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Q9ZDA0

- GPDA_RICPR

UniProt

Q9ZDA0 - GPDA_RICPR

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Protein
Glycerol-3-phosphate dehydrogenase [NAD(P)+]
Gene
gpsA, RP442
Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei109 – 1091NAD; via amide nitrogen By similarity
Binding sitei109 – 1091Substrate By similarity
Binding sitei141 – 1411NAD; via amide nitrogen By similarity
Active sitei192 – 1921Proton acceptor By similarity
Binding sitei259 – 2591NAD By similarity
Binding sitei285 – 2851NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 166NAD By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. glycerol-3-phosphate dehydrogenase [NAD(P)+] activity Source: UniProtKB-HAMAP
  3. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
  4. glycerol-3-phosphate dehydrogenase [NADP+] activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. glycerol-3-phosphate biosynthetic process Source: UniProtKB-HAMAP
  3. glycerol-3-phosphate catabolic process Source: InterPro
  4. glycerophospholipid metabolic process Source: UniProtKB-UniPathway
  5. phospholipid biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00940.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC:1.1.1.94)
Alternative name(s):
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase
Gene namesi
Name:gpsA
Ordered Locus Names:RP442
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Glycerol-3-phosphate dehydrogenase [NAD(P)+]UniRule annotation
PRO_0000138017Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272947.RP442.

Structurei

3D structure databases

ProteinModelPortaliQ9ZDA0.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni259 – 2602Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0240.
HOGENOMiHOG000246854.
KOiK00057.
OMAiLMEIAVF.
OrthoDBiEOG6JDWF4.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPiMF_00394. NAD_Glyc3P_dehydrog.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZDA0-1 [UniParc]FASTAAdd to Basket

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MNKFKNIAVY GGGSFGTSLA SLVARNCNNV TLFLRDEIIL KEILYKKTNA    50
QYLGDIELPT NLQATTNLSV IKDFELIIIA VPSYAFDDSI KLLKTYGISK 100
EHTILVATKG LADNPTELFS DRLNTLLPDN PIGFLSGPNL AKELAKNLPA 150
SASIASLDID IANKIAYNFS SKTFSTNTTI DIVTLQIAGA LKNIFAIKSG 200
IDLAREQGAN SRATLIVGAL KEITTLSKVL GGMQKNSDIL LEAGVLGDLV 250
LTCYSLGSRN TKFGYEFEIS RDKKKFLCEY KELVEGREAL KLVLDLIKKY 300
NLHMPIVAEV ASLILI 316
Length:316
Mass (Da):34,487
Last modified:May 1, 1999 - v1
Checksum:iEBA9E84E19874D42
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235271 Genomic DNA. Translation: CAA14899.1.
PIRiA71703.
RefSeqiNP_220823.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA14899; CAA14899; CAA14899.
GeneIDi883324.
KEGGirpr:RP442.
PATRICi17901665. VBIRicPro72556_0455.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235271 Genomic DNA. Translation: CAA14899.1 .
PIRi A71703.
RefSeqi NP_220823.1. NC_000963.1.

3D structure databases

ProteinModelPortali Q9ZDA0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272947.RP442.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAA14899 ; CAA14899 ; CAA14899 .
GeneIDi 883324.
KEGGi rpr:RP442.
PATRICi 17901665. VBIRicPro72556_0455.

Phylogenomic databases

eggNOGi COG0240.
HOGENOMi HOG000246854.
KOi K00057.
OMAi LMEIAVF.
OrthoDBi EOG6JDWF4.

Enzyme and pathway databases

UniPathwayi UPA00940 .

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPi MF_00394. NAD_Glyc3P_dehydrog.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11728. PTHR11728. 1 hit.
Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSi PR00077. GPDHDRGNASE.
SUPFAMi SSF48179. SSF48179. 1 hit.
PROSITEi PS00957. NAD_G3PDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiGPDA_RICPR
AccessioniPrimary (citable) accession number: Q9ZDA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi