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Q9ZD32

- FOLD_RICPR

UniProt

Q9ZD32 - FOLD_RICPR

Protein

Bifunctional protein FolD

Gene

folD

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.UniRule annotation

    Catalytic activityi

    5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH.UniRule annotation
    5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei192 – 1921NADPUniRule annotation
    Binding sitei233 – 2331NADP; via amide nitrogenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi167 – 1693NADPUniRule annotation

    GO - Molecular functioni

    1. methenyltetrahydrofolate cyclohydrolase activity Source: UniProtKB-HAMAP
    2. methylenetetrahydrofolate dehydrogenase (NADP+) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. histidine biosynthetic process Source: UniProtKB-KW
    3. methionine biosynthetic process Source: UniProtKB-KW
    4. purine nucleotide biosynthetic process Source: UniProtKB-KW
    5. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis, Methionine biosynthesis, One-carbon metabolism, Purine biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional protein FolDUniRule annotation
    Including the following 2 domains:
    Methylenetetrahydrofolate dehydrogenaseUniRule annotation (EC:1.5.1.5UniRule annotation)
    Methenyltetrahydrofolate cyclohydrolaseUniRule annotation (EC:3.5.4.9UniRule annotation)
    Gene namesi
    Name:folDUniRule annotation
    Ordered Locus Names:RP515
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 286286Bifunctional protein FolDPRO_0000199314Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi272947.RP515.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZD32.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0190.
    HOGENOMiHOG000218242.
    KOiK01491.
    OrthoDBiEOG6K6VBB.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01576. THF_DHG_CYH.
    InterProiIPR016040. NAD(P)-bd_dom.
    IPR000672. THF_DH/CycHdrlase.
    IPR020630. THF_DH/CycHdrlase_cat_dom.
    IPR020867. THF_DH/CycHdrlase_CS.
    IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
    [Graphical view]
    PfamiPF00763. THF_DHG_CYH. 1 hit.
    PF02882. THF_DHG_CYH_C. 1 hit.
    [Graphical view]
    PRINTSiPR00085. THFDHDRGNASE.
    PROSITEiPS00766. THF_DHG_CYH_1. 1 hit.
    PS00767. THF_DHG_CYH_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZD32-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVNNIIDGKA LANEILADLK LEIQGFKEKT KTSPKLAIVL VGDNPASMIY    50
    VKNKIKNAHQ VGIDTLLVNL STNIYTDDLI LKINELNLDK GISGIIVQLP 100
    LPSSIDENKI LSAVLPSKDS DGFHPLNVGY LHSGINQGFI PCTALGCLAV 150
    IKKYAPNLNG KDAVIVGRSN IVGKPLSALL LQENCSVTIC HSKTCNLSSI 200
    TSKADIVVVA IGSPLKLTAE YFNPEAIVID VGINRISHNK IAGDVDFENV 250
    KSKVKYITPV PGGIGPMTIA FLLKNTVKAF KNAIAL 286
    Length:286
    Mass (Da):30,560
    Last modified:October 11, 2004 - v2
    Checksum:i118DE987C14D857B
    GO

    Sequence cautioni

    The sequence CAA14967.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235272 Genomic DNA. Translation: CAA14967.1. Different initiation.
    PIRiE71655.
    RefSeqiNP_220891.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA14967; CAA14967; CAA14967.
    GeneIDi883180.
    KEGGirpr:RP515.
    PATRICi17901816. VBIRicPro72556_0526.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235272 Genomic DNA. Translation: CAA14967.1 . Different initiation.
    PIRi E71655.
    RefSeqi NP_220891.1. NC_000963.1.

    3D structure databases

    ProteinModelPortali Q9ZD32.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP515.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA14967 ; CAA14967 ; CAA14967 .
    GeneIDi 883180.
    KEGGi rpr:RP515.
    PATRICi 17901816. VBIRicPro72556_0526.

    Phylogenomic databases

    eggNOGi COG0190.
    HOGENOMi HOG000218242.
    KOi K01491.
    OrthoDBi EOG6K6VBB.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01576. THF_DHG_CYH.
    InterProi IPR016040. NAD(P)-bd_dom.
    IPR000672. THF_DH/CycHdrlase.
    IPR020630. THF_DH/CycHdrlase_cat_dom.
    IPR020867. THF_DH/CycHdrlase_CS.
    IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
    [Graphical view ]
    Pfami PF00763. THF_DHG_CYH. 1 hit.
    PF02882. THF_DHG_CYH_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00085. THFDHDRGNASE.
    PROSITEi PS00766. THF_DHG_CYH_1. 1 hit.
    PS00767. THF_DHG_CYH_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.

    Entry informationi

    Entry nameiFOLD_RICPR
    AccessioniPrimary (citable) accession number: Q9ZD32
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2001
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3