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Q9ZD90

- IDI2_RICPR

UniProt

Q9ZD90 - IDI2_RICPR

Protein

Isopentenyl-diphosphate delta-isomerase

Gene

fni

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).UniRule annotation

    Catalytic activityi

    Isopentenyl diphosphate = dimethylallyl diphosphate.UniRule annotation

    Cofactori

    FMN.UniRule annotation
    NADPH.UniRule annotation
    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei68 – 681FMNUniRule annotation
    Binding sitei99 – 991FMN; via amide nitrogenUniRule annotation
    Binding sitei127 – 1271FMNUniRule annotation
    Metal bindingi163 – 1631MagnesiumUniRule annotation
    Binding sitei194 – 1941FMNUniRule annotation
    Binding sitei224 – 2241FMN; via amide nitrogenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi69 – 713FMNUniRule annotation
    Nucleotide bindingi295 – 2962FMNUniRule annotation

    GO - Molecular functioni

    1. FMN binding Source: InterPro
    2. isopentenyl-diphosphate delta-isomerase activity Source: UniProtKB-EC
    3. oxidoreductase activity Source: InterPro

    GO - Biological processi

    1. isoprenoid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Isoprene biosynthesis

    Keywords - Ligandi

    Flavoprotein, FMN, Magnesium, Metal-binding, NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isopentenyl-diphosphate delta-isomeraseUniRule annotation (EC:5.3.3.2UniRule annotation)
    Short name:
    IPP isomeraseUniRule annotation
    Alternative name(s):
    Isopentenyl diphosphate:dimethylallyl diphosphate isomeraseUniRule annotation
    Isopentenyl pyrophosphate isomeraseUniRule annotation
    Type 2 isopentenyl diphosphate isomeraseUniRule annotation
    Short name:
    IDI-2UniRule annotation
    Gene namesi
    Name:fniUniRule annotation
    Ordered Locus Names:RP452
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 342342Isopentenyl-diphosphate delta-isomerasePRO_0000134419Add
    BLAST

    Interactioni

    Subunit structurei

    Homooctamer. Dimer of tetramers.UniRule annotation

    Protein-protein interaction databases

    STRINGi272947.RP452.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZD90.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni11 – 122Substrate bindingUniRule annotation
    Regioni99 – 1013Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the IPP isomerase type 2 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1304.
    HOGENOMiHOG000072126.
    KOiK01823.
    OMAiFEFPFYI.
    OrthoDBiEOG62C9GJ.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00354. Idi_2.
    InterProiIPR013785. Aldolase_TIM.
    IPR000262. FMN-dep_DH.
    IPR011179. IPdP_isomerase.
    [Graphical view]
    PANTHERiPTHR10578:SF3. PTHR10578:SF3. 1 hit.
    PfamiPF01070. FMN_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003314. IPP_isomerase. 1 hit.
    TIGRFAMsiTIGR02151. IPP_isom_2. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9ZD90-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPKEQNLDIE RKQEHIEINL KQNVNSTLKS GLESIKFIHN ALPEINYDSI    50
    DTTTTFLGKD MKAPILISSM TGGTARARDI NYRLAQAAQK SGIAMGLGSM 100
    RILLTKPDTI KTFTVRHVAP DIPLLANIGA VQLNYGVTPK ECQYLIDTIK 150
    ADALILHLNV LHELTQPEGN KNWENLLPKI KEVINYLSVP VIVKEVGYGL 200
    SKQVAKKLIK AGVKVLDIAG SGGTSWSQVE AYRAKNSMQN RIASSFINWG 250
    ITTLDSLKML QEISKDITII ASGGLQSGID GAKAIRMGAN IFGLAGKLLK 300
    AADIAESLVL EEIQVIIEQL KITMLCTGSC TLKDLAKAEI MW 342
    Length:342
    Mass (Da):37,364
    Last modified:May 1, 1999 - v1
    Checksum:iFE452A843CA1B950
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235271 Genomic DNA. Translation: CAA14909.1.
    PIRiC71704.
    RefSeqiNP_220833.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA14909; CAA14909; CAA14909.
    GeneIDi883361.
    KEGGirpr:RP452.
    PATRICi17901685. VBIRicPro72556_0465.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235271 Genomic DNA. Translation: CAA14909.1 .
    PIRi C71704.
    RefSeqi NP_220833.1. NC_000963.1.

    3D structure databases

    ProteinModelPortali Q9ZD90.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP452.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA14909 ; CAA14909 ; CAA14909 .
    GeneIDi 883361.
    KEGGi rpr:RP452.
    PATRICi 17901685. VBIRicPro72556_0465.

    Phylogenomic databases

    eggNOGi COG1304.
    HOGENOMi HOG000072126.
    KOi K01823.
    OMAi FEFPFYI.
    OrthoDBi EOG62C9GJ.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00354. Idi_2.
    InterProi IPR013785. Aldolase_TIM.
    IPR000262. FMN-dep_DH.
    IPR011179. IPdP_isomerase.
    [Graphical view ]
    PANTHERi PTHR10578:SF3. PTHR10578:SF3. 1 hit.
    Pfami PF01070. FMN_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003314. IPP_isomerase. 1 hit.
    TIGRFAMsi TIGR02151. IPP_isom_2. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.

    Entry informationi

    Entry nameiIDI2_RICPR
    AccessioniPrimary (citable) accession number: Q9ZD90
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3