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Q9ZDA0 (GPDA_RICPR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycerol-3-phosphate dehydrogenase [NAD(P)+]
EC=1.1.1.94
Alternative name(s):
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase
Gene names
Name:gpsA
Ordered Locus Names:RP442
OrganismRickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]
Taxonomic identifier272947 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group ›

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H. HAMAP-Rule MF_00394

Pathway

Membrane lipid metabolism; glycerophospholipid metabolism. HAMAP-Rule MF_00394

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 316316Glycerol-3-phosphate dehydrogenase [NAD(P)+] HAMAP-Rule MF_00394
PRO_0000138017

Regions

Nucleotide binding11 – 166NAD By similarity
Region259 – 2602Substrate binding By similarity

Sites

Active site1921Proton acceptor By similarity
Binding site1091NAD; via amide nitrogen By similarity
Binding site1091Substrate By similarity
Binding site1411NAD; via amide nitrogen By similarity
Binding site2591NAD By similarity
Binding site2851NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ZDA0 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: EBA9E84E19874D42

FASTA31634,487
        10         20         30         40         50         60 
MNKFKNIAVY GGGSFGTSLA SLVARNCNNV TLFLRDEIIL KEILYKKTNA QYLGDIELPT 

        70         80         90        100        110        120 
NLQATTNLSV IKDFELIIIA VPSYAFDDSI KLLKTYGISK EHTILVATKG LADNPTELFS 

       130        140        150        160        170        180 
DRLNTLLPDN PIGFLSGPNL AKELAKNLPA SASIASLDID IANKIAYNFS SKTFSTNTTI 

       190        200        210        220        230        240 
DIVTLQIAGA LKNIFAIKSG IDLAREQGAN SRATLIVGAL KEITTLSKVL GGMQKNSDIL 

       250        260        270        280        290        300 
LEAGVLGDLV LTCYSLGSRN TKFGYEFEIS RDKKKFLCEY KELVEGREAL KLVLDLIKKY 

       310 
NLHMPIVAEV ASLILI

« Hide

References

[1]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ235271 Genomic DNA. Translation: CAA14899.1.
PIRA71703.
RefSeqNP_220823.1. NC_000963.1.

3D structure databases

ProteinModelPortalQ9ZDA0.
ModBaseSearch...

Protein-protein interaction databases

STRING272947.RP442.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAA14899; CAA14899; CAA14899.
GeneID883324.
KEGGrpr:RP442.
PATRIC17901665. VBIRicPro72556_0455.

Phylogenomic databases

eggNOGCOG0240.
HOGENOMHOG000246854.
KOK00057.
OMAVARNCNN.
ProtClustDBPRK00094.

Enzyme and pathway databases

UniPathwayUPA00940.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPMF_00394. NAD_Glyc3P_dehydrog.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11728. PTHR11728. 1 hit.
PfamPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSPR00077. GPDHDRGNASE.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
PROSITEPS00957. NAD_G3PDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPDA_RICPR
AccessionPrimary (citable) accession number: Q9ZDA0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 1999
Last modified: May 1, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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