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Q9ZDA0

- GPDA_RICPR

UniProt

Q9ZDA0 - GPDA_RICPR

Protein

Glycerol-3-phosphate dehydrogenase [NAD(P)+]

Gene

gpsA

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei109 – 1091NAD; via amide nitrogenUniRule annotation
    Binding sitei109 – 1091SubstrateUniRule annotation
    Binding sitei141 – 1411NAD; via amide nitrogenUniRule annotation
    Active sitei192 – 1921Proton acceptorUniRule annotation
    Binding sitei259 – 2591NADUniRule annotation
    Binding sitei285 – 2851NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 166NADUniRule annotation

    GO - Molecular functioni

    1. glycerol-3-phosphate dehydrogenase [NAD(P)+] activity Source: UniProtKB-HAMAP
    2. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
    3. glycerol-3-phosphate dehydrogenase [NADP+] activity Source: UniProtKB-EC
    4. NAD binding Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. glycerol-3-phosphate biosynthetic process Source: UniProtKB-HAMAP
    3. glycerol-3-phosphate catabolic process Source: InterPro
    4. glycerophospholipid metabolic process Source: UniProtKB-UniPathway
    5. phospholipid biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00940.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycerol-3-phosphate dehydrogenase [NAD(P)+]UniRule annotation (EC:1.1.1.94UniRule annotation)
    Alternative name(s):
    NAD(P)H-dependent glycerol-3-phosphate dehydrogenaseUniRule annotation
    Gene namesi
    Name:gpsAUniRule annotation
    Ordered Locus Names:RP442
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. glycerol-3-phosphate dehydrogenase complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 316316Glycerol-3-phosphate dehydrogenase [NAD(P)+]PRO_0000138017Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272947.RP442.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZDA0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni259 – 2602Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0240.
    HOGENOMiHOG000246854.
    KOiK00057.
    OMAiLMEIAVF.
    OrthoDBiEOG6JDWF4.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    HAMAPiMF_00394. NAD_Glyc3P_dehydrog.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR006168. G3P_DH_NAD-dep.
    IPR006109. G3P_DH_NAD-dep_C.
    IPR011128. G3P_DH_NAD-dep_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11728. PTHR11728. 1 hit.
    PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
    PF01210. NAD_Gly3P_dh_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
    PRINTSiPR00077. GPDHDRGNASE.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    PROSITEiPS00957. NAD_G3PDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZDA0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKFKNIAVY GGGSFGTSLA SLVARNCNNV TLFLRDEIIL KEILYKKTNA    50
    QYLGDIELPT NLQATTNLSV IKDFELIIIA VPSYAFDDSI KLLKTYGISK 100
    EHTILVATKG LADNPTELFS DRLNTLLPDN PIGFLSGPNL AKELAKNLPA 150
    SASIASLDID IANKIAYNFS SKTFSTNTTI DIVTLQIAGA LKNIFAIKSG 200
    IDLAREQGAN SRATLIVGAL KEITTLSKVL GGMQKNSDIL LEAGVLGDLV 250
    LTCYSLGSRN TKFGYEFEIS RDKKKFLCEY KELVEGREAL KLVLDLIKKY 300
    NLHMPIVAEV ASLILI 316
    Length:316
    Mass (Da):34,487
    Last modified:May 1, 1999 - v1
    Checksum:iEBA9E84E19874D42
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235271 Genomic DNA. Translation: CAA14899.1.
    PIRiA71703.
    RefSeqiNP_220823.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA14899; CAA14899; CAA14899.
    GeneIDi883324.
    KEGGirpr:RP442.
    PATRICi17901665. VBIRicPro72556_0455.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235271 Genomic DNA. Translation: CAA14899.1 .
    PIRi A71703.
    RefSeqi NP_220823.1. NC_000963.1.

    3D structure databases

    ProteinModelPortali Q9ZDA0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP442.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA14899 ; CAA14899 ; CAA14899 .
    GeneIDi 883324.
    KEGGi rpr:RP442.
    PATRICi 17901665. VBIRicPro72556_0455.

    Phylogenomic databases

    eggNOGi COG0240.
    HOGENOMi HOG000246854.
    KOi K00057.
    OMAi LMEIAVF.
    OrthoDBi EOG6JDWF4.

    Enzyme and pathway databases

    UniPathwayi UPA00940 .

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    HAMAPi MF_00394. NAD_Glyc3P_dehydrog.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR006168. G3P_DH_NAD-dep.
    IPR006109. G3P_DH_NAD-dep_C.
    IPR011128. G3P_DH_NAD-dep_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11728. PTHR11728. 1 hit.
    Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
    PF01210. NAD_Gly3P_dh_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000114. Glycerol-3-P_dh. 1 hit.
    PRINTSi PR00077. GPDHDRGNASE.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    PROSITEi PS00957. NAD_G3PDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.

    Entry informationi

    Entry nameiGPDA_RICPR
    AccessioniPrimary (citable) accession number: Q9ZDA0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3