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Q9ZDA8

- CDSA_RICPR

UniProt

Q9ZDA8 - CDSA_RICPR

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Protein

Phosphatidate cytidylyltransferase

Gene
cdsA, RP424
Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathwayi

GO - Molecular functioni

  1. phosphatidate cytidylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00557; UER00614.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate cytidylyltransferase (EC:2.7.7.41)
Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name:
CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase
Gene namesi
Name:cdsA
Ordered Locus Names:RP424
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei31 – 5121Helical; Reviewed predictionAdd
BLAST
Transmembranei65 – 8521Helical; Reviewed predictionAdd
BLAST
Transmembranei93 – 11321Helical; Reviewed predictionAdd
BLAST
Transmembranei131 – 15121Helical; Reviewed predictionAdd
BLAST
Transmembranei165 – 18521Helical; Reviewed predictionAdd
BLAST
Transmembranei206 – 22621Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 228228Phosphatidate cytidylyltransferasePRO_0000090745Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272947.RP424.

Family & Domainsi

Sequence similaritiesi

Belongs to the CDS family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0575.
HOGENOMiHOG000006169.
KOiK00981.
OMAiFLMNIYL.
OrthoDBiEOG6TBHJT.

Family and domain databases

InterProiIPR000374. PC_trans.
[Graphical view]
PfamiPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZDA8-1 [UniParc]FASTAAdd to Basket

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MITQKEKEHL AKDKQNIYLR IISGIALVSL FVIAILCLKT LFYILMILVG    50
LGMLSEWYNM TYPSINYLLI GLIIIPIPIS LLIFLSMEES NRLVIMLYFC 100
ILWSVDTFAM IGGKTFKGIK LAPKISPKKT WTGLITGTVS AGLVSVLVSL 150
IPNYHIEHYY FSNKIYLFII SCILALIAQS SDLFISYFKR KFNIKDSGHI 200
IPGHGGVLDR FDSIILTAPV FFCINIYL 228
Length:228
Mass (Da):25,814
Last modified:May 1, 1999 - v1
Checksum:i48DE66AB6EA19174
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235271 Genomic DNA. Translation: CAA14881.1.
PIRiG71700.
RefSeqiNP_220805.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA14881; CAA14881; CAA14881.
GeneIDi883318.
KEGGirpr:RP424.
PATRICi17901629. VBIRicPro72556_0437.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235271 Genomic DNA. Translation: CAA14881.1 .
PIRi G71700.
RefSeqi NP_220805.1. NC_000963.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272947.RP424.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAA14881 ; CAA14881 ; CAA14881 .
GeneIDi 883318.
KEGGi rpr:RP424.
PATRICi 17901629. VBIRicPro72556_0437.

Phylogenomic databases

eggNOGi COG0575.
HOGENOMi HOG000006169.
KOi K00981.
OMAi FLMNIYL.
OrthoDBi EOG6TBHJT.

Enzyme and pathway databases

UniPathwayi UPA00557 ; UER00614 .

Family and domain databases

InterProi IPR000374. PC_trans.
[Graphical view ]
Pfami PF01148. CTP_transf_1. 1 hit.
[Graphical view ]
PROSITEi PS01315. CDS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiCDSA_RICPR
AccessioniPrimary (citable) accession number: Q9ZDA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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