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Protein

Glycerol-3-phosphate dehydrogenase [NAD(P)+]

Gene

gpsA

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H.UniRule annotation

Pathwayi: glycerophospholipid metabolism

This protein is involved in the pathway glycerophospholipid metabolism, which is part of Membrane lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycerophospholipid metabolism and in Membrane lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei109NAD; via amide nitrogenUniRule annotation1
Binding sitei109SubstrateUniRule annotation1
Binding sitei141NAD; via amide nitrogenUniRule annotation1
Active sitei192Proton acceptorUniRule annotation1
Binding sitei259NADUniRule annotation1
Binding sitei285NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 16NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandNAD

Enzyme and pathway databases

BioCyciRPRO272947:G1GT0-444-MONOMER
BRENDAi1.1.1.94 5447
UniPathwayiUPA00940

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(P)+]UniRule annotation (EC:1.1.1.94UniRule annotation)
Alternative name(s):
NAD(P)H-dependent glycerol-3-phosphate dehydrogenaseUniRule annotation
Gene namesi
Name:gpsAUniRule annotation
Ordered Locus Names:RP442
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000002480 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001380171 – 316Glycerol-3-phosphate dehydrogenase [NAD(P)+]Add BLAST316

Interactioni

Protein-protein interaction databases

STRINGi272947.RP442

Structurei

3D structure databases

ProteinModelPortaliQ9ZDA0
SMRiQ9ZDA0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni259 – 260Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CSF Bacteria
COG0240 LUCA
HOGENOMiHOG000246854
KOiK00057
OMAiWLCKGFE

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
HAMAPiMF_00394 NAD_Glyc3P_dehydrog, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006168 G3P_DH_NAD-dep
IPR006109 G3P_DH_NAD-dep_C
IPR011128 G3P_DH_NAD-dep_N
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF07479 NAD_Gly3P_dh_C, 1 hit
PF01210 NAD_Gly3P_dh_N, 1 hit
PIRSFiPIRSF000114 Glycerol-3-P_dh, 1 hit
PRINTSiPR00077 GPDHDRGNASE
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00957 NAD_G3PDH, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ZDA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKFKNIAVY GGGSFGTSLA SLVARNCNNV TLFLRDEIIL KEILYKKTNA
60 70 80 90 100
QYLGDIELPT NLQATTNLSV IKDFELIIIA VPSYAFDDSI KLLKTYGISK
110 120 130 140 150
EHTILVATKG LADNPTELFS DRLNTLLPDN PIGFLSGPNL AKELAKNLPA
160 170 180 190 200
SASIASLDID IANKIAYNFS SKTFSTNTTI DIVTLQIAGA LKNIFAIKSG
210 220 230 240 250
IDLAREQGAN SRATLIVGAL KEITTLSKVL GGMQKNSDIL LEAGVLGDLV
260 270 280 290 300
LTCYSLGSRN TKFGYEFEIS RDKKKFLCEY KELVEGREAL KLVLDLIKKY
310
NLHMPIVAEV ASLILI
Length:316
Mass (Da):34,487
Last modified:May 1, 1999 - v1
Checksum:iEBA9E84E19874D42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235271 Genomic DNA Translation: CAA14899.1
PIRiA71703
RefSeqiNP_220823.1, NC_000963.1
WP_004599474.1, NC_000963.1

Genome annotation databases

EnsemblBacteriaiCAA14899; CAA14899; CAA14899
GeneIDi883324
KEGGirpr:RP442
PATRICifig|272947.5.peg.455

Similar proteinsi

Entry informationi

Entry nameiGPDA_RICPR
AccessioniPrimary (citable) accession number: Q9ZDA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 1999
Last modified: April 25, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health