Q9ZD97 (TRXB_RICPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thioredoxin reductase
Short name=TRXR
EC=1.8.1.9

Gene names

Name:	trxB
Ordered Locus Names:	RP445

Organism

Rickettsia prowazekii (strain Madrid E)

Taxonomic identifier

272947 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.
Cofactor	Binds 1 FAD per subunit By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Miscellaneous	The active site is a redox-active disulfide bond.
Sequence similarities	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Redox-active center
Ligand	FAD Flavoprotein NADP
Molecular function	Oxidoreductase
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	removal of superoxide radicals Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro thioredoxin-disulfide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	Thioredoxin reductase		PRO_0000166743
Regions
	Nucleotide binding	34 – 41	8	FAD By similarity
	Nucleotide binding	281 – 290	10	FAD By similarity
Amino acid modifications
	Disulfide bond	135 ↔ 138		Redox-active By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ZD97 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 573CA975C750957D	FASTA	310	33,582
	10 20 30 40 50 60 MKITTKVLII GSGPAGLSAA IYTARSALKP ILINGMQPGG QLTMTTDVEN YPGFAETIQG 70 80 90 100 110 120 PWLMEQMSMQ AKNVGTEIIS DYVERVDLSK RPFKIFTGTG NEYEADSIII CTGAESKWLG 130 140 150 160 170 180 IASEQEFRGF GVSSCAICDG FFFKNQEIVV VGGGNSALEE ALYLTNHANK VTVVHRRNSF 190 200 210 220 230 240 RAEKILQDRL FKNPKISVIW DHIIDEIVGS NKPKAVTGVK IQNVYTNEIN LVNCSGVFIA 250 260 270 280 290 300 IGHAPNTALF KGQIAIDDDN YIVTQSGSTR TNVEGVFAAG DVQDKIYRQA VTAAASGCMA 310 ALEVAKFLNK

References

[1]	"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed: 9823893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ235271 Genomic DNA. Translation: CAA14902.1.
PIR	D71703.
RefSeq	NP_220826.1. NC_000963.1.
3D structure databases
ProteinModelPortal	Q9ZD97.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	883344.
GenomeReviews	Gene locus RP445 in contig AJ235269_GR.
KEGG	rpr:RP445.
PATRIC	17901671. VBIRicPro72556_0458.
Phylogenomic databases
HOGENOM	HBG669726.
OMA	VMGAFIA.
ProtClustDB	CLSK870928.
Enzyme and pathway databases
BioCyc	RPRO272947:RP445-MONOMER.
Family and domain databases
InterPro	IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR008255. Pyr_nucl-diS_OxRdtase_2_AS. IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD. IPR001327. Pyr_OxRdtase_NAD-bd_dom. IPR000103. Pyridine_nuc-diS_OxRdtase_2. IPR005982. Thioredox_Rdtase. [Graphical view]
KO	K00384.
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR. PR00469. PNDRDTASEII.
TIGRFAMs	TIGR01292. TRX_reduct. 1 hit.
PROSITE	PS00573. PYRIDINE_REDOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRXB_RICPR

Accession

Primary (citable) accession number: Q9ZD97

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program