SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9ZDB1

- SYL_RICPR

UniProt

Q9ZDB1 - SYL_RICPR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Leucine--tRNA ligase

Gene
leuS, RP421
Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei598 – 5981ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:RP421
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 828828Leucine--tRNA ligaseUniRule annotationPRO_0000152075Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272947.RP421.

Structurei

3D structure databases

ProteinModelPortaliQ9ZDB1.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi36 – 4611"HIGH" regionUniRule annotationAdd
BLAST
Motifi595 – 5995"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZDB1-1 [UniParc]FASTAAdd to Basket

« Hide

MHKIEKKWQK IWQEEKAFQV SNESSKPKYY VLEMLPYPSG KIHIGHVRNY    50
SIGDVIARFM TMQGFNVLHP MGWDAFGLPA ENAAIKNNSR PQDWTYSNIE 100
YMKKQLQSMG FAYDWTREIN SCDPEYYKHE QKFFLELYDR NLVYQKESLV 150
NWDPVDNTVL ANEQVVDGRG WRSGAIIEKR YLKQWFLKIT DYAEELLNEI 200
QNLKDWPAAV RVMQEEWIGK STGVNFHFKV KYHENTTIEV FSTKPETIFG 250
ASFIGIAFNH PIIEQLICKT PEIVNFITKC SYITRSSEID KAEKEGIFSG 300
LYVIHPFDAN IFLPVIITNF VLMDYGTGAI FGCPAHDKRD HELAIKMNLP 350
IKQVIETGNI QEGILINSDW LNGLTSSEAK QKVIEKFEKL GIGKRSVNYR 400
LKDWSISRQR FWGCPIPMIH CKTCGVVPVP YKDLPVTLPD DVSFDSNYNP 450
LEHHSSWKYV NCPKCDNSAI RETDTFDTFF ESSWYFTRYC NSNAVEMTDK 500
KACNYWLPVD KYIGGIEHAV MHLLYARFFT KLMNEHNYVS IREPFKGLFT 550
QGMVLHATYK DENNNWLYPA EVVKKGNEFF HKENNTRVVQ GRIEKMSKSK 600
KNIIDLETIR EQYSADAIRL FVLSDSPPEK DLEWSASGIE GCSRFINKLE 650
NMFEAIFSLK DDMKSEINKD LNRLIHLTIK HVADDIKTFS LNRAIARMRT 700
LTNAIYYEIS KDRIDVRTIK YGFNVLVQLL NPFIPHITEE IWQKLGNKER 750
LYKSVFAEFD ESILELSTYI MAVQVNGKLR DTYEFDVDIS EDEVKQITVN 800
LPKVQKFLAG KEPRNIILVP RKIVNIIV 828
Length:828
Mass (Da):96,472
Last modified:May 1, 1999 - v1
Checksum:i43BACB6398191986
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235271 Genomic DNA. Translation: CAA14878.1.
PIRiD71700.
RefSeqiNP_220802.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA14878; CAA14878; CAA14878.
GeneIDi883338.
KEGGirpr:RP421.
PATRICi17901623. VBIRicPro72556_0434.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235271 Genomic DNA. Translation: CAA14878.1 .
PIRi D71700.
RefSeqi NP_220802.1. NC_000963.1.

3D structure databases

ProteinModelPortali Q9ZDB1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272947.RP421.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAA14878 ; CAA14878 ; CAA14878 .
GeneIDi 883338.
KEGGi rpr:RP421.
PATRICi 17901623. VBIRicPro72556_0434.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiSYL_RICPR
AccessioniPrimary (citable) accession number: Q9ZDB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi