Q9ZD90 (IDI2_RICPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Isopentenyl-diphosphate delta-isomerase
Short name=IPP isomerase
EC=5.3.3.2

Alternative name(s):
Isopentenyl pyrophosphate isomerase

Gene names

Name:	fni
Ordered Locus Names:	RP452

Organism

Rickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]

Taxonomic identifier

272947 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group › Rickettsia prowazekii

Protein attributes

Sequence length	342 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) By similarity. HAMAP-Rule MF_00354
Catalytic activity	Isopentenyl diphosphate = dimethylallyl diphosphate. HAMAP-Rule MF_00354
Cofactor	FMN By similarity. NADPH By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the IPP isomerase type 2 family.

Ontologies

Keywords
Biological process	Isoprene biosynthesis
Cellular component	Cytoplasm
Ligand	FMN Flavoprotein NADP
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	isoprenoid biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation-reduction process Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	FMN binding Inferred from electronic annotation. Source: InterPro isopentenyl-diphosphate delta-isomerase activity Inferred from electronic annotation. Source: HAMAP oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 342	342	Isopentenyl-diphosphate delta-isomerase HAMAP-Rule MF_00354		PRO_0000134419

Sequences

	Sequence		Length	Mass (Da)
	Q9ZD90 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: FE452A843CA1B950	FASTA	342	37,364
	10 20 30 40 50 60 MPKEQNLDIE RKQEHIEINL KQNVNSTLKS GLESIKFIHN ALPEINYDSI DTTTTFLGKD 70 80 90 100 110 120 MKAPILISSM TGGTARARDI NYRLAQAAQK SGIAMGLGSM RILLTKPDTI KTFTVRHVAP 130 140 150 160 170 180 DIPLLANIGA VQLNYGVTPK ECQYLIDTIK ADALILHLNV LHELTQPEGN KNWENLLPKI 190 200 210 220 230 240 KEVINYLSVP VIVKEVGYGL SKQVAKKLIK AGVKVLDIAG SGGTSWSQVE AYRAKNSMQN 250 260 270 280 290 300 RIASSFINWG ITTLDSLKML QEISKDITII ASGGLQSGID GAKAIRMGAN IFGLAGKLLK 310 320 330 340 AADIAESLVL EEIQVIIEQL KITMLCTGSC TLKDLAKAEI MW

References

[1]

"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ235271 Genomic DNA. Translation: CAA14909.1.
PIR	C71704.
RefSeq	NP_220833.1. NC_000963.1.
3D structure databases
ProteinModelPortal	Q9ZD90.
ModBase	Search...
Protein-protein interaction databases
STRING	272947.RP452.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAA14909; CAA14909; CAA14909.
GeneID	883361.
KEGG	rpr:RP452.
PATRIC	17901685. VBIRicPro72556_0465.
Phylogenomic databases
eggNOG	COG1304.
HOGENOM	HOG000072126.
KO	K01823.
OMA	FEFPFYI.
ProtClustDB	PRK05437.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
HAMAP	MF_00354. Idi_2.
InterPro	IPR013785. Aldolase_TIM. IPR000262. FMN-dep_DH. IPR011179. IPdP_isomerase. [Graphical view]
PANTHER	PTHR10578:SF3. PTHR10578:SF3. 1 hit.
Pfam	PF01070. FMN_dh. 2 hits. [Graphical view]
PIRSF	PIRSF003314. IPP_isomerase. 1 hit.
TIGRFAMs	TIGR02151. IPP_isom_2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

IDI2_RICPR

Accession

Primary (citable) accession number: Q9ZD90

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program