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Q9ZD90 (IDI2_RICPR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Isopentenyl-diphosphate delta-isomerase

Short name=IPP isomerase
EC=5.3.3.2
Alternative name(s):
Isopentenyl pyrophosphate isomerase
Gene names
Name:fni
Ordered Locus Names:RP452
OrganismRickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]
Taxonomic identifier272947 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) By similarity. HAMAP-Rule MF_00354

Catalytic activity

Isopentenyl diphosphate = dimethylallyl diphosphate. HAMAP-Rule MF_00354

Cofactor

FMN By similarity. HAMAP-Rule MF_00354

NADPH By similarity. HAMAP-Rule MF_00354

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00354.

Sequence similarities

Belongs to the IPP isomerase type 2 family.

Ontologies

Keywords
   Biological processIsoprene biosynthesis
   Cellular componentCytoplasm
   LigandFlavoprotein
FMN
NADP
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processisoprenoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionFMN binding

Inferred from electronic annotation. Source: InterPro

isopentenyl-diphosphate delta-isomerase activity

Inferred from electronic annotation. Source: UniProtKB-EC

oxidoreductase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 342342Isopentenyl-diphosphate delta-isomerase HAMAP-Rule MF_00354
PRO_0000134419

Sequences

Sequence LengthMass (Da)Tools
Q9ZD90 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: FE452A843CA1B950

FASTA34237,364
        10         20         30         40         50         60 
MPKEQNLDIE RKQEHIEINL KQNVNSTLKS GLESIKFIHN ALPEINYDSI DTTTTFLGKD 

        70         80         90        100        110        120 
MKAPILISSM TGGTARARDI NYRLAQAAQK SGIAMGLGSM RILLTKPDTI KTFTVRHVAP 

       130        140        150        160        170        180 
DIPLLANIGA VQLNYGVTPK ECQYLIDTIK ADALILHLNV LHELTQPEGN KNWENLLPKI 

       190        200        210        220        230        240 
KEVINYLSVP VIVKEVGYGL SKQVAKKLIK AGVKVLDIAG SGGTSWSQVE AYRAKNSMQN 

       250        260        270        280        290        300 
RIASSFINWG ITTLDSLKML QEISKDITII ASGGLQSGID GAKAIRMGAN IFGLAGKLLK 

       310        320        330        340 
AADIAESLVL EEIQVIIEQL KITMLCTGSC TLKDLAKAEI MW 

« Hide

References

[1]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ235271 Genomic DNA. Translation: CAA14909.1.
PIRC71704.
RefSeqNP_220833.1. NC_000963.1.

3D structure databases

ProteinModelPortalQ9ZD90.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272947.RP452.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAA14909; CAA14909; CAA14909.
GeneID883361.
KEGGrpr:RP452.
PATRIC17901685. VBIRicPro72556_0465.

Phylogenomic databases

eggNOGCOG1304.
HOGENOMHOG000072126.
KOK01823.
OMAFEFPFYI.
OrthoDBEOG62C9GJ.
ProtClustDBPRK05437.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00354. Idi_2.
InterProIPR013785. Aldolase_TIM.
IPR000262. FMN-dep_DH.
IPR011179. IPdP_isomerase.
[Graphical view]
PANTHERPTHR10578:SF3. PTHR10578:SF3. 1 hit.
PfamPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFPIRSF003314. IPP_isomerase. 1 hit.
TIGRFAMsTIGR02151. IPP_isom_2. 1 hit.
ProtoNetSearch...

Entry information

Entry nameIDI2_RICPR
AccessionPrimary (citable) accession number: Q9ZD90
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 1999
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names