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Q9ZD46 (TRUB_RICPR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative tRNA pseudouridine synthase B

EC=5.4.99.25
Alternative name(s):
tRNA pseudouridine(55) synthase
Short name=Psi55 synthase
tRNA pseudouridylate synthase
tRNA-uridine isomerase
Gene names
Name:truB
Ordered Locus Names:RP501
OrganismRickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]
Taxonomic identifier272947 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length172 AA.
Sequence statusComplete.
Protein existenceUncertain

General annotation (Comments)

Function

Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs By similarity.

Catalytic activity

tRNA uridine55 = tRNA pseudouridine55.

Sequence similarities

Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.

Caution

Could be the product of a pseudogene. C-terminally truncated compared to other bacterial TruB.

Ontologies

Keywords
   Biological processtRNA processing
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpseudouridine synthesis

Inferred from electronic annotation. Source: InterPro

tRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: InterPro

pseudouridine synthase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 172172Putative tRNA pseudouridine synthase B
PRO_0000121895

Sites

Active site391Nucleophile By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ZD46 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 66B2F753BDA8566C

FASTA17219,116
        10         20         30         40         50         60 
MGNYWLNFYK PRGISSAKLV NIVKKIIGKT KIGHAGTLDV EAEGILPLAV GEATKLIQLL 

        70         80         90        100        110        120 
IDARKTYIFS VKFGTQTDSG DYTGKVIASK DYIPSQEEVY TVCSKFIGNI RQVPPIFSAI 

       130        140        150        160        170 
KVNGVRAYKL AREGKIVELK PRNITIYDLK CLNFDKENAI ATYYTECSKG LI 

« Hide

References

[1]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ235272 Genomic DNA. Translation: CAA14953.1.
PIRG71653.
RefSeqNP_220877.1. NC_000963.1.

3D structure databases

ProteinModelPortalQ9ZD46.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272947.RP501.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAA14953; CAA14953; CAA14953.
GeneID883154.
KEGGrpr:RP501.
PATRIC17901784. VBIRicPro72556_0510.

Phylogenomic databases

eggNOGCOG0130.
KOK03177.
OMALEGHIFL.
OrthoDBEOG6358D3.

Family and domain databases

InterProIPR002501. PsdUridine_synth.
IPR020103. PsdUridine_synth_cat_dom.
IPR014780. tRNA_psdUridine_synth_TruB.
[Graphical view]
PANTHERPTHR13767. PTHR13767. 1 hit.
PfamPF01509. TruB_N. 1 hit.
[Graphical view]
SUPFAMSSF55120. SSF55120. 1 hit.
TIGRFAMsTIGR00431. TruB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTRUB_RICPR
AccessionPrimary (citable) accession number: Q9ZD46
Entry history
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names