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Q9ZDB1

- SYL_RICPR

UniProt

Q9ZDB1 - SYL_RICPR

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei598 – 5981ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:RP421
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 828828Leucine--tRNA ligasePRO_0000152075Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272947.RP421.

Structurei

3D structure databases

ProteinModelPortaliQ9ZDB1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi36 – 4611"HIGH" regionAdd
BLAST
Motifi595 – 5995"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZDB1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHKIEKKWQK IWQEEKAFQV SNESSKPKYY VLEMLPYPSG KIHIGHVRNY
60 70 80 90 100
SIGDVIARFM TMQGFNVLHP MGWDAFGLPA ENAAIKNNSR PQDWTYSNIE
110 120 130 140 150
YMKKQLQSMG FAYDWTREIN SCDPEYYKHE QKFFLELYDR NLVYQKESLV
160 170 180 190 200
NWDPVDNTVL ANEQVVDGRG WRSGAIIEKR YLKQWFLKIT DYAEELLNEI
210 220 230 240 250
QNLKDWPAAV RVMQEEWIGK STGVNFHFKV KYHENTTIEV FSTKPETIFG
260 270 280 290 300
ASFIGIAFNH PIIEQLICKT PEIVNFITKC SYITRSSEID KAEKEGIFSG
310 320 330 340 350
LYVIHPFDAN IFLPVIITNF VLMDYGTGAI FGCPAHDKRD HELAIKMNLP
360 370 380 390 400
IKQVIETGNI QEGILINSDW LNGLTSSEAK QKVIEKFEKL GIGKRSVNYR
410 420 430 440 450
LKDWSISRQR FWGCPIPMIH CKTCGVVPVP YKDLPVTLPD DVSFDSNYNP
460 470 480 490 500
LEHHSSWKYV NCPKCDNSAI RETDTFDTFF ESSWYFTRYC NSNAVEMTDK
510 520 530 540 550
KACNYWLPVD KYIGGIEHAV MHLLYARFFT KLMNEHNYVS IREPFKGLFT
560 570 580 590 600
QGMVLHATYK DENNNWLYPA EVVKKGNEFF HKENNTRVVQ GRIEKMSKSK
610 620 630 640 650
KNIIDLETIR EQYSADAIRL FVLSDSPPEK DLEWSASGIE GCSRFINKLE
660 670 680 690 700
NMFEAIFSLK DDMKSEINKD LNRLIHLTIK HVADDIKTFS LNRAIARMRT
710 720 730 740 750
LTNAIYYEIS KDRIDVRTIK YGFNVLVQLL NPFIPHITEE IWQKLGNKER
760 770 780 790 800
LYKSVFAEFD ESILELSTYI MAVQVNGKLR DTYEFDVDIS EDEVKQITVN
810 820
LPKVQKFLAG KEPRNIILVP RKIVNIIV
Length:828
Mass (Da):96,472
Last modified:May 1, 1999 - v1
Checksum:i43BACB6398191986
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235271 Genomic DNA. Translation: CAA14878.1.
PIRiD71700.
RefSeqiNP_220802.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA14878; CAA14878; CAA14878.
GeneIDi883338.
KEGGirpr:RP421.
PATRICi17901623. VBIRicPro72556_0434.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235271 Genomic DNA. Translation: CAA14878.1 .
PIRi D71700.
RefSeqi NP_220802.1. NC_000963.1.

3D structure databases

ProteinModelPortali Q9ZDB1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272947.RP421.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAA14878 ; CAA14878 ; CAA14878 .
GeneIDi 883338.
KEGGi rpr:RP421.
PATRICi 17901623. VBIRicPro72556_0434.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiSYL_RICPR
AccessioniPrimary (citable) accession number: Q9ZDB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3