Q9ZDA8 (CDSA_RICPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidate cytidylyltransferase
EC=2.7.7.41

Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name=CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase

Gene names

Name:	cdsA
Ordered Locus Names:	RP424

Organism

Rickettsia prowazekii (strain Madrid E)

Taxonomic identifier

272947 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	228 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the CDS family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphatidate cytidylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 228	228	Phosphatidate cytidylyltransferase		PRO_0000090745
Regions
	Transmembrane	31 – 51	21	Helical; Potential
	Transmembrane	65 – 85	21	Helical; Potential
	Transmembrane	93 – 113	21	Helical; Potential
	Transmembrane	131 – 151	21	Helical; Potential
	Transmembrane	165 – 185	21	Helical; Potential
	Transmembrane	206 – 226	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9ZDA8 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 48DE66AB6EA19174	FASTA	228	25,814
	10 20 30 40 50 60 MITQKEKEHL AKDKQNIYLR IISGIALVSL FVIAILCLKT LFYILMILVG LGMLSEWYNM 70 80 90 100 110 120 TYPSINYLLI GLIIIPIPIS LLIFLSMEES NRLVIMLYFC ILWSVDTFAM IGGKTFKGIK 130 140 150 160 170 180 LAPKISPKKT WTGLITGTVS AGLVSVLVSL IPNYHIEHYY FSNKIYLFII SCILALIAQS 190 200 210 220 SDLFISYFKR KFNIKDSGHI IPGHGGVLDR FDSIILTAPV FFCINIYL

References

[1]

"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed: 9823893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ235271 Genomic DNA. Translation: CAA14881.1.
PIR	G71700.
RefSeq	NP_220805.1. NC_000963.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	883318.
GenomeReviews	Gene locus RP424 in contig AJ235269_GR.
KEGG	rpr:RP424.
PATRIC	17901629. VBIRicPro72556_0437.
Phylogenomic databases
HOGENOM	HBG732679.
OMA	MEDTNRW.
ProtClustDB	CLSK870917.
Enzyme and pathway databases
BioCyc	RPRO272947:RP424-MONOMER.
Family and domain databases
InterPro	IPR000374. PC_trans. [Graphical view]
Pfam	PF01148. CTP_transf_1. 1 hit. [Graphical view]
PROSITE	PS01315. CDS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDSA_RICPR

Accession

Primary (citable) accession number: Q9ZDA8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program