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Q9ZDB4

- SYFB_RICPR

UniProt

Q9ZDB4 - SYFB_RICPR

Protein

Phenylalanine--tRNA ligase beta subunit

Gene

pheT

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).

    Cofactori

    Binds 2 magnesium ions per tetramer.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi474 – 4741MagnesiumBy similarity
    Metal bindingi480 – 4801Magnesium; via carbonyl oxygenBy similarity
    Metal bindingi483 – 4831MagnesiumBy similarity
    Metal bindingi484 – 4841MagnesiumBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. phenylalanine-tRNA ligase activity Source: UniProtKB-HAMAP
    4. tRNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. phenylalanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
    2. tRNA processing Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, RNA-binding, tRNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phenylalanine--tRNA ligase beta subunit (EC:6.1.1.20)
    Alternative name(s):
    Phenylalanyl-tRNA synthetase beta subunit
    Short name:
    PheRS
    Gene namesi
    Name:pheT
    Ordered Locus Names:RP418
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 815815Phenylalanine--tRNA ligase beta subunitPRO_0000126940Add
    BLAST

    Interactioni

    Subunit structurei

    Tetramer of two alpha and two beta subunits.By similarity

    Protein-protein interaction databases

    STRINGi272947.RP418.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZDB4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini39 – 148110tRNA-bindingAdd
    BLAST
    Domaini421 – 49676B5Add
    BLAST
    Domaini721 – 81494FDX-ACBAdd
    BLAST

    Sequence similaritiesi

    Contains 1 B5 domain.Curated
    Contains 1 FDX-ACB domain.Curated
    Contains 1 tRNA-binding domain.Curated

    Phylogenomic databases

    eggNOGiCOG0073.
    HOGENOMiHOG000292085.
    KOiK01890.
    OMAiNYVMIEL.
    OrthoDBiEOG6CCH1J.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    3.30.56.20. 1 hit.
    3.30.70.380. 1 hit.
    3.50.40.10. 1 hit.
    HAMAPiMF_00283. Phe_tRNA_synth_beta1.
    InterProiIPR005146. B3/B4_tRNA-bd.
    IPR009061. DNA-bd_dom_put.
    IPR012340. NA-bd_OB-fold.
    IPR004532. Phe-tRNA-ligase_IIc_bsu.
    IPR020825. Phe-tRNA_synthase_B3/B4.
    IPR005121. PheS_beta_Fdx_antiC-bd.
    IPR002547. tRNA-bd_dom.
    IPR005147. tRNA_synthase_B5-dom.
    [Graphical view]
    PfamiPF03483. B3_4. 1 hit.
    PF03484. B5. 1 hit.
    PF03147. FDX-ACB. 1 hit.
    PF01588. tRNA_bind. 1 hit.
    [Graphical view]
    SMARTiSM00873. B3_4. 1 hit.
    SM00874. B5. 1 hit.
    SM00896. FDX-ACB. 1 hit.
    [Graphical view]
    SUPFAMiSSF46955. SSF46955. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54991. SSF54991. 1 hit.
    SSF56037. SSF56037. 1 hit.
    TIGRFAMsiTIGR00472. pheT_bact. 1 hit.
    PROSITEiPS51483. B5. 1 hit.
    PS51447. FDX_ACB. 1 hit.
    PS50886. TRBD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZDB4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFTLSWLKQ FLEISASVTE IAEALTDIGL EVEEVIDKSK ELQKFEVAYI    50
    RNIKPHPSAD KLKLCDVETK NGILQIVCGA SNVRADIKVV LANIGIEIPK 100
    GNLKIKESVI RGQKSYGMLC SEEELLLSSN SDGIIELPKD AVVGDNFTKY 150
    YGLDDPIFVI NVTPNRGDVL GVYGIARDLS AKGLGTLKEL ELSEIKSTFF 200
    SKIKLNVHDK EACPLFTFRE IRNLKNKPSP NWLQQLLKNV GIKTISSLVD 250
    VTNYISHSFG QPIHAYDADK IYGGISVDCY IRSDKVISCK NHEMATAVLQ 300
    FSNDSANFYA INGKGYLLTE NDLAIKDESG IQGLAGIIGG AKSSCNDSTT 350
    NVILEAACFN AKMVAASGRR LKIDTDARYR NERNIDRNFT EKALNIATNL 400
    ILSICGNCEV SEVVKVGEQE PQKKPLDFSV YFLEKITGIK LSIQEIEDIL 450
    NKLGFITDVK GDIIKVIAPS WRHDINILED IAEEIVRIYG YDKIESIKLP 500
    ELYQNNNLRE YKRISSFKRI LASKGYDEVV TNSFMSSEDA KLFAELKEGL 550
    FLLNPMSIEE NYMRPTVLPN LISIVSKNLA RDVKDMAFFE VGPSFVNLNI 600
    ESTYLTAIIS GAFNNKNPHS FGRNYDIFDI KGDLEQVIEY AGLSLDKCIV 650
    IDETVLPQYY HPTRAINIRL GKNLLGHFGQ IHPKILKYYD INQEIFAFEL 700
    NITNLPLIKA KFGKRDEFTV SDYQANFRDY SFIVDQDHKV GEIISYIKNF 750
    NKKLVKSVML FDIYSGDKLP EGKKSIAIKI KLQADDRTLS ETDLNSFSED 800
    LVASISQKFQ GILRE 815
    Length:815
    Mass (Da):91,585
    Last modified:May 1, 1999 - v1
    Checksum:iF508E95333FCAE43
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235271 Genomic DNA. Translation: CAA14875.1.
    PIRiA71700.
    RefSeqiNP_220799.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA14875; CAA14875; CAA14875.
    GeneIDi883323.
    KEGGirpr:RP418.
    PATRICi17901617. VBIRicPro72556_0431.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235271 Genomic DNA. Translation: CAA14875.1 .
    PIRi A71700.
    RefSeqi NP_220799.1. NC_000963.1.

