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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei598ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRPRO272947:G1GT0-423-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:RP421
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000002480 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001520751 – 828Leucine--tRNA ligaseAdd BLAST828

Proteomic databases

PRIDEiQ9ZDB1

Interactioni

Protein-protein interaction databases

STRINGi272947.RP421

Structurei

3D structure databases

ProteinModelPortaliQ9ZDB1
SMRiQ9ZDB1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi36 – 46"HIGH" regionAdd BLAST11
Motifi595 – 599"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 3 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ZDB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHKIEKKWQK IWQEEKAFQV SNESSKPKYY VLEMLPYPSG KIHIGHVRNY
60 70 80 90 100
SIGDVIARFM TMQGFNVLHP MGWDAFGLPA ENAAIKNNSR PQDWTYSNIE
110 120 130 140 150
YMKKQLQSMG FAYDWTREIN SCDPEYYKHE QKFFLELYDR NLVYQKESLV
160 170 180 190 200
NWDPVDNTVL ANEQVVDGRG WRSGAIIEKR YLKQWFLKIT DYAEELLNEI
210 220 230 240 250
QNLKDWPAAV RVMQEEWIGK STGVNFHFKV KYHENTTIEV FSTKPETIFG
260 270 280 290 300
ASFIGIAFNH PIIEQLICKT PEIVNFITKC SYITRSSEID KAEKEGIFSG
310 320 330 340 350
LYVIHPFDAN IFLPVIITNF VLMDYGTGAI FGCPAHDKRD HELAIKMNLP
360 370 380 390 400
IKQVIETGNI QEGILINSDW LNGLTSSEAK QKVIEKFEKL GIGKRSVNYR
410 420 430 440 450
LKDWSISRQR FWGCPIPMIH CKTCGVVPVP YKDLPVTLPD DVSFDSNYNP
460 470 480 490 500
LEHHSSWKYV NCPKCDNSAI RETDTFDTFF ESSWYFTRYC NSNAVEMTDK
510 520 530 540 550
KACNYWLPVD KYIGGIEHAV MHLLYARFFT KLMNEHNYVS IREPFKGLFT
560 570 580 590 600
QGMVLHATYK DENNNWLYPA EVVKKGNEFF HKENNTRVVQ GRIEKMSKSK
610 620 630 640 650
KNIIDLETIR EQYSADAIRL FVLSDSPPEK DLEWSASGIE GCSRFINKLE
660 670 680 690 700
NMFEAIFSLK DDMKSEINKD LNRLIHLTIK HVADDIKTFS LNRAIARMRT
710 720 730 740 750
LTNAIYYEIS KDRIDVRTIK YGFNVLVQLL NPFIPHITEE IWQKLGNKER
760 770 780 790 800
LYKSVFAEFD ESILELSTYI MAVQVNGKLR DTYEFDVDIS EDEVKQITVN
810 820
LPKVQKFLAG KEPRNIILVP RKIVNIIV
Length:828
Mass (Da):96,472
Last modified:May 1, 1999 - v1
Checksum:i43BACB6398191986
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235271 Genomic DNA Translation: CAA14878.1
PIRiD71700
RefSeqiNP_220802.1, NC_000963.1
WP_004599464.1, NC_000963.1

Genome annotation databases

EnsemblBacteriaiCAA14878; CAA14878; CAA14878
GeneIDi883338
KEGGirpr:RP421
PATRICifig|272947.5.peg.434

Similar proteinsi

Entry informationi

Entry nameiSYL_RICPR
AccessioniPrimary (citable) accession number: Q9ZDB1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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