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Protein

Isopentenyl-diphosphate delta-isomerase

Gene

fni

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).UniRule annotation

Catalytic activityi

Isopentenyl diphosphate = dimethylallyl diphosphate.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • FMNUniRule annotation
  • NADPHUniRule annotation
  • Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei68FMNUniRule annotation1
Binding sitei99FMN; via amide nitrogenUniRule annotation1
Binding sitei127FMNUniRule annotation1
Metal bindingi163MagnesiumUniRule annotation1
Binding sitei194FMNUniRule annotation1
Binding sitei224FMN; via amide nitrogenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi69 – 71FMNUniRule annotation3
Nucleotide bindingi295 – 296FMNUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processIsoprene biosynthesis
LigandFlavoprotein, FMN, Magnesium, Metal-binding, NADP

Enzyme and pathway databases

BioCyciRPRO272947:G1GT0-454-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Isopentenyl-diphosphate delta-isomeraseUniRule annotation (EC:5.3.3.2UniRule annotation)
Short name:
IPP isomeraseUniRule annotation
Alternative name(s):
Isopentenyl diphosphate:dimethylallyl diphosphate isomeraseUniRule annotation
Isopentenyl pyrophosphate isomeraseUniRule annotation
Type 2 isopentenyl diphosphate isomeraseUniRule annotation
Short name:
IDI-2UniRule annotation
Gene namesi
Name:fniUniRule annotation
Ordered Locus Names:RP452
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000002480 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001344191 – 342Isopentenyl-diphosphate delta-isomeraseAdd BLAST342

Interactioni

Subunit structurei

Homooctamer. Dimer of tetramers.UniRule annotation

Protein-protein interaction databases

STRINGi272947.RP452

Structurei

3D structure databases

ProteinModelPortaliQ9ZD90
SMRiQ9ZD90
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni11 – 12Substrate bindingUniRule annotation2
Regioni99 – 101Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the IPP isomerase type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4106UJV Bacteria
COG1304 LUCA
HOGENOMiHOG000072126
KOiK01823
OMAiWDWGIPT

Family and domain databases

CDDicd02811 IDI-2_FMN, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00354 Idi_2, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR000262 FMN-dep_DH
IPR011179 IPdP_isomerase
PANTHERiPTHR43665 PTHR43665, 1 hit
PfamiView protein in Pfam
PF01070 FMN_dh, 2 hits
PIRSFiPIRSF003314 IPP_isomerase, 1 hit
TIGRFAMsiTIGR02151 IPP_isom_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ZD90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKEQNLDIE RKQEHIEINL KQNVNSTLKS GLESIKFIHN ALPEINYDSI
60 70 80 90 100
DTTTTFLGKD MKAPILISSM TGGTARARDI NYRLAQAAQK SGIAMGLGSM
110 120 130 140 150
RILLTKPDTI KTFTVRHVAP DIPLLANIGA VQLNYGVTPK ECQYLIDTIK
160 170 180 190 200
ADALILHLNV LHELTQPEGN KNWENLLPKI KEVINYLSVP VIVKEVGYGL
210 220 230 240 250
SKQVAKKLIK AGVKVLDIAG SGGTSWSQVE AYRAKNSMQN RIASSFINWG
260 270 280 290 300
ITTLDSLKML QEISKDITII ASGGLQSGID GAKAIRMGAN IFGLAGKLLK
310 320 330 340
AADIAESLVL EEIQVIIEQL KITMLCTGSC TLKDLAKAEI MW
Length:342
Mass (Da):37,364
Last modified:May 1, 1999 - v1
Checksum:iFE452A843CA1B950
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235271 Genomic DNA Translation: CAA14909.1
PIRiC71704
RefSeqiNP_220833.1, NC_000963.1
WP_004599487.1, NC_000963.1

Genome annotation databases

EnsemblBacteriaiCAA14909; CAA14909; CAA14909
GeneIDi883361
KEGGirpr:RP452
PATRICifig|272947.5.peg.465

Similar proteinsi

Entry informationi

Entry nameiIDI2_RICPR
AccessioniPrimary (citable) accession number: Q9ZD90
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health