    3D structure databases

    ProteinModelPortali Q9ZDB4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP418.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA14875 ; CAA14875 ; CAA14875 .
    GeneIDi 883323.
    KEGGi rpr:RP418.
    PATRICi 17901617. VBIRicPro72556_0431.

    Phylogenomic databases

    eggNOGi COG0073.
    HOGENOMi HOG000292085.
    KOi K01890.
    OMAi NYVMIEL.
    OrthoDBi EOG6CCH1J.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    3.30.56.20. 1 hit.
    3.30.70.380. 1 hit.
    3.50.40.10. 1 hit.
    HAMAPi MF_00283. Phe_tRNA_synth_beta1.
    InterProi IPR005146. B3/B4_tRNA-bd.
    IPR009061. DNA-bd_dom_put.
    IPR012340. NA-bd_OB-fold.
    IPR004532. Phe-tRNA-ligase_IIc_bsu.
    IPR020825. Phe-tRNA_synthase_B3/B4.
    IPR005121. PheS_beta_Fdx_antiC-bd.
    IPR002547. tRNA-bd_dom.
    IPR005147. tRNA_synthase_B5-dom.
    [Graphical view ]
    Pfami PF03483. B3_4. 1 hit.
    PF03484. B5. 1 hit.
    PF03147. FDX-ACB. 1 hit.
    PF01588. tRNA_bind. 1 hit.
    [Graphical view ]
    SMARTi SM00873. B3_4. 1 hit.
    SM00874. B5. 1 hit.
    SM00896. FDX-ACB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46955. SSF46955. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54991. SSF54991. 1 hit.
    SSF56037. SSF56037. 1 hit.
    TIGRFAMsi TIGR00472. pheT_bact. 1 hit.
    PROSITEi PS51483. B5. 1 hit.
    PS51447. FDX_ACB. 1 hit.
    PS50886. TRBD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.

    Entry informationi

    Entry nameiSYFB_RICPR
    AccessioniPrimary (citable) accession number: Q9ZDB4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3