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Q9ZDB4

- SYFB_RICPR

UniProt

Q9ZDB4 - SYFB_RICPR

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Protein

Phenylalanine--tRNA ligase beta subunit

Gene
pheT, RP418
Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).UniRule annotation

Cofactori

Binds 2 magnesium ions per tetramer By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi474 – 4741Magnesium By similarity
Metal bindingi480 – 4801Magnesium; via carbonyl oxygen By similarity
Metal bindingi483 – 4831Magnesium By similarity
Metal bindingi484 – 4841Magnesium By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. phenylalanine-tRNA ligase activity Source: UniProtKB-HAMAP
  4. tRNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. phenylalanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
  2. tRNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, RNA-binding, tRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phenylalanine--tRNA ligase beta subunit (EC:6.1.1.20)
Alternative name(s):
Phenylalanyl-tRNA synthetase beta subunit
Short name:
PheRS
Gene namesi
Name:pheT
Ordered Locus Names:RP418
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 815815Phenylalanine--tRNA ligase beta subunitUniRule annotationPRO_0000126940Add
BLAST

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits By similarity.

Protein-protein interaction databases

STRINGi272947.RP418.

Structurei

3D structure databases

ProteinModelPortaliQ9ZDB4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 148110tRNA-bindingAdd
BLAST
Domaini421 – 49676B5Add
BLAST
Domaini721 – 81494FDX-ACBAdd
BLAST

Sequence similaritiesi

Contains 1 B5 domain.
Contains 1 FDX-ACB domain.

Phylogenomic databases

eggNOGiCOG0073.
HOGENOMiHOG000292085.
KOiK01890.
OMAiNYVMIEL.
OrthoDBiEOG6CCH1J.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
3.30.56.20. 1 hit.
3.30.70.380. 1 hit.
3.50.40.10. 1 hit.
HAMAPiMF_00283. Phe_tRNA_synth_beta1.
InterProiIPR005146. B3/B4_tRNA-bd.
IPR009061. DNA-bd_dom_put.
IPR012340. NA-bd_OB-fold.
IPR004532. Phe-tRNA-ligase_IIc_bsu.
IPR020825. Phe-tRNA_synthase_B3/B4.
IPR005121. PheS_beta_Fdx_antiC-bd.
IPR002547. tRNA-bd_dom.
IPR005147. tRNA_synthase_B5-dom.
[Graphical view]
PfamiPF03483. B3_4. 1 hit.
PF03484. B5. 1 hit.
PF03147. FDX-ACB. 1 hit.
PF01588. tRNA_bind. 1 hit.
[Graphical view]
SMARTiSM00873. B3_4. 1 hit.
SM00874. B5. 1 hit.
SM00896. FDX-ACB. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54991. SSF54991. 1 hit.
SSF56037. SSF56037. 1 hit.
TIGRFAMsiTIGR00472. pheT_bact. 1 hit.
PROSITEiPS51483. B5. 1 hit.
PS51447. FDX_ACB. 1 hit.
PS50886. TRBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZDB4-1 [UniParc]FASTAAdd to Basket

« Hide

MKFTLSWLKQ FLEISASVTE IAEALTDIGL EVEEVIDKSK ELQKFEVAYI    50
RNIKPHPSAD KLKLCDVETK NGILQIVCGA SNVRADIKVV LANIGIEIPK 100
GNLKIKESVI RGQKSYGMLC SEEELLLSSN SDGIIELPKD AVVGDNFTKY 150
YGLDDPIFVI NVTPNRGDVL GVYGIARDLS AKGLGTLKEL ELSEIKSTFF 200
SKIKLNVHDK EACPLFTFRE IRNLKNKPSP NWLQQLLKNV GIKTISSLVD 250
VTNYISHSFG QPIHAYDADK IYGGISVDCY IRSDKVISCK NHEMATAVLQ 300
FSNDSANFYA INGKGYLLTE NDLAIKDESG IQGLAGIIGG AKSSCNDSTT 350
NVILEAACFN AKMVAASGRR LKIDTDARYR NERNIDRNFT EKALNIATNL 400
ILSICGNCEV SEVVKVGEQE PQKKPLDFSV YFLEKITGIK LSIQEIEDIL 450
NKLGFITDVK GDIIKVIAPS WRHDINILED IAEEIVRIYG YDKIESIKLP 500
ELYQNNNLRE YKRISSFKRI LASKGYDEVV TNSFMSSEDA KLFAELKEGL 550
FLLNPMSIEE NYMRPTVLPN LISIVSKNLA RDVKDMAFFE VGPSFVNLNI 600
ESTYLTAIIS GAFNNKNPHS FGRNYDIFDI KGDLEQVIEY AGLSLDKCIV 650
IDETVLPQYY HPTRAINIRL GKNLLGHFGQ IHPKILKYYD INQEIFAFEL 700
NITNLPLIKA KFGKRDEFTV SDYQANFRDY SFIVDQDHKV GEIISYIKNF 750
NKKLVKSVML FDIYSGDKLP EGKKSIAIKI KLQADDRTLS ETDLNSFSED 800
LVASISQKFQ GILRE 815
Length:815
Mass (Da):91,585
Last modified:May 1, 1999 - v1
Checksum:iF508E95333FCAE43
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235271 Genomic DNA. Translation: CAA14875.1.
PIRiA71700.
RefSeqiNP_220799.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA14875; CAA14875; CAA14875.
GeneIDi883323.
KEGGirpr:RP418.
PATRICi17901617. VBIRicPro72556_0431.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235271 Genomic DNA. Translation: CAA14875.1 .
PIRi A71700.
RefSeqi NP_220799.1. NC_000963.1.

3D structure databases

ProteinModelPortali Q9ZDB4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272947.RP418.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAA14875 ; CAA14875 ; CAA14875 .
GeneIDi 883323.
KEGGi rpr:RP418.
PATRICi 17901617. VBIRicPro72556_0431.

Phylogenomic databases

eggNOGi COG0073.
HOGENOMi HOG000292085.
KOi K01890.
OMAi NYVMIEL.
OrthoDBi EOG6CCH1J.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
3.30.56.20. 1 hit.
3.30.70.380. 1 hit.
3.50.40.10. 1 hit.
HAMAPi MF_00283. Phe_tRNA_synth_beta1.
InterProi IPR005146. B3/B4_tRNA-bd.
IPR009061. DNA-bd_dom_put.
IPR012340. NA-bd_OB-fold.
IPR004532. Phe-tRNA-ligase_IIc_bsu.
IPR020825. Phe-tRNA_synthase_B3/B4.
IPR005121. PheS_beta_Fdx_antiC-bd.
IPR002547. tRNA-bd_dom.
IPR005147. tRNA_synthase_B5-dom.
[Graphical view ]
Pfami PF03483. B3_4. 1 hit.
PF03484. B5. 1 hit.
PF03147. FDX-ACB. 1 hit.
PF01588. tRNA_bind. 1 hit.
[Graphical view ]
SMARTi SM00873. B3_4. 1 hit.
SM00874. B5. 1 hit.
SM00896. FDX-ACB. 1 hit.
[Graphical view ]
SUPFAMi SSF46955. SSF46955. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54991. SSF54991. 1 hit.
SSF56037. SSF56037. 1 hit.
TIGRFAMsi TIGR00472. pheT_bact. 1 hit.
PROSITEi PS51483. B5. 1 hit.
PS51447. FDX_ACB. 1 hit.
PS50886. TRBD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiSYFB_RICPR
AccessioniPrimary (citable) accession number: Q9ZDB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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