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Q9ZDA2

- NADK_RICPR

UniProt

Q9ZDA2 - NADK_RICPR

Protein

NAD kinase

Gene

nadK

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei44 – 441Proton acceptorUniRule annotation
    Binding sitei49 – 491NADUniRule annotation
    Binding sitei144 – 1441NADUniRule annotation
    Binding sitei152 – 1521NAD; via carbonyl oxygenUniRule annotation
    Binding sitei216 – 2161NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi44 – 452NADUniRule annotation
    Nucleotide bindingi114 – 1152NADUniRule annotation
    Nucleotide bindingi155 – 1606NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:RP440
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 255255NAD kinasePRO_0000120653Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272947.RP440.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZDA2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000139847.
    KOiK00858.
    OMAiHESTVSI.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9ZDA2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNINKIALIY NKNSKHLAII EEIKKLYNYC KIEEAEVIII IGGDGELLHN    50
    IHRYMHLNIP FYGLNLGSLG FLMNPLDTKK LLQNIYESTV SILHPLLMQV 100
    EDTSGQIYKA LAINEVSIFR KTNQVAKFRI DVNGVERMSE LVADGALVAT 150
    PAGSSAYNLS AGGPILPLAS NMLCLTPICS FRPRRWHGAL LLSTDTIKFE 200
    ILNITKRPVN ATADFQEFNN ITRVTVKSTK DKYIKLLFNK NHTLEDRIIK 250
    EQFGE 255
    Length:255
    Mass (Da):28,776
    Last modified:May 1, 1999 - v1
    Checksum:iC56DF4BD2462D529
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235271 Genomic DNA. Translation: CAA14897.1.
    PIRiG71702.
    RefSeqiNP_220821.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA14897; CAA14897; CAA14897.
    GeneIDi883321.
    KEGGirpr:RP440.
    PATRICi17901661. VBIRicPro72556_0453.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235271 Genomic DNA. Translation: CAA14897.1 .
    PIRi G71702.
    RefSeqi NP_220821.1. NC_000963.1.

    3D structure databases

    ProteinModelPortali Q9ZDA2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP440.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA14897 ; CAA14897 ; CAA14897 .
    GeneIDi 883321.
    KEGGi rpr:RP440.
    PATRICi 17901661. VBIRicPro72556_0453.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000139847.
    KOi K00858.
    OMAi HESTVSI.
    OrthoDBi EOG6PZXDR.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.

    Entry informationi

    Entry nameiNADK_RICPR
    AccessioniPrimary (citable) accession number: Q9ZDA2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3