc]FASTAAdd to Basket

« Hide

MNIIRYWSKQ SYKKLKVDQE HNTTEYTNVC NSTSLGSTYT LPLKMELWKI    50
YITLIYFLIT NSNCFASEPL AWQITFQPPA SPIMEELYHF HNFLLYIGTA 100
IVLFVAGLLG FVCIRFNAKN NPVPAKFAHN LLIEIIWTVI PIIILVIIAV 150
PSFRILRHAE KIPEIDLTIK VVGYQWYWHY IYPDYDNLEF DSVMISDKNL 200
QIGQKRLLDV DNRIVIPENT TVRFLITAGD VIHSFAVPSL GFKIDAVPGR 250
INETWTRVTK KGVYYGQCSE LCGINHGFMP IAIEVVSKED FNNWIALKNK 300
TAMNNKSSKL MSK 313
Length:313
Mass (Da):36,037
Last modified:May 1, 1999 - v1
Checksum:i77CD4D8F6A4201E5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235271 Genomic DNA. Translation: CAA14863.1.
PIRiE71698.
RefSeqiNP_220787.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA14863; CAA14863; CAA14863.
GeneIDi883399.
KEGGirpr:RP406.
PATRICi17901593. VBIRicPro72556_0419.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235271 Genomic DNA. Translation: CAA14863.1 .
PIRi E71698.
RefSeqi NP_220787.1. NC_000963.1.

3D structure databases

ProteinModelPortali Q9ZDC6.
ModBasei Search...

Protein-protein interaction databases

STRINGi 272947.RP406.

Proteomic databases

PRIDEi Q9ZDC6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAA14863 ; CAA14863 ; CAA14863 .
GeneIDi 883399.
KEGGi rpr:RP406.
PATRICi 17901593. VBIRicPro72556_0419.

Phylogenomic databases

eggNOGi COG1622.
HOGENOMi HOG000264988.
KOi K02275.
OMAi TSIMLTD.
OrthoDBi EOG68SVXT.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
IPR005728. Rickett_RPE.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
TIGR01045. RPE1. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.
  2. Cited for: DOMAIN RPE1.

Entry informationi

Entry nameiCOX2_RICPR
AccessioniPrimary (citable) accession number: Q9ZDC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi